Results 21 to 30 of about 1,388,983 (287)

mRNA-1010 influenza vaccine elicits distinct and enhanced humoral immunity compared to adjuvanted inactivated vaccines

npj Vaccines
Causing approximately a billion infections globally annually, the influenza virus represents one of the globe’s greatest viral threats. While current vaccines protect against severe outcomes, especially for vulnerable populations, they offer limited ...
Paulina Kaplonek, Roger Vargas, Jessica Shih-Lu Lee, Harry Bertera, Eleanor Astley, Bethany Girard, Jaap Oostendorp, Carole Henry, Robert Paris, Wen-Han Yu, Galit Alter   +10 more
doaj   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Albert Einstein's 1916 Review Article on General Relativity [PDF]

, 2004
The first comprehensive overview of the final version of the general theory of relativity was published by Einstein in 1916 after several expositions of preliminary versions and latest revisions of the theory in November 1915.
Sauer, Tilman
core   +2 more sources

COVID‐19 Vaccination is not Associated with the Development of Idiopathic Inflammatory Myositis in U.S. Veterans

Arthritis Care &Research, Accepted Article.
Objective Several case reports have proposed a potential association between COVID‐19 vaccination and the subsequent development of idiopathic inflammatory myositis (IIM). This study examined prior COVID‐19 vaccination in US Veterans who developed new‐onset IIM compared to those without new‐onset IIM.
Caleb Hernández, Naomi Schlesinger, Jorge Rojas, Jessica A. Walsh, Tawnie J Braaten, Gary A Kunkel, Makoto Jones, Brian C Sauer, Julio Facelli, Grant W. Cannon, Dorota Lebiedz‐Odrobina   +10 more
wiley   +1 more source

Immunogenicity and safety of mRNA-based seasonal influenza vaccines encoding hemagglutinin and neuraminidase

Nature Communications
Current influenza vaccines induce immune responses to hemagglutinin (HA), a surface glycoprotein of seasonal influenza viruses, but have suboptimal effectiveness. mRNA vaccines may improve protection by targeting additional antigens such as neuraminidase
Amanda K. Rudman Spergel, Ivan T. Lee, Kindra Koslovsky, Kristi Schaefers, Andrei Avanesov, Douglas K. Logan, John Hemmersmeier, David Ensz, Daniel Stadlbauer, Bo Hu, Alicia Pucci, Jignesh Vakil, Robert Paris, Jintanat Ananworanich, Raffael Nachbagauer   +14 more
doaj   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria

Nature Communications
Messenger RNA (mRNA) therapeutics delivered via lipid nanoparticles hold the potential to treat metabolic diseases caused by protein deficiency, including propionic acidemia (PA), methylmalonic acidemia (MMA), and phenylketonuria (PKU).
Rena Baek, Kimberly Coughlan, Lei Jiang, Min Liang, Lei Ci, Harkewal Singh, Hannah Zhang, Neeraj Kaushal, Ivana Liric Rajlic, Linh Van, Rain Dimen, Alexander Cavedon, Ling Yin, Lisa Rice, Andrea Frassetto, Lin Guey, Patrick Finn, Paolo G. V. Martini   +17 more
doaj   +1 more source

Generation of a mouse model of Primary Hyperoxaluria Type 1 via CRISPR/Cas9 mediated gene editing

Journal of Biochemical and Clinical Genetics, 2019
Background: Primary Hyperoxaluria Type 1 (PH1) is an inborn error of metabolism caused by mutations in the AGXT gene, which encodes for the hepatocyte-specific enzyme alanine: glyoxylate aminotransferase (AGT).
Kimberly A Coughlan, Rajanikanth J Maganti, Andrea Frassetto, Christine M DeAntonis, meredith Wolfrom, Anne-Renee Graham, Shawn M Hillier, Steven Fortucci, Hoor Al Jandal, Sue-Jean Hong, Paloma H Giangrande, Paolo GV Martini   +11 more
doaj   +1 more source

\u3cem\u3eBataclanismo\u3c/em\u3e! Or, How Deco Bodies Transformed Postrevolutionary Mexico City [PDF]

, 2010
In the spring of 1925, Santa Anita\u27s Festival of Flowers seemed to follow its tranquil trend of previous years. The large displays of flowers, the selection of indias bonitas (as the contestants of beauty pageants organized in an attempt to stimulate ...
Ageeth, Ageeth Sluis, Araceli, Bliss, Brenner, Butler, Carmina, Carmina, Carmina, Carmina, Delpar, Doreen, Dueñas, Efraín, Elizabeth, Enstad, Eric, Fischer, Gallo, Greenhalgh, Halberstam, Hedrick, Joanne, Johns, Jonathan, Lee Peiss, Manuel Ramirez, McCleary, McClintock, Peiss, Pilcher, Robert, Rodolfo, Rubenstein, Salvador, Salvador, Salvador, Salvador, Stallybras, Travassos, Widdifield, Winokur, Zedillo Castillo, Zeitz   +43 more
core   +2 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source