Results 11 to 20 of about 286,246 (311)

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]

, 2014
Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Rosenfeld, Steven S, Gross, Steven P, Major, Jennifer, Moores, Carolyn, Jung, Y., Goulet, Adeline, Rosenfeld, Steven, Moores, Carolyn A, Major, J., Moores, Carolyn A., Jun, Yonggun, Gross, Steven, Rosenfeld, S.S., Grossmann, S.P.   +13 more
core   +1 more source

Neuroprotective effect of rapamycin on spinal cord injury via activation of the Wnt/β-catenin signaling pathway

Neural Regeneration Research, 2015
The Wnt/β-catenin signaling pathway plays a crucial role in neural development, axonal guidance, neuropathic pain remission and neuronal survival. In this study, we initially examined the effect of rapamycin on the Wnt/β-catenin signaling pathway after ...
Kai Gao, Yan-song Wang, Ya-jiang Yuan, Zhang-hui Wan, Tian-chen Yao, Hai-hong Li, Pei-fu Tang, Xi-fan Mei   +7 more
doaj   +1 more source

Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop

Neural Regeneration Research, 2015
Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown.
Ling-ling Shen, Ming-liang Jiang, Si-si Liu, Min-chun Cai, Zhong-qiu Hong, Li-qing Lin, Yan-yan Xing, Gui-lin Chen, Rui Pan, Li-juan Yang, Ying Xu, Jun Dong   +11 more
doaj   +1 more source

Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer

Acta Pharmaceutica Sinica B, 2021
Mitochondrial shape rapidly changes by dynamic balance of fusion and fission to adjust to constantly changing energy demands of cancer cells. Mitochondrial dynamics balance is exactly regulated by molecular motor consisted of myosin and actin ...
Yi Qian, Meimei Zhao, Qinghua Han, Jingkang Wang, Lixi Liao, Heng Yang, Dan Liu, Pengfei Tu, Hong Liang, Kewu Zeng   +9 more
doaj   +1 more source

Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism

Neural Regeneration Research, 2015
Microtubules have been identified as a powerful target for augmenting regeneration of injured adult axons in the central nervous system. Drugs that stabilize microtubules have shown some promise, but there are concerns that abnormally stabilizing ...
Peter W Baas, Andrew J Matamoros
doaj   +1 more source

Synthetic, Protein-Based Molecular Motors [PDF]

Biophysical Journal, 2009
We present an approach that will lead to an understanding of the operational characteristics of biological molecular motors by designing and modeling synthetic molecular motors that use a combination of natural and designed biological components. One such design is a protein-based rotationally diffusive motor dubbed the Tumbleweed (TW).
Kuwada, Nathan J., Zuckermann, Martin J., Curmi, Paul M.G., Bromley, Elizabeth H.C., Donadini, Roberta, Woolfson, Derek N., Forde, Nancy R., Linke, Heiner   +7 more
openaire   +1 more source

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development [PDF]

, 2016
This work was supported by The RJAH Institute of Orthopaedics, UK (H.F.), The SMA Trust, UK (H.F.), Cedars-Sinai Institutional startup funds (D.S), California Institute for Regenerative Medicine Grant RT-02040 (D.S.), National Center for Advancing ...
Heidi R. Fuller, Andrew R. Gross, Kaus, Anjoscha, Morris, Glen, Sareen, Dhruv, Glenn E. Morris, Fuller, H, Shirran, Sally Lorna, Catherine H. Botting, Shirran, SL, Botting, Catherine Helen, Dhruv Sareen, Mandefro, Berhan, Botting, CH, Gross, AR, Berhan Mandefro, Fuller, Heidi, Sally L. Shirran, Sareen, S, Morris, GE, Anjoscha S. Kaus, Gross, Andrew, Mandefro, B, Kaus, AS   +23 more
core   +1 more source

Stem Cell Ophthalmology Treatment Study (SCOTS) for retinal and optic nerve diseases: a preliminary report

Neural Regeneration Research, 2015
In this report, we present the results of a single patient with optic neuropathy treated within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical trial and is the largest ophthalmology stem cell
Jeffrey N Weiss, Steven Levy, Alexis Malkin   +2 more
doaj   +1 more source

Techniques for studying protein trafficking and molecular motors in neurons [PDF]

Cytoskeleton, 2016
This review focused on techniques that facilitated the visualization of protein trafficking. In the mid‐1990s the cloning of GFP allowed fluorescently tagged proteins to be expressed in cells and then visualized in real time. This advance allowed a glimpse, for the first time, of the complex system within cells for distributing proteins.
Shanxi, Feng, Don B, Arnold
openaire   +2 more sources

Electrostatically biased binding of kinesin to microtubules [PDF]

, 2011
The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the ...
Zheng Wenjun, Zheng, Wenjun, Grant, Barry J, McCammon, J. Andrew, Grant, Barry J., Cross, Robert A., Gary Huber, McCammon, J Andrew, Dlugosz, Maciej, Maria Alonso, Huber, Gary, McCammon J. Andrew, Maciej Dlugosz, Barry J. Grant, J Andrew McCammon, Robert A. Cross, Gheorghe, Dana M, Cross, R. A., M. Gheorghe Dana, Wenjun Zheng, Barry J Grant, Alonso, M. (Maria), Alonso Maria, Robert A Cross, J. Andrew McCammon, Dana M Gheorghe, Dana M. Gheorghe, Cross Robert A., Alonso, Maria, Grant Barry J., Huber Gary, Cross, Robert A, Gheorghe, Dana M., Dlugosz Maciej   +33 more
core   +1 more source