Results 31 to 40 of about 286,246 (311)
Hydrogen sulfide intervention in focal cerebral ischemia/reperfusion injury in rats
Neural Regeneration Research, 2015 The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion.
Xin-juan Li +6 more
doaj +1 more source
Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1G93A motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice [PDF]
, 2009 Background: In humans, mutations in the enzyme glycyl-tRNA synthetase (GARS) cause motor and sensory axon loss in the peripheral nervous system, and clinical phenotypes ranging from Charcot-Marie-Tooth neuropathy to a severe infantile form of spinal ...
Hazel P Williams +35 more
core +1 more source
Differential expression of molecular motors in the motor cortex of sporadic ALS
Neurobiology of Disease, 2007 The molecular mechanisms underlying the selective neurodegeneration of motor neurons in amyotrophic lateral sclerosis (ALS) are inadequately understood.
Maria Pantelidou +5 more
doaj +1 more source
Altered SYNJ2BP-mediated mitochondrial-ER contacts in motor neuron disease
Neurobiology of Disease, 2022 Synaptojanin 2 binding protein (SYNJ2BP) is an outer mitochondrial membrane protein with a cytosolic PDZ domain that functions as a cellular signaling hub. Few studies have evaluated its role in disease.
Naemeh Pourshafie +8 more
doaj +1 more source
Tumor Formation via Loss of a Molecular Motor Protein [PDF]
Current Biology, 2006 Aneuploidy has long been suggested to be causal in tumor formation. Direct testing of this hypothesis has been difficult because of the absence of methods to specifically induce aneuploidy. The chromosome-associated kinesin motor KIF4 plays multiple roles in mitosis, and its loss leads to multiple mitotic defects including aneuploidy.
Mazumdar, Manjari +5 more
openaire +2 more sources
Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins [PDF]
, 1999 Kinesins are microtubule motors that use the energy derived from the hydrolysis of ATP to move unidirectionally along microtubules, The founding member of this still growing superfamily is conventional kinesin, a dimeric motor that moves processively ...
Woehlke, G. +5 more
core +1 more source
Sialic acid accelerates the electrophoretic velocity of injured dorsal root ganglion neurons
Neural Regeneration Research, 2015 Peripheral nerve injury has been shown to result in ectopic spontaneous discharges on soma and injured sites of sensory neurons, thereby inducing neuropathic pain.
Chen-xu Li +3 more
doaj +1 more source
Anillin propels myosin-independent constriction of actin rings
Nature Communications, 2021 Cytokinetic ring constriction during cell division requires actin but curiously is independent of myosin in many organisms. Here, the authors show that anillin, a protein enriched in the contractile ring, is a non-motor actin crosslinker that generates ...
Ondřej Kučera +8 more
doaj +1 more source
Neural Regeneration Research, 2015 The tumor suppressor p63 is one of p53 family members and plays a vital role as a regulator of neuronal apoptosis in the development of the nervous system. However, the role of p63 in mature neuronal death has not been addressed yet.
Eun Joo Bae +14 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology.
Karthikeyan Selvarasu +7 more
doaj +1 more source