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Reconstitution of Motor Proteins through Molecular Assembly
Chinese Journal of Chemistry, 2019What is the most favorite and original chemistry developed in your research group?The most favorite and original chemistry developed in my research group is about the reconstitution of motor proteins in artificially designed and assembled units. It is based on the molecular assembly technique, but the method is different from the conventional approach.
Yi Jia +5 more
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Surface Hydrophobicity Modulates the Operation of Protein Molecular Motors
2006 International Conference on Nanoscience and Nanotechnology, 2006The modulation of protein molecular motors (actin-myosin) motility has been tested on several candidate materials for microfluidics devices, all having different hydrophobicities, chemistries and nanotopographies. The analysis of the distribution of molecular properties on the molecular surface of the molecular motor protein suggests that the two very ...
Nicolau, Dan V. +4 more
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Proteināprotein interactions play significant roles in molecular motors
The FASEB Journal, 2022Dynein is a molecular motor for cargo transportation and force generation in cells. Dysfunction of dynein is associated with many diseases, such as ciliopathies, lissencephaly and other neurodegeneration disorders. Understanding the functions of dynein is crucial for developing new treatments of such diseases.
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Chromosome distribution, molecular motors and the claret protein
Trends in Genetics, 1993Recently, proteins have been identified that are required for proper distribution of chromosomes in meiosis and mitosis. Unexpectedly, several of these are microtubule motor proteins. This finding has prompted further investigation into the basis of meiotic and mitotic chromosome movement.
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Models of protein linear molecular motors for dynamic nanodevices
Integr. Biol., 2009Protein molecular motors are natural nano-machines that convert the chemical energy from the hydrolysis of adenosine triphosphate into mechanical work. These efficient machines are central to many biological processes, including cellular motion, muscle contraction and cell division.
Fulga, Florin +2 more
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AFM proteināprotein interactions within the EcoR124I molecular motor
Soft Matter, 2012Dynamic Force Spectroscopy (DFS), an Atomic Force Microscopy (AFM) technique, has been used to investigate the interaction between the HsdR subunit and the core methylase (MTase) of the Type I Restriction-Modification (R-M) enzyme EcoR124I. Such systems are of interest in bionanotechnology owing to their ability to translocate DNA, thus acting as ...
Sikora, A. +3 more
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Protein in action: molecular motors
2005Molecular motors: energy from ATP Proteins can be grouped into a few broad categories with respect to their function. Some are regulatory, some are enzymes, some are structural, and some proteins do mechanical work. It is this latter group that we now discuss.
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Motor protein motion along microtubules for molecular detection
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, 2011A molecular detection system was realized using the change in the characteristics of the kinesin-coated bead motion along protein-attached microtubules. A hybrid bio/microfluidics device with a microtubule immobilized main channel and protein-injected sub-channels allowed us to compare different protein attachments and several control experiments with ...
M.C. Tarhan +4 more
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Molecular phylogeny of the kinesin family of microtubule motor proteins
Journal of Cell Science, 1994ABSTRACT The rapidly expanding kinesin family of microtubule motor proteins includes proteins that are involved in diverse microtubule-based functions in the cell. Phylogenetic analysis of the motor regions of the kinesin proteins reveals at least five clearly defined groups that are likely to identify kinesins with different roles in ...
H V, Goodson, S J, Kang, S A, Endow
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Biochemical and molecular characterization of diseases linked to motor proteins
Trends in Biochemical Sciences, 2003Recent studies have revealed that kinesin, dynein and myosin each form large superfamilies and participate in many different intracellular transport systems. Importantly, these motor proteins play significant roles in the pathogenesis of a variety of diseases.
Nobutaka, Hirokawa, Reiko, Takemura
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