Red yeast rice with monacolin K for the improvement of hyperlipidemia: A narrative review. [PDF]
World J Clin CasesLow-density lipoprotein cholesterol (LDL-C) is the most causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Red yeast rice (RYR) is a nutraceutical widely used as a lipid-lowering dietary supplement. The main cholesterol-lower agents in RYR are monacolins, particularly monacolin K, a weak reversible inhibitor of 3-hydroxy-3-methyl ...
English K.
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Optimization of fermentation conditions for acidic Monacolin K production by Monascus purpureus with response surface method [PDF]
Zhongguo niangzaoAcidic Monacolin K is a physiologically active substance with multiple functions such as lipid-lowering, anti-fatigue, anti-microbial, anti-tumor and neuroprotective, and is considered to be a good hypolipidemic drug.
CHEN Yang, HONG Housheng
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The Role of Enoyl Reductase in the Monacolin K Biosynthesis Pathway in <i>Monascus</i> spp. [PDF]
J Fungi (Basel)Monacolin K (MK), a secondary metabolite produced by Monascus spp. with the ability to inhibit cholesterol production, is structurally identical to lovastatin produced by Aspergillus terreus. In the lovastatin biosynthetic pathway, the polyketide synthase (PKS) encoded by lovB must work together with the enoyl reductase encoded by lovC to ensure ...
Yao T, Wang X, Chen F.
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Does EFSA statement on Monacolin content of nutraceutical combinations impair their lipid lowering effect? The LopiGLIK experience [PDF]
Clinical Diabetes and EndocrinologyBackground Monacolin-K, the active component of red yeast rice (RYR), reduces cholesterol by inhibiting HMG-CoA reductase. Following safety concerns, the European Food Safety Authority (EFSA) recommended limiting Monacolin-K intake to less than 3 mg/day ...
Alessia Izzo +3 more
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An overview on the therapeutic potential and anticancer mechanism of Monacolin K / Lovastatin
Pharmacological Research - Modern Chinese Medicine, 2022 Rising pollution levels, altered lifestyles, and poor diets are contributing to a dramatic increase in the prevalence of cancer worldwide. When it comes to threats to human health, cancer is among the top concerns.
Monu Monu +5 more
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Biological Research, 2011 In China, Monascus spp., a traditional fungus used in fermentation, is used as a natural food additive. Monascus spp. can produce a secondary metabolite, monacolin K namely, which is proven to be a cholesterol-lowering and hypotensive agent.
Jia-Long Sun +3 more
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Scientific Opinion on additional scientific data related to the safety of monacolins from red yeast rice submitted pursuant to Article 8(4) of Regulation (EC) No 1925/2006. [PDF]
EFSA JAbstract The Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the safety of monacolins from red yeast rice (RYR), which have been placed under Union scrutiny in Part C of Annex III in accordance with Article 8(4) of Regulation (EC) No 1925/2006.
EFSA Panel on Nutrition +17 more
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Advances in the synthesis and relationship with fermentation of Monacolin K genes in Hongqu [PDF]
Zhongguo niangzaoHongqu, as a fermented product with lipid-lowering effect, is produced by fermentation with Monascus and rice. Monacolin K, the most representative lipid-lowering component in Hongqu, is synthesized through the synergy of 9 genes (mokA to mokI), with the
CHEN Ruonan, FENG Rui, ZHOU Heng, HU Qing, JI Shen, WANG Shaomin
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Effect of Monacolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome. [PDF]
Biomed Pharmacother, 2018 Metabolic syndrome (MetS) is a world-wide epidemic disease with an increased risk of morbidity and mortality. Treatment strategies of MetS include pharmacologic and non-pharmacologic interventions and in this respect a relevant role has been shown for nutraceutical compounds (NCs). The aim of this study was to investigate the efficacy and safety of NCs
Mazza A +8 more
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A Monascus pilosus MS-1 strain with high-yield monacolin K but no citrinin. [PDF]
Food Sci Biotechnol, 2016 Monacolin K (MK) produced by Monascus spp. is mostly used to regulate cholesterol level, while it can be contaminated by citrinin, a mycotoxin yielded by some Monascus strains. To develop production of citrinin-free MK, an M. sp. MS-1 strain, identified as M.
Feng Y, Chen W, Chen F.
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