Results 281 to 290 of about 286,246 (311)
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Molecular phylogeny of the kinesin family of microtubule motor proteins
Journal of Cell Science, 1994ABSTRACT The rapidly expanding kinesin family of microtubule motor proteins includes proteins that are involved in diverse microtubule-based functions in the cell. Phylogenetic analysis of the motor regions of the kinesin proteins reveals at least five clearly defined groups that are likely to identify kinesins with different roles in ...
H V, Goodson, S J, Kang, S A, Endow
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Chromosome distribution, molecular motors and the claret protein
Trends in Genetics, 1993Recently, proteins have been identified that are required for proper distribution of chromosomes in meiosis and mitosis. Unexpectedly, several of these are microtubule motor proteins. This finding has prompted further investigation into the basis of meiotic and mitotic chromosome movement.
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Biochemical and molecular characterization of diseases linked to motor proteins
Trends in Biochemical Sciences, 2003Recent studies have revealed that kinesin, dynein and myosin each form large superfamilies and participate in many different intracellular transport systems. Importantly, these motor proteins play significant roles in the pathogenesis of a variety of diseases.
Nobutaka, Hirokawa, Reiko, Takemura
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Protein in action: molecular motors
2005Molecular motors: energy from ATP Proteins can be grouped into a few broad categories with respect to their function. Some are regulatory, some are enzymes, some are structural, and some proteins do mechanical work. It is this latter group that we now discuss.
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Reconstitution of Motor Proteins through Molecular Assembly
Chinese Journal of Chemistry, 2019What is the most favorite and original chemistry developed in your research group?The most favorite and original chemistry developed in my research group is about the reconstitution of motor proteins in artificially designed and assembled units. It is based on the molecular assembly technique, but the method is different from the conventional approach.
Yi Jia +5 more
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Building artificial networks of protein molecular motors
SPIE Proceedings, 1997This study attempts to assess the feasibility of building purposefully designed molecular motor arrays, the proteins responsible for the movements of the living organisms and cells. The 'building' process used high-resolution e-beam patterning, originating in semiconductor technology, upgraded to make biomicrolithography compatible with the patterning ...
Dan V. Nicolau +5 more
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Protein‐protein interactions play significant roles in molecular motors
The FASEB Journal, 2022Dynein is a molecular motor for cargo transportation and force generation in cells. Dysfunction of dynein is associated with many diseases, such as ciliopathies, lissencephaly and other neurodegeneration disorders. Understanding the functions of dynein is crucial for developing new treatments of such diseases.
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AFM protein–protein interactions within the EcoR124I molecular motor
Soft Matter, 2012Dynamic Force Spectroscopy (DFS), an Atomic Force Microscopy (AFM) technique, has been used to investigate the interaction between the HsdR subunit and the core methylase (MTase) of the Type I Restriction-Modification (R-M) enzyme EcoR124I. Such systems are of interest in bionanotechnology owing to their ability to translocate DNA, thus acting as ...
Sikora, A. +3 more
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Towards the application of cytoskeletal motor proteins in molecular detection and diagnostic devices
Current Opinion in Biotechnology, 2010Over the past ten years, great advancements have been made towards using biomolecular motors for nanotechnological applications. In particular, devices using cytoskeletal motor proteins for molecular transport are maturing. First efforts towards designing such devices used motor proteins attached to micro-structured substrates for the directed ...
Korten, T., Månsson, A., Diez, S.
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Mechanical Characterization of Motor Proteins: A Molecular Dynamics Approach
Macromolecular Theory and Simulations, 2008AbstractA new approach, based on molecular dynamics, is presented to measure the mechanical properties of motor proteins, which are important for accomplishing their intracellular functions. Two different set‐ups were designed to mimic the optical tweezers and surface force apparatus experiments. The results obtained show that the stiffness and elastic
Iuliana Aprodu +2 more
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