Results 91 to 100 of about 518,429 (303)

Neurological and mental health outcomes among conventional and organic farmers in Indiana, USA

, 2018
Introduction: Every farming method, whether conventional or organic, has been associated with some sort of risky behaviors leading to health issues among farmers. Substantial evidence is not available in the literature to determine whether the magnitudes
Valliant, Julia, Retushi Baidya, Farmer, James R., Ashamsa Aryal, Khalid Khan, James Farmer, Khan, Khalid M., Baidya, Retushi, Aryal, Ashamsa, Julia Valliant   +9 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Construction of neural system disease models from the perspective of cellular biomechanics and their application in teaching practice

Frontiers in Bioengineering and Biotechnology
BackgroundNeurological diseases such as Alzheimer’s, Parkinson’s, and multiple sclerosis present significant challenges to healthcare systems due to their complex pathophysiological mechanisms. Recent advancements in cellular biomechanics have opened new
Hong Xue, Qiong Zhao, Zhilan Zhao, Ruozhao Li, Guangyu Li   +4 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Investigating the Unmet Need and Future of Neurorehabilitation in India: A Scoping Review [PDF]

Iranian Rehabilitation Journal
Objectives: This study explores the challenges of implementing physical rehabilitation for people with neurological diseases at in-hospital and community levels in India, summarizes the unmet needs of evidence-based physical neurorehabilitation in India,
Dorcas B C Gandhi, Ivy A Sebastian, Amreen Mahmood, Pradeepa Nayak, Mridul Makkar, Dimple Dawar, Nistara S Chawla, Jeyaraj Durai Pandian   +7 more
doaj  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Building Models of Neurological Language

CoRR
21 pages, 6 ...
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways

Nature Communications
As human space exploration accelerates, understanding the organism-wide molecular effects of longer spaceflight in mammals becomes increasingly critical. Non-coding RNAs like miRNAs are key to regulating this landscape.
Friederike Grandke, Shusruto Rishik, Viktoria Wagner, Annika Engel, Nicole Ludwig, Kruti Calcuttawala, Fabian Kern, Verena Keller, Marcin Krawczyk, Louis Stodieck, Virginia Ferguson, Amanda Roberts, Eckart Meese, Nicholas Schaum, Steven Quake, Tony Wyss-Coray, Andreas Keller   +16 more
doaj   +1 more source