Results 1 to 10 of about 771,983 (316)

A new dawn for monoclonal antibodies against antimicrobial resistant bacteria

Frontiers in Microbiology, 2022
Antimicrobial resistance (AMR) is a quickly advancing threat for human health worldwide and almost 5 million deaths are already attributable to this phenomenon every year.
Marco Troisi, Eleonora Marini, Valentina Abbiento, Samuele Stazzoni, Emanuele Andreano, Rino Rappuoli, Rino Rappuoli   +6 more
doaj   +1 more source

GPI-Anchored Fibromodulin as a Novel Target in Chronic Lymphocytic Leukemia: Diagnostic and Therapeutic Implications [PDF]

Iranian Journal of Immunology, 2019
Background: We have previously reported the aberrant expression of Fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL). Although FMOD has been considered as a cytoplasmic or secretory protein, we discovered the cell surface expression
Lia Farahi, Fatemeh Ghaemimanesh, Saeideh Milani, Seyed Mohsen Razavi, Reza Hadavi, Ali Ahmad Bayat, Ali Salimi, Mohammad Mehdi Akhondi, Hodjattallah Rabbani   +8 more
doaj   +1 more source

High-throughput bactericidal assays for monoclonal antibody screening against antimicrobial resistant Neisseria gonorrhoeae

Frontiers in Microbiology, 2023
Neisseria gonorrhoeae (gonococcus) is an obligate human pathogen and the etiological agent of the sexually transmitted disease gonorrhea. The rapid rise in gonococcal resistance to all currently available antimicrobials has become a significant public ...
Samuele Stazzoni, Marco Troisi, Valentina Abbiento, Valentina Abbiento, Claudia Sala, Emanuele Andreano, Rino Rappuoli, Rino Rappuoli   +7 more
doaj   +1 more source

Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees

Nature Communications, 2022
Here, Andreano and Paciello et al. show, at single cell level, the functional and genetic characteristics underlying the Omicron BA.1 and BA.2 cross-protective antibody response in naïve and previously infected COVID-19 vaccinees.
Emanuele Andreano, Ida Paciello, Silvia Marchese, Lorena Donnici, Giulio Pierleoni, Giulia Piccini, Noemi Manganaro, Elisa Pantano, Valentina Abbiento, Piero Pileri, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Piet Maes, Concetta De Santi, Claudia Sala, Emanuele Montomoli, Raffaele De Francesco, Rino Rappuoli   +18 more
doaj   +1 more source

Multiple Tolerization Subtractive Immunization (MTSI) Protocol: Effects on Mice and Monoclonal Antibody Specificity

Frontiers in Immunology, 2021
Monoclonal antibodies (mAbs) have been a valuable tool to elucidate several biological processes, such as stem cell differentiation and cancer, and contributed to virtually all areas of biomedical sciences.
Marina de Lima Fontes, Franciny Mara de Lima Neves, Kelvin Sousa Santos, Ana Marisa Fusco-Almeida, Maria José Soares Mendes Giannini, Sergio Luis Felisbino, Elenice Deffune, Andrei Moroz   +7 more
doaj   +1 more source

Recent Progress in the Discovery and Development of Monoclonal Antibodies against Viral Infections

Biomedicines, 2022
Monoclonal antibodies (mAbs), the new revolutionary class of medications, are fast becoming tools against various diseases thanks to a unique structure and function that allow them to bind highly specific targets or receptors.
Pardis Mokhtary, Zeinab Pourhashem, Akram Abouei Mehrizi, Claudia Sala, Rino Rappuoli   +4 more
doaj   +1 more source

Human monoclonal antibodies and monoclonal antibody multispecificity [PDF]

British Journal of Cancer, 1987
The majority of human anti-tumour monoclonal antibodies (Mabs) isolated to date have been disappointing. Firstly, they react or cross react with intracellular cytoskeletal proteins or nuclear antigens and therefore are of limited value as blood borne agents.
AM Campbell, P Whitford, RE Leake
openaire   +2 more sources

mRNA vaccines and hybrid immunity use different B cell germlines against Omicron BA.4 and BA.5

Nature Communications, 2023
Omicron strains of SARS-CoV-2 have displayed high transmissibility and immunological escape to antibody responses derived from natural infection and vaccination.
Emanuele Andreano, Ida Paciello, Giulio Pierleoni, Giuseppe Maccari, Giada Antonelli, Valentina Abbiento, Piero Pileri, Linda Benincasa, Ginevra Giglioli, Giulia Piccini, Concetta De Santi, Claudia Sala, Duccio Medini, Emanuele Montomoli, Piet Maes, Rino Rappuoli   +15 more
doaj   +1 more source

Development of a triple antibody sandwich enzyme-linked immunosorbent assay for cassava mosaic disease detection using a monoclonal antibody to Sri Lankan cassava mosaic virus

Virology Journal, 2021
Background Cassava mosaic disease (CMD) is one of the most devastating viral diseases for cassava production in Africa and Asia. Accurate yet affordable diagnostics are one of the fundamental tools supporting successful CMD management, especially in ...
Saengsoon Charoenvilaisiri, Channarong Seepiban, Mallika Kumpoosiri, Sombat Rukpratanporn, Nuchnard Warin, Bencharong Phuangrat, Phakamat Chitchuea, Sirima Siripaitoon, Orawan Chatchawankanphanich, Oraprapai Gajanandana   +9 more
doaj   +1 more source

Monoclonal Antibodies for Bacterial Pathogens: Mechanisms of Action and Engineering Approaches for Enhanced Effector Functions

Biomedicines, 2022
Monoclonal antibody (mAb) therapy has opened a new era in the pharmaceutical field, finding application in various areas of research, from cancer to infectious diseases.
Fabiola Vacca, Claudia Sala, Rino Rappuoli   +2 more
doaj   +1 more source