Results 61 to 70 of about 98,232 (273)

A Simple Experimental Model to Investigate Force Range for Membrane Nanotube Formation

Frontiers in Materials, 2016
The presence of membrane tubules in living cells is essential to many biological processes. In cells, one mechanism to form nano-sized lipid tubules is via molecular motor induced bilayer extraction. In this paper, we describe a simple experimental model
Chai eLor, Joseph D Lopes, Michelle K Mattson-Hoss, Jing eXu, Linda S Hirst   +4 more
doaj   +1 more source

Entropy and efficiency of a molecular motor model

, 2009
In this paper we investigate the use of path-integral formalism and the concepts of entropy and traffic in the context of molecular motors. We show that together with time-reversal symmetry breaking arguments one can find bounds on efficiencies of such ...
Bram Wynants, Eliran Boksenbojm, Kipnis C, Maes C, Parrondo J M R, Schmiedl T, Wang H   +6 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

An experimental study of the putative mechanism of a synthetic autonomous rotary DNA nanomotor [PDF]

Royal Society Open Science, 2017
DNA has been used to construct a wide variety of nanoscale molecular devices. Inspiration for such synthetic molecular machines is frequently drawn from protein motors, which are naturally occurring and ubiquitous.
K. E. Dunn, M. C. Leake, A. J. M. Wollman, M. A. Trefzer, S. Johnson, A. M. Tyrrell   +5 more
doaj   +1 more source

Stochastic thermodynamics of active Brownian particles

, 2013
Examples of self propulsion in strongly fluctuating environment is abound in nature, e.g., molecular motors and pumps operating in living cells. Starting from Langevin equation of motion, we develop a fluctuating thermodynamic description of self ...
Chaudhuri, Debasish, Ganguly, Chandrima
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Development and optimization of an injectable in-situ gel system for sustained release of anti-tuberculosis drugs

Scientific Reports
Addressing the challenges of drug-resistant Mycobacterium tuberculosis requires regular drug intake and consistent therapeutic drug concentrations, for which in-situ gel systems offer a promising solution by enabling sustained drug release.
Pooraniammal Balu, Srimari Srikanth, Divya Prakash Gnandhas, Ramya Devi Durai, Venkasubramanian Ulaganathan, Vedha Hari B Narayanan   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Delayed Chromosome Alignment to the Spindle Equator Increases the Rate of Chromosome Missegregation in Cancer Cell Lines

Biomolecules, 2018
For appropriate chromosome segregation, kinetochores on sister chromatids have to attach to microtubules from opposite spindle poles (bi-orientation).
Kinue Kuniyasu, Kenji Iemura, Kozo Tanaka   +2 more
doaj   +1 more source

Fluctuation effects in bidirectional cargo transport

, 2014
We discuss a theoretical model for bidirectional cargo transport in biological cells, which is driven by teams of molecular motors and subject to thermal fluctuations.
Appert-Rolland, Cécile, Klein, Sarah, Santen, Ludger   +2 more
core   +2 more sources