Results 161 to 170 of about 317,992 (233)

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Disease Activity-Dependent Siglec-1 Expression on Monocyte Subsets of Patients with Idiopathic Inflammatory Myopathies. [PDF]

Int J Mol Sci
Baráth S, Nagy-Vincze M, Kun Z, Szinay D, Griger Z, Béldi TG, Szabó K, Száraz-Széles M, Hevessy Z, Griger Z.   +9 more
europepmc   +1 more source

Phenotypic and Functional Heterogeneity of Monocyte Subsets in Chronic Heart Failure Patients. [PDF]

Biology (Basel), 2022
Mongirdienė A, Liobikas J.
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Plasma Leptin Levels, Obstructive Sleep Apnea Syndrome, and Diabetes Are Associated with Obesity-Related Alterations of Peripheral Blood Monocyte Subsets. [PDF]

Immunohorizons, 2023
Meyhöfer S, Steffen A, Plötze-Martin K, Lange C, Marquardt JU, Bruchhage KL, Meyhöfer SM, Pries R.   +7 more
europepmc   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Advanced immunophenotyping of lymphocyte and monocyte subsets in healthy Australian adults using a novel spectral flow cytometry panel. [PDF]

Front Immunol
Davies AR, Kwong K, Yu Z, Diamand KEM, Li FJ, Kannitha L, Ali SA, Amjadipour A, Padarin AM, Devoy M, Vohra H, Miraghazadeh B, Jiang SH, Brüstle A, Cherbuin N, Nolan CJ, Cook MC, Gardiner EE, Read S, McNaughton E, Randall KL.   +20 more
europepmc   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Bioinformatic analysis and experimental verification reveal expansion of monocyte subsets with an interferon signature in systemic lupus erythematosus patients. [PDF]

Arthritis Res Ther
Zhang J, Zhuang W, Li Y, Deng C, Xuan J, Sun Y, He Y.   +6 more
europepmc   +1 more source