Results 121 to 130 of about 5,860,920 (296)

Assembly of Protein Molecular Motors for Nano-Bio-Machines

Seibutsu Butsuri, 2005
Protein nanomachines have many attractive features. Whether we can take advantage of those depends on future technical advancements to reconstitute their functions in vitro in a useful manner. Breakthroughs towards this direction have been made in the field of protein molecular motors.
HIRATSUKA, Yuichi, UYEDA, Taro Q. P.
openaire   +2 more sources

Molecular Mechanisms and Potential Biomarkers of Neuropsychiatric Disorders in Parkinson’s Disease

Journal of Integrative Neuroscience
Parkinson’s disease (PD) is the second most common degenerative disease of the central nervous system, characterized by both motor and non-motor disorders. Non-motor disorders include dementia, depression, and anxiety.
Wojciech Owecki, Anna Futyma, Olga Kokorniak, Aleksandra Szczech, Bartosz Słowikowski, Joanna Poszwa, Oliwia Szymanowicz, Ulyana Goutor, Paweł P. Jagodziński, Wojciech Kozubski, Jolanta Dorszewska   +10 more
doaj   +1 more source

History of the Ohio Bureau of Motor Vehicles

, 2001
Title from caption (viewed Mar.
Ohio. Bureau of Motor Vehicles.
core  

A programmable optical angle clamp for rotary molecular motors [PDF]

, 2007
Optical tweezers are widely used for experimental investigation of linear molecular motors. The rates and force dependence of steps in the mechanochemical cycle of linear motors have been probed giving detailed insight into motor mechanisms. With similar
Futai, Masamitsu, Bai, Fan, Bilyard, Thomas, Hosokawa, Hiroyuki, Pilizota, Teuta, Berry, Richard M., Berry, Richard Michael   +6 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

All Proteins Have a Basic Molecular Formula

, 2011
This study proposes a basic molecular formula for all proteins. A total of 10,739 proteins belonging to 9 different protein groups classified on the basis of their functions were selected randomly.
Homa Torabizadeh
core   +1 more source