Results 71 to 80 of about 1,748,144 (308)

Non-Mammalian Models for Understanding Neurological Defects in RASopathies

Biomedicines
RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders.
Mario Rodríguez-Martín, Juan Báez-Flores, Vanessa Ribes, María Isidoro-García, Jesus Lacal, Pablo Prieto-Matos   +5 more
doaj   +1 more source

Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats [PDF]

, 2013
We hypothesized that targeting key points in the ischemic cascade with combined neuroglobin (Ngb) overexpression and c-jun N-terminal kinase (JNK) inhibition (SP600125) would offer greater neuroprotection than single treatment after in vitro hypoxia ...
Kremer, Eric J., Macrae, I. Mhairi, McCabe, Christopher, McClure, John D., Ord, Emily N.J., Shirley, Rachel, Work, Lorraine M   +6 more
core   +2 more sources

Early Language Impairment as an Integral Part of the Cognitive Phenotype in Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Huntington's disease (HD) speech/language disorders have typically been attributed to motor and executive impairment due to striatal dysfunction. In‐depth study of linguistic skills and the role of extrastriatal structures in HD is scarce.
Arnau Puig‐Davi, Carla Franch‐Marti, Iñigo Ruiz‐Barrio, Frederic Sampedro, Jesus Perez‐Perez, Jordi A. Matias‐Guiu, Fernando Cuetos, Gonzalo Olmedo‐Saura, Laura Perez‐Carasol, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Javier Pagonabarraga, Jaime Kulisevsky, Saul Martinez‐Horta   +13 more
wiley   +1 more source

Quantitative EEG parameters can improve the predictive value of the non-traumatic neurological ICU patient prognosis through the machine learning method

Frontiers in Neurology, 2022
BackgroundBetter outcome prediction could assist in reliable classification of the illnesses in neurological intensive care unit (ICU) severity to support clinical decision-making.
Jia Tian, Yi Zhou, Hu Liu, Zhenzhen Qu, Limiao Zhang, Lidou Liu   +5 more
doaj   +1 more source

The Economic Costs of Malaria in Children in three Sub-Saharan Countries: Ghana, Tanzania and Kenya. [PDF]

, 2013
Malaria causes significant mortality and morbidity in sub-Saharan Africa (SSA), especially among children less than five years of age (U5 children).
Constenla, Dagna, Lindner, Leandro, Sauboin, Christophe, Sicuri, Elisa, Vieta, Ana   +4 more
core   +2 more sources

Computational Models of Dementia and Neurological Problems [PDF]

, 2007
A critical goal of neuroscience is to fully understand neural processes and their relations to mental processes, and cognitive, affective, and behavioral disorders. Computational modeling, although still in its infancy, continues to play a central role in this endeavor. Presented here is a review of different aspects of computational modeling that help
openaire   +3 more sources

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

NeuroLogic Decoding: (Un)supervised Neural Text Generation with Predicate Logic Constraints [PDF]

arXiv, 2020
Conditional text generation often requires lexical constraints, i.e., which words should or shouldn't be included in the output text. While the dominant recipe for conditional text generation has been large-scale pretrained language models that are finetuned on the task-specific training data, such models do not learn to follow the underlying ...
arxiv  

A neurology-inspired model of web usage

Neurocomputing, 2014
The problem of predicting human behavior has been a great challenge for several disciplines including computer science. In particular, web user browsing behavior has been studied from the machine learning point of view, a field that has been coined web usage mining (WUM). However, current WUM techniques can be negatively impacted by changes in web site
Pablo E. Román, Juan D. Velásquez
openaire   +4 more sources

Cerebello‐Prefrontal Connectivity Underlying Cognitive Dysfunction in Spinocerebellar Ataxia Type 2

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 2 (SCA2) is a hereditary cerebellar degenerative disorder, with motor and cognitive symptoms. The constellation of cognitive symptoms due to cerebellar degeneration is named cerebellar cognitive affective syndrome (CCAS), which has increasingly been recognized to profoundly impact patients' quality of life;
Ami Kumar, Ruo‐Yah Lai, Zena Fadel, Yicheng Lin, Pia Parekh, Rachel Griep, Ming‐Kai Pan, Sheng‐Han Kuo   +7 more
wiley   +1 more source