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Molecular movie of nucleotide binding to a motor protein
Biochimica Et Biophysica Acta - General Subjects, 2020The SecA DEAD (Asp-Glu-Ala-Asp) motor protein uses binding and hydrolysis of adenosine triphosphate (ATP) to push secretory proteins across the plasma membrane of bacteria. The reaction coordinate of nucleotide exchange is unclear at the atomic level of detail.We performed multiple atomistic computations of the DEAD motor domain of SecA with different ...
Ana-Nicoleta Bondar +2 more
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The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET
Journal of Molecular Biology, 2015HAMLET (human alpha-lactalbumin made lethal to tumor cells) interacts with multiple tumor cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin structure and viability. This study investigated if these diverse effects of HAMLET might be caused, in part, by a direct effect on the ATP synthase and a resulting reduction ...
James C S Ho +2 more
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Pushing, pulling and trapping - Modes of motor protein supported protein translocation [PDF]
FEBS Letters, 2007 Protein translocation across the cellular membranes is an ubiquitous and crucial activity of cells. This process is mediated by translocases that consist of a protein conducting channel and an associated motor protein.
Nico Nouwen, Arnold J M Driessen
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Molecular Assembly of Rotary and Linear Motor Proteins
Accounts of Chemical Research, 2019Molecular machines are an important and emerging frontier in research encompassing interdisciplinary subjects of chemistry, physics, biology, and nanotechnology. Although there has been major interest in creating synthetic molecular machines, research on natural molecular machines is also crucial.
Yi Jia, Junbai Li
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Regulation of molecular motor proteins
2001Motor proteins in the kinesin, dynein, and myosin superfamilies are tightly regulated to perform multiple functions in the cell requiring force generation. Although motor proteins within families are diverse in sequence and structure, there are general mechanisms by which they are regulated.
A R, Reilein +3 more
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Protein Linear Molecular Motor‐Powered Nanodevices
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
David J. G. Bakewell, Dan V. Nicolau
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Molecular circulator driven by motor proteins
Digest of Papers Microprocesses and Nanotechnology 2000. 2000 International Microprocesses and Nanotechnology Conference (IEEE Cat. No.00EX387), 2002We have fabricated a uni-directional circulator of microtubules. Since it is already technologically possible to attach foreign materials to microtubules using specific chemical or biochemical reactions, this novel technology to control the direction of microtubule movement should be applicable to drive micrometer-scaled rotating motors, or to ...
Y. Hiratsuka +4 more
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Surface Hydrophobicity Modulates the Operation of Protein Molecular Motors
2006 International Conference on Nanoscience and Nanotechnology, 2006The modulation of protein molecular motors (actin-myosin) motility has been tested on several candidate materials for microfluidics devices, all having different hydrophobicities, chemistries and nanotopographies. The analysis of the distribution of molecular properties on the molecular surface of the molecular motor protein suggests that the two very ...
Nicolau, Dan V. +4 more
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Models of protein linear molecular motors for dynamic nanodevices
Integr. Biol., 2009Protein molecular motors are natural nano-machines that convert the chemical energy from the hydrolysis of adenosine triphosphate into mechanical work. These efficient machines are central to many biological processes, including cellular motion, muscle contraction and cell division.
Fulga, Florin +2 more
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