Results 211 to 220 of about 101,843 (265)
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Monoclonal Antibodies to Benzodiazepines
Journal of Neurochemistry, 1985Abstract: Four hybridoma lines secreting monoclonal antibodies to benzodiazepines were produced after BALB/c mice were immunized with a benzodiazepine‐bovine serum albumin conjugate. The monoclonal antibodies were purified from ascites fluids, and their binding affinities for benzodiazepines and other benzodiazepine receptor ligands were determined ...
A L, De Blas +5 more
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Purification of Monoclonal Antibodies
Current Protocols in Molecular Biology, 1997AbstractThe uses of monoclonal antibodies as enzyme conjugates and as immunoaffinity reagents require their purification from the crude ascites fluid. This unit provides protocols for purification using protein A‐Sepharose chromatography and affinity chromatography, which are superior to ammonium sulfate precipitation, gel filtration, or ion‐exchange ...
Steven A. Fuller +2 more
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Antibodies and Selection of Monoclonal Antibodies
2015Monoclonal antibodies are universal binding molecules with a high specificity for their target and are indispensable tools in research, diagnostics and therapy. The biotechnological generation of monoclonal antibodies was enabled by the hybridoma technology published in 1975 by Köhler and Milstein.
Katrin Messerschmidt +2 more
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Revue Francaise de Transfusion et Immuno-hématologie, 1988
The Rh antibodies were studied by manual serological techniques (see Daniels' report on Kell related antigens), using human red cells of common and rare Rh phenotypes in an attempt to identify their specificity and/or usefulness as reagents. The report is divided into 3 sections : section I anti-D antibodies, section II other Rh specifities, section ...
C Lomas, P Tippett
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The Rh antibodies were studied by manual serological techniques (see Daniels' report on Kell related antigens), using human red cells of common and rare Rh phenotypes in an attempt to identify their specificity and/or usefulness as reagents. The report is divided into 3 sections : section I anti-D antibodies, section II other Rh specifities, section ...
C Lomas, P Tippett
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Current Opinion in Cardiology, 1996
Monoclonal antibody technology has become an important diagnostic and therapeutic tool in many areas of medicine, including the prevention and treatment of organ transplant rejection. The monoclonal antibody that has been most widely used clinically is OKT3, a murine monoclonal antibody directed against the CD3 receptor on the surface of human T cells.
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Monoclonal antibody technology has become an important diagnostic and therapeutic tool in many areas of medicine, including the prevention and treatment of organ transplant rejection. The monoclonal antibody that has been most widely used clinically is OKT3, a murine monoclonal antibody directed against the CD3 receptor on the surface of human T cells.
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2009
The ability to produce and exploit monoclonal antibodies (mAbs) has revolutionized many areas of biological sciences. The unique property of an mAb is that it is a single species of immunoglobulin (IG) molecule. This means that the specificity of the interaction of the paratopes on the IG, with the epitopes on an antigenic target, is the same on every ...
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The ability to produce and exploit monoclonal antibodies (mAbs) has revolutionized many areas of biological sciences. The unique property of an mAb is that it is a single species of immunoglobulin (IG) molecule. This means that the specificity of the interaction of the paratopes on the IG, with the epitopes on an antigenic target, is the same on every ...
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Monoclonal antibodies and arthritis
Agents and Actions, 1990Monoclonal antibodies to certain cell surface constituents on lymphocytes, monocytes and macrophages have been administered to Lewis rats with developing, established or adoptively transferred arthritis, to determine any immunomodulatory properties.
Stephen L. Carney +2 more
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2001
Publisher Summary Monoclonal antibody therapy (MAT) makes use of all the major features of the immune response. It involves vaccination/ immunization, albeit in experimental animals, to induce the desired specific immune response. It exploits the high specificity, selectivity, and affinity of the antibody complementarity-determining regions (CDRs ...
Josef S. Smolen, John Park
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Publisher Summary Monoclonal antibody therapy (MAT) makes use of all the major features of the immune response. It involves vaccination/ immunization, albeit in experimental animals, to induce the desired specific immune response. It exploits the high specificity, selectivity, and affinity of the antibody complementarity-determining regions (CDRs ...
Josef S. Smolen, John Park
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Monoclonal Antibodies: A Review
Current Clinical Pharmacology, 2018Over the last three decades, monoclonal antibodies (MAbs) have made a striking transformation from scientific tools to powerful human therapeutics. Muromonab CD3 a murine MAb was the first FDA approved therapeutic MAb for the prevention of kidney transplant rejection.
Preeti Sidhu +6 more
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Frontiers in Bioscience, 2006
The concept of targeted therapy was conceived through increased understanding of the biological pathways involved in the pathogenesis of cancer and subsequently identification of the most appropriate antigens to target. Monoclonal antibody therapy harnesses host defense mechanisms through activation of the antibody dependent cytotoxic pathway and ...
Michael R Bishop, Deirdre O'Mahony
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The concept of targeted therapy was conceived through increased understanding of the biological pathways involved in the pathogenesis of cancer and subsequently identification of the most appropriate antigens to target. Monoclonal antibody therapy harnesses host defense mechanisms through activation of the antibody dependent cytotoxic pathway and ...
Michael R Bishop, Deirdre O'Mahony
openaire +3 more sources