Progress of non‐motor symptoms in early‐onset Parkinson's disease
Ibrain, EarlyView.This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang +5 more
wiley +1 more source
Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
Ibrain, EarlyView.Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra +4 more
wiley +1 more source
MAO-A and the EEG Recognition Memory Signal in Left Parietal Cortex [PDF]
, 2014 A key part of episodic memory, or memory for the events of our lives, is recognition memory. Recognition memory is the ability to remember previously encountered stimuli.
Curran, Tim +3 more
core +1 more source
Ambience-associated variation in serum biomarkers of oxidative stress in donkeys of arid tracts in India [PDF]
, 2013 An investigation was carried out in donkeys to discover serum biomarkers of oxidative stress during moderate and extremely hot conditions. Serum biomarkers included vitamin A, vitamin C, vitamin E, glutathione, catalase, superoxide dismutase, monoamine ...
Kataria, AK, Kataria, N
core +2 more sources
8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects [PDF]
, 2020 Parkinson’s disease is a common neurodegenerative disorder. In this study, the monoamine oxidase inhibitory activity and potential anti-parkinsonian effects of 8-propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one (FCS303), a new synthetic coumarin, were ...
López, Jose Luis +3 more
core +1 more source
Therapeutic targeting of chromatin alterations in leukemia and solid tumors
International Journal of Cancer, EarlyView.Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner +7 more
wiley +1 more source
Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [11C]-harmine positron emission tomography study [PDF]
, 2012 Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions.
Boskovic, Rada +9 more
core +2 more sources
Hearing Loss and Its Relation to Loneliness and Depression—A Population‐Based Cohort Study
The Laryngoscope, EarlyView.This study investigated the relationship between hearing loss, loneliness, and depression using data from the Gutenberg Health Study. It found that hearing loss is significantly associated with higher levels of loneliness and depressive symptoms, with severe to complete hearing loss markedly increasing risks for loneliness and mild to severe hearing ...
Julia Döge +15 more
wiley +1 more source
Novel perspectives in redox biology and pathophysiology of failing myocytes: modulation of the intramyocardial redox milieu for therapeutic interventions - A review article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology [PDF]
, 2016 The prevalence of heart failure (HF) is still increasing worldwide, with enormous human, social, and economic costs, in spite of huge efforts in understanding pathogeneticmechanisms and in developing effective therapies that have transformed this ...
Angelini, Annalisa +8 more
core +5 more sources
Bidirectional Associations Between Tinnitus Subtypes and Psychiatric Conditions
The Laryngoscope, EarlyView.ABSTRACT Objective To evaluate the temporal and bidirectional relationships between tinnitus subtypes—pulsatile tinnitus (PT) and non‐pulsatile tinnitus (NPT)—and psychiatric conditions, specifically generalized anxiety disorder (GAD) and major depression (MD).
Daniel Karasik +4 more
wiley +1 more source