Results 1 to 10 of about 7,512 (118)

Combined In Vitro and In Vivo Approaches to Propose a Putative Adverse Outcome Pathway for Acute Lung Inflammation Induced by Nanoparticles: A Study on Carbon Dots

Nanomaterials, 2021
With the growth of nanotechnologies, concerns raised regarding the potential adverse effects of nanoparticles (NPs), especially on the respiratory tract. Adverse outcome pathways (AOP) have become recently the subject of intensive studies in order to get
Maud Weiss, Jiahui Fan, Mickaël Claudel, Luc Lebeau, Françoise Pons, Carole Ronzani   +5 more
doaj   +1 more source

A Co-Culture Model of the Human Respiratory Tract to Discriminate the Toxicological Profile of Cationic Nanoparticles According to Their Surface Charge Density

Toxics, 2021
This study aimed at discriminating with sensitivity the toxicological effects of carbon dots (CDs) with various zeta potential (ζ) and charge density (Qek) in different cellular models of the human respiratory tract.
Yasmin Arezki, Juliette Cornacchia, Mickaël Rapp, Luc Lebeau, Françoise Pons, Carole Ronzani   +5 more
doaj   +1 more source

Biomass Valorization Using Natural Deep Eutectic Solvents: What’s New in France?

Molecules, 2021
With the growing interest in more environmentally friendly solvents and processes, the introduction of Natural Deep Eutectic Solvents (NaDES) as low cost, non-toxic and biodegradable solvents represent a new opportunity for green and sustainable ...
Laura Wils, Soukaina Hilali, Leslie Boudesocque-Delaye   +2 more
doaj   +1 more source

Density of surface charge is a more predictive factor of the toxicity of cationic carbon nanoparticles than zeta potential

Journal of Nanobiotechnology, 2021
Background A positive surface charge has been largely associated with nanoparticle (NP) toxicity. However, by screening a carbon NP library in macrophages, we found that a cationic charge does not systematically translate into toxicity.
Maud Weiss, Jiahui Fan, Mickaël Claudel, Thomas Sonntag, Pascal Didier, Carole Ronzani, Luc Lebeau, Françoise Pons   +7 more
doaj   +1 more source

New Application of cycloSaligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria

Molecules, 2023
In this work, we implemented for the first time the cycloSaligenyl prodrug strategy to increase the bioavailability of fosmidomycin phosphate analogs in bacteria.
Mathilde Munier, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard   +4 more
doaj   +1 more source

α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues

Molecules, 2021
Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli.
Aurore Dreneau, Fanny S. Krebs, Mathilde Munier, Chheng Ngov, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard   +7 more
doaj   +1 more source

Production of biogas and ethanol from stationery wastes using a microbial consortium isolated from soil as starter culture

Universitas Scientiarum, 2021
The conventional pretreatments used during the valorization of paper waste in renewable energies are expensive, long, slow, require high temperatures and particularly not eco-friendly.
Samir Ananou, Zineb Bougarne, Laila Manni, Naima El Ghachtouli   +3 more
doaj   +1 more source

The Multifaceted MEP Pathway: Towards New Therapeutic Perspectives

Molecules, 2023
Isoprenoids, a diverse class of natural products, are present in all living organisms. Their two universal building blocks are synthesized via two independent pathways: the mevalonate pathway and the 2-C-methyl-ᴅ-erythritol 4-phosphate (MEP) pathway. The
Alizée Allamand, Teresa Piechowiak, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard   +4 more
doaj   +1 more source

In vitro, acute and subchronic evaluation of the antidiabetic activity of Atractylis flava Desf n-butanol extract in alloxan-diabetic rats

Future Journal of Pharmaceutical Sciences, 2021
Background Diabetes mellitus is a serious complex multifactorial disorder that imposes huge health and economic burden on societies. Because the currently available medications have many drawbacks, it's important to look for alternative therapies ...
Mohamed Akram Melakhessou, Salah Eddine Marref, Naima Benkiki, Cherine Marref, Imene Becheker, Latifa Khattabi   +5 more
doaj   +1 more source

Optical control of PIEZO1 channels

Nature Communications, 2023
PIEZO proteins are large, mechanically-activated trimeric ion channels. Here the authors report a light-gated mouse PIEZO1 channel, mOP1, whereby an azobenzene-based photoswitch covalently localised at the extracellular apex of a transmembrane helix ...
Francisco Andrés Peralta, Mélaine Balcon, Adeline Martz, Deniza Biljali, Federico Cevoli, Benoit Arnould, Antoine Taly, Thierry Chataigneau, Thomas Grutter   +8 more
doaj   +1 more source