Results 31 to 40 of about 453,581 (148)

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

Genome Biology, 2021
Background Many neurodegenerative diseases develop only later in life, when cells in the nervous system lose their structure or function. In many forms of neurodegenerative diseases, this late-onset phenomenon remains largely unexplained.
Matan Sorek, Walaa Oweis, Malka Nissim-Rafinia, Moria Maman, Shahar Simon, Cynthia C. Hession, Xian Adiconis, Sean K. Simmons, Neville E. Sanjana, Xi Shi, Congyi Lu, Jen Q. Pan, Xiaohong Xu, Mahmoud A. Pouladi, Lisa M. Ellerby, Feng Zhang, Joshua Z. Levin, Eran Meshorer   +17 more
doaj   +1 more source

Cerebellar nuclei cells produce distinct pathogenic spike signatures in mouse models of ataxia, dystonia, and tremor

eLife
The cerebellum contributes to a diverse array of motor conditions, including ataxia, dystonia, and tremor. The neural substrates that encode this diversity are unclear.
Meike E van der Heijden, Amanda M Brown, Dominic J Kizek, Roy V Sillitoe   +3 more
doaj   +1 more source

Tyrosine Hydroxylase, Vesicular Monoamine Transporter and Dopamine Transporter mRNA Expression in Nigrostriatal Tissue of Rats with Pedunculopontine Neurotoxic Lesion

Behavioral Sciences, 2018
Background: The degeneration of the pedunculopontine nucleus (PPN) precedes the degeneration of the nigral cells in the pre-symptomatic stages of Parkinson’s disease (PD).
Lisette Blanco-Lezcano, Esteban Alberti-Amador, Mei-Li Díaz-Hung, María Elena González-Fraguela, Bárbara Estupiñán-Díaz, Teresa Serrano-Sánchez, Liliana Francis-Turner, Javier Jiménez-Martín, Yamilé Vega-Hurtado, Isabel Fernández-Jiménez   +9 more
doaj   +1 more source

Recent advances in biofabricated gut models to understand the gut-brain axis in neurological diseases

Frontiers in Medical Technology, 2022
Increasing evidence has accumulated that gut microbiome dysbiosis could be linked to neurological diseases, including both neurodegenerative and psychiatric diseases. With the high prevalence of neurological diseases, there is an urgent need to elucidate
Hohyeon Han, Jinah Jang, Jinah Jang, Jinah Jang, Jinah Jang   +4 more
doaj   +1 more source

Non-Mammalian Models for Understanding Neurological Defects in RASopathies

Biomedicines
RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders.
Mario Rodríguez-Martín, Juan Báez-Flores, Vanessa Ribes, María Isidoro-García, Jesus Lacal, Pablo Prieto-Matos   +5 more
doaj   +1 more source

Machine learning-based predictor for neurologic outcomes in patients undergoing extracorporeal cardiopulmonary resuscitation

Frontiers in Cardiovascular Medicine, 2023
BackgroundWe investigated the predictors of poor neurological outcomes in extracorporeal cardiopulmonary resuscitation (ECPR) patients using machine learning (ML) approaches.MethodsThis study was a retrospective, single-center, observational study that ...
Tae Wan Kim, Joonghyun Ahn, Jeong-Am Ryu, Jeong-Am Ryu   +3 more
doaj   +1 more source

Computational Models of Dementia and Neurological Problems [PDF]

, 2007
A critical goal of neuroscience is to fully understand neural processes and their relations to mental processes, and cognitive, affective, and behavioral disorders. Computational modeling, although still in its infancy, continues to play a central role in this endeavor. Presented here is a review of different aspects of computational modeling that help
openaire   +3 more sources

Development and optimization of human T-cell leukemia virus-specific antibody-dependent cell-mediated cytotoxicity (ADCC) assay directed to the envelope protein

Journal of Virology
An estimated 10–20 million people worldwide are infected with the deltaretrovirus human T-cell leukemia virus type 1 (HTLV-1). Although most infected individuals remain asymptomatic, some progress to develop the fatal and debilitating disease adult T ...
Cynthia A. Pise-Masison, Mohammad Arif Rahman, Daniel C. Masison, Anna Gutowska, Ramona Moles, Massimiliano Bissa, Sarkis Sarkis, Luca Schifanella, Tongqing Zhou, Jennifer Jones, Steve Jacobson, Genoveffa Franchini   +11 more
doaj   +1 more source

A neurology-inspired model of web usage

Neurocomputing, 2014
The problem of predicting human behavior has been a great challenge for several disciplines including computer science. In particular, web user browsing behavior has been studied from the machine learning point of view, a field that has been coined web usage mining (WUM). However, current WUM techniques can be negatively impacted by changes in web site
Pablo E. Román, Juan D. Velásquez
openaire   +4 more sources

Exploiting fly models to investigate rare human neurological disorders

Neural Regeneration Research
Rare neurological diseases, while individually are rare, collectively impact millions globally, leading to diverse and often severe neurological symptoms.
Tomomi Tanaka, Hyung-Lok Chung
doaj   +1 more source