Results 81 to 90 of about 395,686 (301)

An archaellum filament composed of two alternating subunits

Nature Communications, 2022
The archaellum is a molecular machine used by archaea to swim, consisting of an intracellular motor that drives the rotation of an extracellular filament composed of multiple copies of proteins named archaellins.
Lavinia Gambelli, Michail N. Isupov, Rebecca Conners, Mathew McLaren, Annett Bellack, Vicki Gold, Reinhard Rachel, Bertram Daum   +7 more
doaj   +1 more source

Is the Cell Really a Machine? [PDF]

, 2019
It has become customary to conceptualize the living cell as an intricate piece of machinery, different to a man-made machine only in terms of its superior complexity.
Nicholson, Daniel J.
core  

Enhanced reaction kinetics in biological cells

, 2008
The cell cytoskeleton is a striking example of "active" medium driven out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to have a spectacular impact on the mechanical and rheological properties of the cellular medium, as well as
A Ajdari, B Alberts, C Storm, C. Loverdo, D Holcman, D Mizuno, F Nedelec, FJ Nedelec, G Kolesov, H Salman, I Eliazar, J Howard, K Kruse, L Le Goff, M Coppey, M Slutsky, M. Moreau, MA Lomholt, MF Shlesinger, MF Shlesinger, MP Sheetz, O Berg, O Bénichou, O Bénichou, O Bénichou, O Thoumine, O. Bénichou, P Dalhaimer, R Voituriez, R Voituriez, R. Voituriez, S Condamin, S Huet, S Redner   +33 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Nonlinearity of Mechanochemical Motions in Motor Proteins [PDF]

, 2010
The assumption of linear response of protein molecules to thermal noise or structural perturbations, such as ligand binding or detachment, is broadly used in the studies of protein dynamics.
A Cressman, A Kitao, Alexander S. Mikhailov, AN Zaikin, AR Atilgan, AT Winfree, B Brooks, B Brooks, BJ Foth, C Chennubhotla, F Piazza, F Tama, F Tama, I Bahar, J-L Liao, JR Sellers, K Hayashi, K Hinsen, L Yang, LD Landau, M Gerstein, M Ikeguchi, M Iwaki, M Kikkawa, M Kikkawa, M Levitt, M Tomishige, MM Tirion, N Gō, N Hirokawa, N Koga, O Miyashita, P Doruker, PD Coureux, PD Coureux, R Nitta, T Haliloglu, Toshio Yanagida, W Zheng, Willy Wriggers, Y Togashi, Yuichi Togashi   +41 more
core   +7 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Reconstitution of dynein transport to the microtubule plus end by kinesin

eLife, 2014
Cytoplasmic dynein powers intracellular movement of cargo toward the microtubule minus end. The first step in a variety of dynein transport events is the targeting of dynein to the dynamic microtubule plus end, but the molecular mechanism underlying this
Anthony J Roberts, Brian S Goodman, Samara L Reck-Peterson   +2 more
doaj   +1 more source

Non-ciliary Roles of IFT Proteins in Cell Division and Polycystic Kidney Diseases

Frontiers in Cell and Developmental Biology, 2020
Cilia are small organelles present at the surface of most differentiated cells where they act as sensors for mechanical or biochemical stimuli. Cilia assembly and function require the Intraflagellar Transport (IFT) machinery, an intracellular transport ...
Benjamin Vitre, Audrey Guesdon, Benedicte Delaval   +2 more
doaj   +1 more source

Snf2 family ATPases and DExx box helicases:differences and unifying concepts from high-resolution crystal structures [PDF]

, 2006
Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA–protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases,
Aasland, Ahne, Akhtar, Andrew Flaus, Asturias, Auble, Auble, Auble, Bazett-Jones, Becker, Beerens, Bouazoune, Boyer, Boyer, Briggs, Caruthers, Corona, Cote, Dasgupta, Davis, Deaconescu, Dhalluin, Dumont, Durr, Eisen, Fan, Fitzgerald, Flaus, Flaus, Goldmark, Gorbalenya, Grune, Harald Dürr, Havas, Hishida, Ito, Jaskelioff, Kagalwala, Karl-Peter Hopfner, Kawaoka, Kim, Laurent, Laurent, Levin, Levin, Lia, Mahdi, Mannhaupt, Mizuguchi, Morillon, Myong, Peterson, Petukhova, Petukhova, Phelan, Pray-Grant, Quinn, Richmond, Ristic, Saha, Saha, Schild, Sengoku, Serebrov, Shen, Shinohara, Simic, Sims, Singleton, Singleton, Singleton, Smith, Soultanas, Sprouse, Stanley, Studitsky, Subramanya, Sukhodolets, Svejstrup, Swagemakers, Tai, Thoma, Tom Owen-Hughes, Tran, Tsukiyama, van den Boom, van Gool, Van Komen, Velankar, Wang, Whitehouse, Woudstra, Yu, Yu, Zhang, Zofall   +95 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source