Results 21 to 30 of about 2,198,135 (358)

Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63

Journal of Skin Cancer, 2013
Mouse models have informed us that p63 is critical for normal epidermal development and homeostasis. The p53/p63/p73 family is expressed as multiple protein isoforms due to a combination of alternative promoter usage and C-terminal alternative splicing ...
Kathryn E. King, Linan Ha, Tura Camilli, Wendy C. Weinberg   +3 more
doaj   +1 more source

Hybridoma technology; advancements, clinical significance, and future aspects

Journal of Genetic Engineering and Biotechnology, 2021
Background Hybridoma technology is one of the most common methods used to produce monoclonal antibodies. In this process, antibody-producing B lymphocytes are isolated from mice after immunizing the mice with specific antigen and are fused with immortal ...
Sanchita Mitra, Pushpa Chaudhary Tomar
doaj   +1 more source

ON THE NOTION OF SYNERGY OF MONOCLONAL ANTIBODIES AS DRUGS [PDF]

Biotechnologia Acta, 2013
History of developing synergy between monoclonal antibodies, anti-tumor activity of monoclonal antibodies against tyrosine-kinases receptors EGFR/ErbB-1 and HER2/ErbB-2 as well as growth factor VEGF in various combinations are considered in the article ...
Michael Sela
doaj   +1 more source

CH2 Domain of Mouse IgG3 Governs Antibody Oligomerization, Increases Functional Affinity to Multivalent Antigens and Enhances Hemagglutination

Frontiers in Immunology, 2018
Mouse IgG3 is highly protective against several life-threatening bacteria. This isotype is the only one among mouse IgGs that forms non-covalent oligomers, has increased functional affinity to polyvalent antigens, and efficiently agglutinates ...
Tomasz Klaus, Tomasz Klaus, Joanna Bereta   +2 more
doaj   +1 more source

Establishment of a pseudovirus neutralization assay based on SARS-CoV-2 S protein incorporated into lentiviral particles

Biosafety and Health, 2022
The coronavirus disease 2019 (COVID-19) is still causing a wide range of infections and deaths due to the high variability of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Sheng Wang, Lizhen Liu, Can Wang, Ziqiang Wang, Xuhua Duan, Gang Chen, Hu Zhou, Hong Shao   +7 more
doaj  

Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategy

Journal of Biomedical Science, 2022
Background Calls for the coronavirus to be treated as an endemic illness, such as the flu, are increasing. After achieving high coverage of COVID-19 vaccination, therapeutic drugs have become important for future SARS-CoV-2 variant outbreaks.
Chen-Yi Chiang, Mei-Yu Chen, Chia-Wei Hsu, Chia-Yeh Liu, Yu-Wen Tsai, Hung-Chun Liao, Jia-Ying Yan, Zih-Shiuan Chuang, Hsin-I. Wang, Chien-Hsiung Pan, Chia-Yi Yu, Guann-Yi Yu, Ching-Len Liao, Shih-Jen Liu, Hsin-Wei Chen   +14 more
doaj   +1 more source

European headache federation guideline on the use of monoclonal antibodies acting on the calcitonin gene related peptide or its receptor for migraine prevention

The Journal of Headache and Pain, 2019
Background and aimMonoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor ...
S. Sacco, L. Bendtsen, M. Ashina, U. Reuter, G. Terwindt, D. Mitsikostas, P. Martelletti   +6 more
semanticscholar   +1 more source

The Use of Biotechnological Drugs in Pediatrics on the Example of Monoclonal Antibodies: Clinical Pharmacology View

Педиатрическая фармакология, 2021
The article reviews monoclonal antibodies, its structure, classifications, pharmacodynamics, pharmacokinetics, and adverse effects. There are examples for each section.
Alexey S. Kolbin, Liudmila I. Yemelyanova   +1 more
doaj   +1 more source

The pharmacology and therapeutic applications of monoclonal antibodies

Pharmacology Research & Perspectives, 2019
Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the market. To date, approximately 80 mAbs have been granted marketing approval.
María Sofía Castelli, P. Mcgonigle, P. Hornby   +2 more
semanticscholar   +1 more source

Characterization of protective and non-protective surface membrane carbohydrate epitopes of Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 1987
We have produced a number of monoclonal antibodies, protective and non-protective, which recognize a complex of schistosomula antigens, including the 38 kDa antigen. Eight different protective and non-protective monoclonal antibodies, varying in isotypes,
Albert I. Ko, Donald A. Harn
doaj   +1 more source