Results 1 to 10 of about 286,246 (311)
Chromatin maintenance by a molecular motor protein. [PDF]
Nucleus, 2011 The kinesin motor protein KIF4 performs essential functions in mitosis. Like other mitotic kinesins, loss of KIF4 causes spindle defects, aneuploidy, genomic instability and ultimately tumor formation. However, KIF4 is unique among molecular motors in that it resides in the cell nucleus throughout interphase, suggesting a non-mitotic function as well ...
Mazumdar M, Sung MH, Misteli T.
europepmc +4 more sources
Molecular switch-like regulation in motor proteins [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018 Motor proteins are powered by nucleotide hydrolysis and exert mechanical work to carry out many fundamental biological tasks. To ensure their correct and efficient performance, the motors' activities are allosterically regulated by additional factors that enhance or suppress their NTPase activity.
Sara Tafoya, CARLOS Bustamante
exaly +5 more sources
Engineered Pendrin Protein, an Anion Transporter and Molecular Motor [PDF]
Journal of Biological Chemistry, 2011 Pendrin and prestin both belong to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Pendrin (SLC26A4) is a chloride-iodide transporter that is found at the luminal membrane of follicular cells in the thyroid gland as well as in the endolymphatic duct and sac of the inner ear, whereas prestin (SLC26A5) is expressed in ...
Xiaodong Tan +2 more
exaly +3 more sources
Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation. [PDF]
Cell Rep, 2021 Swarnkar S +12 more
europepmc +2 more sources
Selective cell-surface labeling of the molecular motor protein prestin [PDF]
Biochemical and Biophysical Research Communications, 2011 Prestin, a multipass transmembrane protein whose N- and C-termini are localized to the cytoplasm, must be trafficked to the plasma membrane to fulfill its cellular function as a molecular motor. One challenge in studying prestin sequence-function relationships within living cells is separating the effects of amino acid substitutions on prestin ...
Jonathan J Silberg +2 more
exaly +3 more sources
Molecular Motor Proteins and Amyotrophic Lateral Sclerosis [PDF]
International Journal of Molecular Sciences, 2011 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons in the brain, brainstem and spinal cord, which is characterized by motor dysfunction, muscle dystrophy and progressive paralysis. Both inherited and sporadic forms of ALS share common pathological features, however, the initial trigger of neurodegeneration ...
Soo, Kai Y, Farg, Manal, Atkin, Julie D.
openaire +2 more sources
Acrylamide neurotoxicity on the cerebrum of weaning rats
Neural Regeneration Research, 2015 The mechanism underlying acrylamide-induced neurotoxicity remains controversial. Previous studies have focused on acrylamide-induced toxicity in adult rodents, but neurotoxicity in weaning rats has not been investigated.
Su-min Tian +5 more
doaj +1 more source
Construction of a Chassis for a Tripartite Protein-Based Molecular Motor [PDF]
ACS Synthetic Biology, 2017 Improving our understanding of biological motors, both to fully comprehend their activities in vital processes, and to exploit their impressive abilities for use in bionanotechnology, is highly desirable. One means of understanding these systems is through the production of synthetic molecular motors.
Lara S. R. Small +9 more
openaire +6 more sources
Neural Regeneration Research, 2015 Ferumoxytol, an iron replacement product, is a new type of superparamagnetic iron oxide approved by the US Food and Drug Administration. Herein, we assessed the feasibility of tracking transplanted human adipose-derived stem cells labeled with ...
Yan Yin +5 more
doaj +1 more source
A Metal Switch for Controlling the Activity of Molecular Motor Proteins [PDF]
Biophysical Journal, 2011 Kinesins are molecular motors that require a divalent metal ion (for example, Mg(2+)) to convert the energy of ATP hydrolysis into directed force production along microtubules. Here we present the crystal structure of a recombinant kinesin motor domain bound to Mn(2+) and ADP and report on a serine-to-cysteine substitution in the switch 1 motif of ...
Cochran, Jared C. +3 more
openaire +3 more sources