Results 81 to 90 of about 1,041,172 (171)

Identification of neutralizing antibodies against monkeypox virus using high-throughput sequencing of A35+H3L+B cells from patients with convalescent monkeypox

Virus Research
The global monkeypox virus (MPXV) outbreak in 2022 emphasizes the urgent need for effective and accessible new-generation vaccines and neutralizing antibodies. Herein, we identified MPXV-neutralizing antibodies using high-throughput single-cell RNA and V(
Ruitian Hou, Qiwei Jiang, Meiling Cheng, Jun Dai, Huiqin Yang, Jiao Yuan, Xiao Li, Xiaoping Tang, Haisheng Yu   +8 more
doaj   +1 more source

Identification of Repurposed Drugs Against Monkeypox Virus Through Comprehensive Virtual Screening

Biotechnology Journal, Volume 21, Issue 8, August 2026.
Graphical Abstract and Lay Summary By combining interspecies protein analysis with advanced virtual screening, this study identifies potent repurposed drug candidates—including vindesine and LY2090314—targeting mpox DNA topoisomerase and polymerase. This workflow provides a rapid, practical framework for antiviral discovery against emerging infectious ...
Taeho Yu, Woo Dae Jang, Sang Yup Lee
wiley   +1 more source

Monkeypox: Uma zoonose de preocupação mundial

Pubvet, 2022
A monkeypox é uma doença zoonótica de origem africana, causada pelo vírus monkeypox (MPXV), pertencente à família Poxviridae. Inicialmente descoberto na década de 1958, o surto registrado em 2022 compreende a doença em sua maior distribuição mundial ...
Ana Carolina Leal da Cruz Lisboa, Bruna Crescenti Tukasan, Caio Ferreira Repik, Raul José Silva Girio   +3 more
doaj   +1 more source

Strategy of developing nucleic acid-based universal monkeypox vaccine candidates

Frontiers in Immunology, 2022
Until May 2022, zoonotic infectious disease monkeypox (MPX) caused by the monkeypox virus (MPXV) was one of the forgotten viruses considered to be geographically limited in African countries even though few cases outside of Africa were identified ...
Dimitri Papukashvili, Nino Rcheulishvili, Cong Liu, Xingyun Wang, Yunjiao He, Peng George Wang   +5 more
doaj   +1 more source

CD4 Count and Clinical Outcomes of Mpox in People Living With HIV: A Systematic Review and Meta‐Analysis

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background HIV causes immunosuppression by targeting CD4+ T lymphocytes, which may influence susceptibility and clinical outcomes of coinfections such as the Mpox virus (MPXV). Despite conflicting evidence, understanding the relationship between CD4 counts and MPXV severity in people living with HIV (PLWH) remains critical.
Kesaobaka Batisani, David Chisompola, Tolulope Joseph Ogunniyi, Godsave Binlak Wazhi, Ronald Simusokwe, Misheck Chileshe, Dike Ujunwa Precious, Mahlale Maenetja, Rosemary Mosweu, Hezron Lubemba, Stephen Ebuka Ukaobasi, Nandi Mwangilwa, Lungowe Mulope, Roseline Dzekem Dine, Charles Saleji, Eustarckio Kazonga, Omolola Onifade, Abdulmajeed Opeyemi Agboola, Panji Kwanga, Chipo Zidana, Martin Chakulya, Sepiso Kenias Masenga   +21 more
wiley   +1 more source

Discovery and Structural Characterization of a Highly Protective Neutralizing Antibody Targeting the Mpox Virus A35R Protein

MedComm, Volume 7, Issue 7, July 2026.
High‐affinity monoclonal antibodies (mAbs) targeting the MPXV EEV protein A35R were rapidly isolated using mRNA‐LNP vaccination and the Beacon single‐cell sorting Optofluidic platform, followed by functional profiling. One mAb, 17H1, potently neutralized authentic MPXV and conferred complete protection in vivo.
Shimeng Bai, Shuo Song, Xin Wang, Yuxin Xiao, Yun Long, Fenfang Wu, Fuxiang Wang, Zhongyi Fan, Jianqing Xu, Maozhou He, Hongzhou Lu   +10 more
wiley   +1 more source

Nano‐Silver‐Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

Exploration, Volume 6, Issue 3, June 2026.
There is no effective method to treat this virus and prevent its transmission. To address this, we have developed a nano‐silver‐selenium liquid dressing (AgSe@LD) by combining silver and selenium nanoparticles with commercial liquid dressings. This unique AgSe@LD formulation exhibits good adhesion, stability and toughness and demonstrates efficient ...
Wei Wang, Mengjun Li, Zining Liu, Jiayin Chen, Ke Liu, Fengfang Wei, Junrui Li, Yixuan Xie, Yushan Jiang, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Minghui Yang, Hua Ma, Ruilin Zhang, Chenguang Shen, Yuhui Liao   +15 more
wiley   +1 more source

Severe Scrotal Cellulitis in a Young Man

JEADV Clinical Practice, EarlyView.
Hamad El Hajj, Vera Al Baaklini, Dima Jeha, Alfred Ammoury   +3 more
wiley   +1 more source

Human judgment forecasts of human monkeypox transmission and burden in non-endemic countries

, 2022
Background: An increase in reported human infections by the monkeypox virus (MPXV) has been observed in multiple non-endemic countries. Forecasts of transmission and disease burden associated with MPXV can support public health decision making.
Gaia Dempsey, Andrew A. Lover, Tamay Besiroglu, Nikos I. Bosse, David Braun, Maimuna S. Majumder, Sylvain Chevalier, Juan Cambeiro, Sam Abbott, Allison Codi, Thomas McAndrew, Srini Venkatramanan, Paolo Bocchini   +12 more
core   +1 more source

In Silico Design and Computational Characterization of Novel Chimeric Multiepitope Antigens for Mpox Serosurveillance: An Immunoinformatics Approach

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims The Monkeypox (Mpox) virus is a zoonotic Orthopoxvirus with a global outbreak that began in 2022, with more than 132,000 confirmed cases and 1500 deaths across over 128 countries. The pandemic preparedness pipeline emphasizes the importance of diagnostic surveillance of pathogens in at‐risk populations to monitor ...
Roland Ngwese Akwelle, Robert Adamu Shey, Mary Teke Efeti, Lekeayi Nelson Acha, Gordon Takop Nchanji, Yanick Aqua Stong Tangan, Joan Amban Chick, Ntang Emmaculate Yaah, Lahngong Methodius Shinyuy, Cabirou Mounchili Shintouo, Bernis Neneyoh Yengo, Abey Blessings Ayuk, Junior Ekunidi Engarimbi, Ketura Yaje Gwei, Brinate Teke Tebo, Derrick Neba Nebangwa, Beltine Muyer Tamnjong, Luc Vanhamme, Jacob Souopgui, Vincent P. K. Titanji, Stephen Mbigha Ghogomu   +20 more
wiley   +1 more source