Results 141 to 150 of about 317,992 (233)

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Detection of Monocyte Subsets in the Bone Marrow of Patients With Acute Myeloid Leukemia and Its Clinical Significance. [PDF]

J Immunol Res
Zhang L, Chen M, Zhong H, Huang J, Xu Z, Yin M, Li Y, Cao C.   +7 more
europepmc   +1 more source

Macrophage and monocyte subsets as new therapeutic targets in cancer immunotherapy. [PDF]

ESMO Open, 2023
Fendl B, Berghoff AS, Preusser M, Maier B.   +3 more
europepmc   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Age-associated chemokine receptor expression profiles in human peripheral blood monocyte subsets predict cardiovascular disease risk. [PDF]

Front Immunol
Komaravolu RK, Chatterjee N, Kumar S, Allen JL, Durant C, Wu R, Valentin-Guillama G, McSkimming C, Drago F, Taylor AM, Miller YI, Ley K, McNamara CA, Alimadadi A, Hedrick CC.   +14 more
europepmc   +1 more source

Pro- vs. Anti-Inflammatory Features of Monocyte Subsets in Glioma Patients. [PDF]

Int J Mol Sci, 2023
Lehman N, Kowalska W, Zarobkiewicz M, Mazurek M, Mrozowska K, Bojarska-Junak A, Rola R.   +6 more
europepmc   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

The Strontium Ion Reprograms Monocyte Subsets via TRPM2 Channel Regulation to Enhance Osseointegration. [PDF]

Biomater Res
Zhao C, Xu A, Gong J, Xu Y, Sun P, He F.
europepmc   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Distinct osteoclastogenic potential of granulocyte-macrophage colony-stimulating factor-induced monocyte subsets. [PDF]

Bone Rep
Kinoshita S, Omata Y, Sato K.
europepmc   +1 more source