Results 41 to 50 of about 777,778 (283)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device

Micromachines, 2019
The blood−brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological disorders,
Jin-Ha Choi, Mallesh Santhosh, Jeong-Woo Choi   +2 more
doaj   +1 more source

Extended Timed Up and Go assessment as a clinical indicator of cognitive state in Parkinson\u27s disease [PDF]

, 2017
Objective: To evaluate a modified extended Timed Up and Go (extended-TUG) assessment against a panel of validated clinical assessments, as an indicator of Parkinson’s disease (PD) severity and cognitive impairment. Methods: Eighty-seven participants with
Anderton, R, Byrnes, M, Evans, T, Ghosh, S, Jefferson, A, Mastaglia, F, Power, B, Walters, S   +7 more
core   +2 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice [PDF]

, 2019
Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated NADase.
DiAntonio, Aaron, Doan, Ryan A, Geisler, Stefanie, Huang, Shay X, Mao, Xianrong, Milbrandt, Jeffrey, Park, Jiwoong, Strickland, Amy, Summers, Daniel W   +8 more
core   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Modelling Neurological Diseases in Large Animals: Criteria for Model Selection and Clinical Assessment

Cells, 2022
Issue: The impact of neurological disorders is recognised globally, with one in six people affected in their lifetime and few treatments to slow or halt disease progression.
Samantha L. Eaton, Fraser Murdoch, Nina M. Rzechorzek, Gerard Thompson, Claudia Hartley, Benjamin Thomas Blacklock, Chris Proudfoot, Simon G. Lillico, Peter Tennant, Adrian Ritchie, James Nixon, Paul M. Brennan, Stefano Guido, Nadia L. Mitchell, David N. Palmer, C. Bruce A. Whitelaw, Jonathan D. Cooper, Thomas M. Wishart   +17 more
doaj   +1 more source

MRI of mouse models of neurological disorders [PDF]

NMR in Biomedicine, 2007
AbstractMRI has contributed to significant advances in the understanding of neurological diseases in humans. It has also been used to evaluate the spectrum of mouse models spanning from developmental abnormalities during embryogenesis, evaluation of transgenic and knockout models, through various neurological diseases such as stroke, tumors ...
Stasia A. Anderson, Joseph A. Frank
openaire   +3 more sources

Crying and feeding problems in infancy and cognitive outcome in preschool children born at risk : a prospective population study [PDF]

, 2009
Objective: To investigate whether regulatory problems, i.e., crying and feeding problems in infants > 3 months of age, predict cognitive outcome in preschool children born at risk even when controlled for confounding factors.
Alvarez, Anderson, Andrea Schreier, Anuntaseree, Arbuckle, Armstrong, Aylward, Bacharach, Bartram, Bauer, Baumeister, Becker, Becker, Beery, Beery, Bergman, Boekaerts, Bornstein, Brandt, Brandt, Braus, Breslau, Browne, Burgemeister, Burgemeister, Byrne, Böhm, Carvajal, Casaer, Casaer, Castellanos, Chatoor, Childers, Cohen, Dahl, DeGangi, DeGangi, Dieter Wolke, Dubowitz, Dunn, Egger, El-Faddagh, Frings, Gabriele Schmid, Gale, Golding, Gomez-Benito, Gray, Griffiths, Hair, Hanson, Hedegaard, Hiscock, Johnson, Khashan, Kiese, Kiese-Himmel, Klein, Klenberg, Kline, Laucht, Laucht, Laucht, Lepkin, Lindberg, Lindberg, Lindstam, Liu, Lou, Luiz, Lundqvist, Lundqvist-Persson, Marlow, McCall, McDermott, Minde, Mortensen, Nordberg, Northstone, Overman, Papousek, Papousek, Papousek, Peterson, Porges, Posner, Rao, Rees, Reijneveld, Reilly, Remschmidt, Renate Meyer, Richman, Riegel, Ryckman, Schermelleh-Engel, Scott, Skovgaard, St James-Roberts, St James-Roberts, St James-Roberts, St James-Roberts, Tabachnik, Thunström, Tirosh, Tong, Turkheimer, van der Wal, von Hofacker, von Hofacker, von Kries, Wake, Weinstock, West, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wolke, Wright, Wurmser, Wurmser, Wurmser   +126 more
core   +1 more source

Characterization of ribosome heterogeneity during endothelial to hematopoietic transition

FEBS Open Bio, EarlyView.
The panorama of ribosome heterogeneity during embryonic hematopoiesis has not yet been portrayed. In this study, utilizing dual‐omics data, the heterogenous dynamic of ribosome during endothelial‐to‐hematopoietic transition has been systemically described. Moreover, stage‐specific upregulation and peripheral localization of RPL27 and RACK1 in hemogenic
Xitong Tian, Di Liu, Bing Liu, Yu Lan, Jie Zhou   +4 more
wiley   +1 more source