Results 71 to 80 of about 1,388,983 (287)

Rising Inpatient Demands for Inherited Metabolic Disorders: Impact on Pediatric Capacity

American Journal of Medical Genetics Part A, EarlyView.
Maria Paula Silva, Kirsten Havens, Katherine Arduini, Anne Kozek, Erika Vucko, Joel Charrow, Joshua Baker, Carlos E. Prada   +7 more
wiley   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang, Robert A. Hauser, Lorraine V. Kalia, Bonnie Hersh, Zdenek Berger, Roy Llorens Arenas, Coro Paisan‐Ruiz, Kyle Fraser, Danna Jennings, Jillian H. Kluss, Sarah Huntwork‐Rodriguez, Anastasia G. Henry, J. Timothy Greenamyre   +12 more
wiley   +1 more source

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

Cell Reports, 2017
Summary: Isolated methylmalonic acidemia/aciduria (MMA) is a devastating metabolic disorder with poor outcomes despite current medical treatments. Like other mitochondrial enzymopathies, enzyme replacement therapy (ERT) is not available, and although ...
Ding An, Jessica L. Schneller, Andrea Frassetto, Shi Liang, Xuling Zhu, Ji-Sun Park, Matt Theisen, Sue-Jean Hong, Jenny Zhou, Raj Rajendran, Becca Levy, Rebecca Howell, Gilles Besin, Vladimir Presnyak, Staci Sabnis, Kerry E. Murphy-Benenato, E. Sathyajith Kumarasinghe, Timothy Salerno, Cosmin Mihai, Christine M. Lukacs, Randy J. Chandler, Lin T. Guey, Charles P. Venditti, Paolo G.V. Martini   +23 more
doaj   +1 more source

Trajetórias: a roupa moderna na cidade moderna?

dObra[s] – revista da Associação Brasileira de Estudos de Pesquisas em Moda, 2009
Este artigo, derivado da tese de doutorado intitulada Bouè Soeurs RG7091: a biografia cultural de um vestido 2, apresenta alguns modos de produção de roupas na cidade de São Paulo doinício do século XX tramada na circulação social de objetos sob a perspectiva da cultura material.
openaire   +2 more sources

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

The Burden of Respiratory Syncytial Virus (RSV) in Germany: A Comprehensive Data Analysis Suggests Underdetection of Hospitalisations and Deaths in Adults 60 Years and Older

Infectious Diseases and Therapy
Introduction In Germany, the estimation of the disease burden of respiratory syncytial virus (RSV) in older adults is limited. This makes it challenging for public health decision-makers to develop evidence-based recommendations for newly available ...
Stefan Scholz, Kristina Dobrindt, Jennifer Tufts, Sarah Adams, Parinaz Ghaswalla, Bernhard Ultsch, Jens Gottlieb   +6 more
doaj   +1 more source

Carta de la Comisión de Guerra de la Junta Superior de Cataluña al Capitán General, 1810 [PDF]

, 2005
La Comissió de Guerra informa dels problemes existents a Catalunya per a aconseguir els reemplaçaments i recomana prendre dures mesures contra la morositat als ...
Canales Gili, Esteban, Universitat Autònoma de Barcelona. Departament d'Història Moderna i Contemporània   +1 more
core  

Ethnobotanical insights into the medicinal and food uses of Lamiaceae in the Mediterranean region: A systematic review and meta‐analysis

PLANTS, PEOPLE, PLANET, EarlyView.
For generations, Mediterranean communities have used Lamiaceae or Labiatae plants like rosemary, thyme or mint to care for their health and to enrich their food. By bringing together dispersed knowledge from across the Mediterranean region, our review revealed the continuing relevance of Lamiaceae while also compiling past uses that may hold future ...
Fuencisla Cáceres, Joan Vallès, Teresa Garnatje, Airy Gras   +3 more
wiley   +1 more source

Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults

Infectious Diseases and Therapy
Introduction As no standard case definitions for respiratory syncytial virus—associated lower respiratory tract disease (RSV-LRTD) in adults are available, this study analyzed definitions for severe RSV-LRTD from previously published data in hospital and
Catherine A. Panozzo, Edward E. Walsh, Zhen Yang, Eleanor Wilson, Jaya Goswami, Sonia K. Stoszek, Adrianna Loback, Tony Ng, Beverly M. Francis, Alana K. Simorellis, Wenmei Huang, Linwei Li, Rebecca Vislay-Wade, Zhe Zheng, Evan J. Anderson, Allison August, Grace Chen, Ann R. Falsey   +17 more
doaj   +1 more source

Long-term efficacy and safety of mRNA therapy in two murine models of methylmalonic acidemiaResearch in context

EBioMedicine, 2019
Background: Isolated methylmalonic acidemia/aciduria (MMA) is an ultra-rare, serious, inherited metabolic disorder with significant morbidity and mortality.
Ding An, Andrea Frassetto, Eric Jacquinet, Marianne Eybye, Joseph Milano, Christine DeAntonis, Vi Nguyen, Rodrigo Laureano, Jaclyn Milton, Staci Sabnis, Christine M. Lukacs, Lin T. Guey   +11 more
doaj   +1 more source