Results 1 to 10 of about 9,020,555 (147)

Impact of Monacolin K‐Containing Supplements on Lipid Profile: A Meta‐Analysis of Randomised Controlled Trials [PDF]

Endocrinology, Diabetes & Metabolism
Background Natural products have gained attention as alternative strategies for managing dyslipidemia, particularly in individuals who are resistant or unwilling to use conventional pharmacotherapies. Monacolin K, a compound derived from natural sources,
Tannaz Jamialahmadi, Elaheh Mirhadi, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +4 more
doaj   +3 more sources

Metabolomic insights into <i>Monascus</i>-fermented rice products: Implications for monacolin K content and nutritional optimization. [PDF]

Food Sci Nutr
Monascus‐fermented rice products (MFRPs) are widely used in traditional and modern medicinal practices for their health benefits and monacolin K content, which is a natural statin that can lower cholesterol levels. However, the comprehensive metabolic impact of varying monacolin K levels and sterilization methods on MFRPs has not been fully elucidated.
Zhao Y, Luo M, Jiang Q, Ma Y, Liu X, Bai X, Zhou L, Xie J.   +7 more
europepmc   +3 more sources

De Novo RNA Sequencing and Transcriptome Analysis of Monascus purpureus and Analysis of Key Genes Involved in Monacolin K Biosynthesis. [PDF]

PLoS ONE, 2017
Monascus purpureus is an important medicinal and edible microbial resource. To facilitate biological, biochemical, and molecular research on medicinal components of M. purpureus, we investigated the M. purpureus transcriptome by RNA sequencing (RNA-seq).
Chan Zhang, Jian Liang, Le Yang, Baoguo Sun, Chengtao Wang   +4 more
doaj   +3 more sources

The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy [PDF]

Biomolecules, 2022
Several studies suggest that different combinations of nutraceutical supplements may improve the lipid profile, representing a viable alternative to statins. However, their effects on individuals with myopathy need to be investigated.
Ines Villano, Marco La Marra, Salvatore Allocca, Ciro Rosario Ilardi, Rita Polito, Chiara Porro, Sergio Chieffi, Giovanni Messina, Vincenzo Monda, Girolamo Di Maio, Antonietta Messina   +10 more
doaj   +4 more sources

Improvement of Monacolin K and Pigment Production in Monascus by 5-Azacytidine [PDF]

Journal of Fungi
Monascus species are known to produce various secondary metabolites with polyketide structures, including Monacolins, pigments, and citrinin. This study investigates the effects of 5-azacytidine on Monascus M1 and RP2.
Chan Zhang, Haijiao Wang, Qing Sun, Arzugul Ablimit, Huijun Dong, Congcong Wang, Duchen Zhai, Bobo Zhang, Wenlin Hu, Chengjian Liu, Chengtao Wang   +10 more
doaj   +3 more sources

Identification of the high-yield monacolin K strain from Monascus spp. and its submerged fermentation using different medicinal plants [PDF]

Botanical Studies, 2022
Background Medical plants confer various benefits to human health and their bioconversion through microbial fermentation can increase efficacy, reduce toxicity, conserve resources and produce new chemical components.
Yu-Pei Chen, Hong-Tan Wu, Ing-Er Hwang, Fang-Fang Chen, Jeng-Yuan Yao, Yiling Yin, Meng-Yun Chen, Li-Ling Liaw, Yang-Cheng Kuo   +8 more
doaj   +2 more sources

Metabolomics Analysis of the Effect of Glutamic Acid on Monacolin K Synthesis in Monascus purpureus [PDF]

Frontiers in Microbiology, 2020
Monacolin K is a secondary metabolite produced by Monascus with beneficial effects on health, including the ability to lower cholesterol. We previously showed that the yield of monacolin K was significantly improved when glutamic acid was added to the ...
Chan Zhang, Chan Zhang, Nan Zhang, Mengxue Chen, Haijiao Wang, Jiachen Shi, Bei Wang, Bei Wang, Baoguo Sun, Baoguo Sun, Chengtao Wang, Chengtao Wang   +11 more
doaj   +2 more sources

Enhanced Monacolin K Production in Monascus purpureus Via Mutagenesis and Nitrogen Source Optimization. [PDF]

J Basic Microbiol
ABSTRACT Monascus fungi are valued for their production of Monacolin K (MK), a bioactive compound with recognized lipid‐lowering and multifunctional properties. To enhance MK yield in solid‐state fermentation, this study combined atmospheric and room‐temperature plasma (ARTP) mutagenesis with L‐arginine supplementation.
Yang C, Yajing Y, Housheng H.
europepmc   +2 more sources

A systematic study of the production of Monacolin K by solid state fermentation of Monascus ruber [PDF]

AMB Express, 2022
Key points A systematic study for Monacolin K produced by SSF of Monascus ruber. Initial moisture and bran content are the key factors for the SSF of Monascus. A proper bran content could suppress the influence of excessive media amount.
Xiuhe Liu, Aonan Sun, Qing Li, Yamin Du, Tao Zhao   +4 more
doaj   +2 more sources

Determination of Monacolin K and Citrinin in the Presence of Other Active Ingredients Found in Selected Food Supplements by HPLC-DAD [PDF]

Molecules
A universal HPLC method with diode array detection was developed for the separation and determination of the lactone and acid forms of monacolin K in the presence of other active ingredients (vitamins B1, B6, B12, and folic acid) found in selected ...
Urszula Hubicka, Barbara Żuromska-Witek, Marek Szlósarczyk, Ewelina Sołtys, Martyna Rusak, Izabela Gacal   +5 more
doaj   +2 more sources