Results 71 to 80 of about 286,246 (311)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A novel isoform of MAP4 organises the paraxial microtubule array required for muscle cell differentiation

eLife, 2015
The microtubule cytoskeleton is critical for muscle cell differentiation and undergoes reorganisation into an array of paraxial microtubules, which serves as template for contractile sarcomere formation.
Binyam Mogessie, Daniel Roth, Zainab Rahil, Anne Straube   +3 more
doaj   +1 more source

Protein allostery. computational characterization of diguanylate cyclase PleD [PDF]

, 2009
In biology, accurate cellular regulation in response to environmental signals is crucial for the fitness of organisms. On the molecular level the modulation of protein activity is often achieved by the binding of a signaling molecule or by covalent ...
Schmid, Franziska F.-F.
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Molecular Motor, KIF13A, Controls Anxiety by Transporting the Serotonin Type 1A Receptor

Cell Reports, 2013
Molecular motors are fundamental to neuronal morphogenesis and function. However, the extent to which molecular motors are involved in higher brain functions remains largely unknown.
Ruyun Zhou, Shinsuke Niwa, Laurent Guillaud, Ying Tong, Nobutaka Hirokawa   +4 more
doaj   +1 more source

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome

Frontiers in Neuroscience, 2021
KIF1A is a microtubule-dependent motor protein responsible for fast anterograde transport of synaptic vesicle precursors in neurons. Pathogenic variants in KIF1A have been associated with a wide spectrum of neurological disorders.
Cinthia Aguilera, Stefan Hümmer, Stefan Hümmer, Marc Masanas, Elisabeth Gabau, Miriam Guitart, A. Arockia Jeyaprakash, Miguel F. Segura, Anna Santamaria, Anna Ruiz   +9 more
doaj   +1 more source

The agrin gene codes for a family of basal lamina proteins that differ in function and distribution [PDF]

, 1992
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction.
Tsim, K. W., McMahan, U. J., Escher, G., Gensch, Erin M., Tsim, Karl W.K., Escher, Gérard, Kroger, S., Kröger, Stephan, Horton, Sharon E., Ruegg, M. A., Tsim, Karl W. K., Horton, S. E., Gensch, E. M., Ruegg, Markus A.   +13 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Physical pictures of rotation mechanisms of F1- and V1-ATPases: Leading roles of translational, configurational entropy of water

Frontiers in Molecular Biosciences, 2023
We aim to develop a theory based on a concept other than the chemo-mechanical coupling (transduction of chemical free energy of ATP to mechanical work) for an ATP-driven protein complex. Experimental results conflicting with the chemo-mechanical coupling
Satoshi Yasuda, Satoshi Yasuda, Satoshi Yasuda, Tomohiko Hayashi, Tomohiko Hayashi, Takeshi Murata, Takeshi Murata, Takeshi Murata, Masahiro Kinoshita, Masahiro Kinoshita, Masahiro Kinoshita   +10 more
doaj   +1 more source

Molecular Highways—Navigating Collisions of DNA Motor Proteins

Journal of Molecular Biology, 2018
Fundamental biological processes require concurrent sharing of DNA by numerous motor proteins and complexes. Thus, collision, congestion, and roadblocks are inescapable on these busy "molecular highways." The consequences of these traffic problems are diverse, resulting in complex cellular mechanisms to resolve threats to genome stability and ensure ...
Tung T, Le, Michelle D, Wang
openaire   +3 more sources