Results 91 to 100 of about 7,767,658 (304)

Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models

, 2023
Translational research is required to uncover the underlying pathomechanisms of neurological and psychiatric disorders, search for new biomarkers, and develop novel therapeutics.

core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

COVID?19 Associate Neurological Complications

, 2020
2019?novel Coronavirus disease (COVID?19) is a global health problem thataffected >2.000.000 people in the world. Although the main component ofthe disease is pulmonary disturbances, recent reports suggested neurologicalmanifestations.
Baysal-Kıraç, Leyla, Uysal, Hilmi
core   +1 more source

Eph/ephrin Function Contributes to the Patterning of Spinocerebellar Mossy Fibers Into Parasagittal Zones

Frontiers in Systems Neuroscience, 2020
Purkinje cell microcircuits perform diverse functions using widespread inputs from the brain and spinal cord. The formation of these functional circuits depends on developmental programs and molecular pathways that organize mossy fiber afferents from ...
Elizabeth P. Lackey, Elizabeth P. Lackey, Elizabeth P. Lackey, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe, Roy V. Sillitoe   +7 more
doaj   +1 more source

Standards of care for people with non-physically disabling neurological (and associated psychiatric) conditions.

, 2001
The standards of care recommended within this document are based on the collective experiences and recommendations of the Neurological Alliance of Ireland, in conjunction with members of the Elan Neurology Advisory Board (see Appendix B).
Neurological Alliance of Ireland
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Construction of neural system disease models from the perspective of cellular biomechanics and their application in teaching practice

Frontiers in Bioengineering and Biotechnology
BackgroundNeurological diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis present significant challenges to healthcare systems due to their complex pathophysiological mechanisms. Recent advancements in cellular biomechanics have opened new
Hong Xue, Qiong Zhao, Zhilan Zhao, Ruozhao Li, Guangyu Li   +4 more
doaj   +1 more source

Measuring disability in neurological rehabilitation : psychometric evaluation of two outcome measures. [PDF]

Objectives: To evaluate comprehensively the psychometric properties of the Functional Independence Measure (FIM) and the Functional Independence Measure + Functional Assessment Measure (FIM+FAM), and to compare their performance in stroke and ...
Hobart, Jeremy Charles
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Investigating the Unmet Need and Future of Neurorehabilitation in India: A Scoping Review [PDF]

Iranian Rehabilitation Journal
Objectives: This study explores the challenges of implementing physical rehabilitation for people with neurological diseases at in-hospital and community levels in India, summarizes the unmet needs of evidence-based physical neurorehabilitation in India,
Dorcas B C Gandhi, Ivy A Sebastian, Amreen Mahmood, Pradeepa Nayak, Mridul Makkar, Dimple Dawar, Nistara S Chawla, Jeyaraj Durai Pandian   +7 more
doaj