Results 11 to 20 of about 3,104 (182)

Improvement of Monacolin K and Pigment Production in Monascus by 5-Azacytidine [PDF]

Journal of Fungi
Monascus species are known to produce various secondary metabolites with polyketide structures, including Monacolins, pigments, and citrinin. This study investigates the effects of 5-azacytidine on Monascus M1 and RP2.
Chan Zhang, Haijiao Wang, Qing Sun, Arzugul Ablimit, Huijun Dong, Congcong Wang, Duchen Zhai, Bobo Zhang, Wenlin Hu, Chengjian Liu, Chengtao Wang   +10 more
doaj   +5 more sources

Effects of Monacolin K in Nondiabetic Patients with NAFLD: A Pilot Study. [PDF]

Nutrients, 2023
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver condition with significant risk of progression to steatohepatitis and cirrhosis. Therapeutic strategies in NAFLD include lifestyle changes mainly related to dietary interventions and use of drugs or nutritional components that could improve plasma lipid profiles and insulin sensitivity
Da Porto A, Donnini D, Vanin F, Romanin A, Antonello M, Toritto P, Varisco E, Brosolo G, Catena C, Sechi LA, Soardo G.   +10 more
europepmc   +7 more sources

Monacolin K as a Natural Alternative for Synthetic Statins

Quality in Sport
Introduction: This review paper aims to verify the safety of monacolin K, examine the effect on blood cholesterol levels, discuss the contribution to the reduction of cardiovascular risk and indicate examples of pleiotropic effects of this substance.
Julia Kozakiewicz, Aleksandra Okońska, Michał Ziemba, Kamil Kościelecki, Agnieszka Kalisz, Magdalena Krakowiak, Aleksandra Kaczmarek   +6 more
doaj   +5 more sources

Glutamic acid promotes monacolin K production and monacolin K biosynthetic gene cluster expression in Monascus. [PDF]

AMB Express, 2017
This study investigated the effects of glutamic acid on production of monacolin K and expression of the monacolin K biosynthetic gene cluster. When Monascus M1 was grown in glutamic medium instead of in the original medium, monacolin K production increased from 48.4 to 215.4 mg l-1, monacolin K production increased by 3.5 times.
Zhang C, Liang J, Yang L, Chai S, Zhang C, Sun B, Wang C.   +6 more
europepmc   +5 more sources

Metabolomics Analysis of the Effect of Glutamic Acid on Monacolin K Synthesis in Monascus purpureus [PDF]

Frontiers in Microbiology, 2020
Monacolin K is a secondary metabolite produced by Monascus with beneficial effects on health, including the ability to lower cholesterol. We previously showed that the yield of monacolin K was significantly improved when glutamic acid was added to the ...
Chan Zhang, Chan Zhang, Nan Zhang, Mengxue Chen, Haijiao Wang, Jiachen Shi, Bei Wang, Bei Wang, Baoguo Sun, Baoguo Sun, Chengtao Wang, Chengtao Wang   +11 more
doaj   +5 more sources

Metabolomic insights into Monascus-fermented rice products: Implications for monacolin K content and nutritional optimization. [PDF]

Food Sci Nutr
Monascus‐fermented rice products (MFRPs) are widely used in traditional and modern medicinal practices for their health benefits and monacolin K content, which is a natural statin that can lower cholesterol levels. However, the comprehensive metabolic impact of varying monacolin K levels and sterilization methods on MFRPs has not been fully elucidated.
Zhao Y, Luo M, Jiang Q, Ma Y, Liu X, Bai X, Zhou L, Xie J.   +7 more
europepmc   +3 more sources

The Role of Nutraceutical Supplements, Monacolin K and Astaxanthin, and Diet in Blood Cholesterol Homeostasis in Patients with Myopathy [PDF]

Biomolecules, 2022
Several studies suggest that different combinations of nutraceutical supplements may improve the lipid profile, representing a viable alternative to statins. However, their effects on individuals with myopathy need to be investigated.
Ines Villano, Marco La Marra, Salvatore Allocca, Ciro Rosario Ilardi, Rita Polito, Chiara Porro, Sergio Chieffi, Giovanni Messina, Vincenzo Monda, Girolamo Di Maio, Antonietta Messina   +10 more
doaj   +4 more sources

De Novo RNA Sequencing and Transcriptome Analysis of Monascus purpureus and Analysis of Key Genes Involved in Monacolin K Biosynthesis. [PDF]

PLoS ONE, 2017
Monascus purpureus is an important medicinal and edible microbial resource. To facilitate biological, biochemical, and molecular research on medicinal components of M. purpureus, we investigated the M. purpureus transcriptome by RNA sequencing (RNA-seq).
Chan Zhang, Jian Liang, Le Yang, Baoguo Sun, Chengtao Wang   +4 more
doaj   +3 more sources

Monacolin K in the treatment of hypercholesterolemia - chance or threat?

Journal of Education, Health and Sport
Introduction Hypercholesterolemia is a primary element leading to the occurrence of cardiovascular diseases, which are the most common cause of death worldwide. One of the most effective drugs used in the treatment of hypercholesterolemia are statins.
Katarzyna Krotowska
doaj   +4 more sources

A systematic study of the production of Monacolin K by solid state fermentation of Monascus ruber [PDF]

AMB Express, 2022
Key points A systematic study for Monacolin K produced by SSF of Monascus ruber. Initial moisture and bran content are the key factors for the SSF of Monascus. A proper bran content could suppress the influence of excessive media amount.
Xiuhe Liu, Aonan Sun, Qing Li, Yamin Du, Tao Zhao   +4 more
doaj   +5 more sources