Results 31 to 40 of about 9,020,555 (147)

Microbial synthetic biology for plant metabolite production: a strategy to reconcile human health with the realization of the UN Sustainable Development Goals

Biofuels, Bioproducts and Biorefining, Volume 17, Issue 6, Page 1485-1495, November/December 2023., 2023
Abstract Plants produce a wide range of secondary metabolites that provide an array of benefits for human health. Challenges of native host production systems such as excessive land use, large carbon footprints, long production times, and high production costs often make plant‐based production of these critical metabolites inefficient and unsustainable.
Fernando Perez Rojo, Paton Vuong, J. Jane Pillow, Parwinder Kaur   +3 more
wiley   +1 more source

Role of lipoprotein(a) in atherosclerotic cardiovascular disease: A review of current and emerging therapies

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 43, Issue 10, Page 1051-1063, October 2023., 2023
AbstractLipoprotein(a), or Lp(a), is structurally like low‐density lipoprotein (LDL) but differs in that it contains glycoprotein apolipoprotein(a) [apo(a)]. Due to its prothrombotic and proinflammatory properties, Lp(a) is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic valve stenosis.
Ibrahim S. Alhomoud, Azita Talasaz, Anurag Mehta, Michael S. Kelly, Evan M. Sisson, John D. Bucheit, Roy Brown, Dave L. Dixon   +7 more
wiley   +1 more source

Additional file 1 of A systematic study of the production of Monacolin K by solid state fermentation of Monascus ruber

, 2022
Additional file 1. Figure S1 HPLC chromatogram chart of Monacolin K; Figure S2 The standard curve of Monacolin K and Table S1 Recoveries obtained from the analysis of red yeast rice samples spiked with Monacolin K; Table S2 Plackett-Burman experiment ...
Xiuhe Liu (12193790), Yamin Du (6185714), Tao Zhao (12193796), Aonan Sun (12193793), Qing Li (84975)   +4 more
core   +1 more source

Comparative study of red yeast rice with high monacolin K, low citrinin concentration and pigments in white rice and brown rice

Czech Journal of Food Sciences, 2019
Growth pigments and metabolites of monacolin K and citrinin were compared for Monascus purpureus during 14-day solid-state ermentation on white rice and brown rice (Chai-Nart cultivar).
Pramuan Saithong, Wanida Tewaruth Chitisankul, Supachai Nitipan   +2 more
doaj   +1 more source

Monacolin K as a Natural Alternative for Synthetic Statins [PDF]

Introduction: This review paper aims to verify the safety of monacolin K, examine the effect on blood cholesterol levels, discuss the contribution to the reduction of cardiovascular risk and indicate examples of pleiotropic effects of this substance ...
Julia Kozakiewicz, Magdalena Krakowiak, Aleksandra Okońska, Kamil Kościelecki, Aleksandra Kaczmarek, Michał Ziemba, Agnieszka Kalisz   +6 more
core   +3 more sources

Inoculums Preparation and Detoxification Process in Monascus Fermented Rice Production

Journal of Tropical Life Science, 2016
Monascus fermented rice (MFR), or angkak are well known for their ability to produce monacolin K, a statin compound that potential as a cholesterol-lowering agent.
Marlia Singgih Wibowo, Nur Azizah Fitria, Sri Priatni   +2 more
doaj   +1 more source

Optimization of solid-state fermentation technology of functional Monascus [PDF]

Zhongguo niangzao
To increase the yield of acidic Monacolin K in functional Monascus, the solid-state fermentation technology was optimized. Using Monascus purpureus as the fermentation strain to perform solid-state fermentation and acid Monacolin K yield as the ...
SUN Qiuwan, HONG Housheng
doaj   +1 more source

The Influence of Temperature and Ethanol Concentration in Monacolin K Extraction from Monascus Fermented Rice [PDF]

, 2014
One of the major causes of death is coronary heart disease which is usually caused by hypercholesterolemia. HMG-CoA reductase is a rate-limiting enzyme that plays important role in cholesterol biosynthetis. The enzyme acts a prime target for pharmacology
Ratnaningrum, Diah, Damayanti, Sophi, Priatni, Sri, Saraswaty, Vienna, Singgih, Marlia   +4 more
core   +1 more source

The current trend and challenges of developing red yeast rice-based food supplements for hypercholesterolemia

Journal of Future Foods, 2023
Hypercholesterolemia is a risk factor of cardiovascular diseases, which have been managed using statin drugs. Red yeast rice (RYR) as a traditional food in the Eastern Asia countries has anti-hyperlipidemia activity.
Gong Chen, Wanbo Chen, Jinhong Xu, Guodong Ma, Xinge Hu, Guoxun Chen   +5 more
doaj   +1 more source

Proteomics-based study on the mechanism of Monacolin K biosynthesis in Monascus purpureus

Food Science and Human Wellness
This study investigated the regulatory roles of the mokC, mokD, and LaeA genes in Monacolin K production by Monascus purpureus. Overexpression strains C8 (mokC), D8 (mokD), and L3 (LaeA) were compared with the wild-type M1 strain.
Chan Zhang, Huijun Dong, Arzugul Ablimit, Qing Sun, Haijiao Wang, Congcong Wang, Ang Huang, Bobo Zhang, Wenlin Hu, Chengjian Liu, Chengtao Wang   +10 more
doaj   +1 more source