Results 61 to 70 of about 5,891 (174)

When Joint Aspiration Fails: Point‐of‐Care Ultrasound for Diagnosing Chronic Gout in Prolonged Monoarthritis

Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.
ABSTRACT Background A 34‐year‐old man presented to our primary care clinic with persistent pain and swelling of the right first metatarsophalangeal joint lasting 3 months. A previous clinic had suspected gout based on hyperuricemia, but urate‐lowering therapy was repeatedly withheld because of ongoing inflammation, resulting in prolonged symptoms ...
Takayuki Yamada
wiley   +1 more source

Response to intradermal injection of monosodium urate crystals in Behçet's syndrome. [PDF]

Annals of the Rheumatic Diseases, 1991
The cutaneous response to intradermal injection of monosodium urate crystals was investigated in 97 patients with Behçet's syndrome in Turkey and 14 in the United Kingdom, and in 82 healthy and 88 diseased controls. Urate crystals produced an increased erythematous response in patients compared with controls in both countries.
N, Cakir, H, Yazici, M A, Chamberlain, C G, Barnes, S, Yurdakul, S, Atasoy, A, Akcasu, A, Iscimen   +7 more
openaire   +3 more sources

A Rare Cause of Knee Pain in Gout Patients: Tophi of Patella

The Turkish Journal of Gastroenterology, 2015
Gout is a monosodium urate crystal deposit disease which generally occurs in middle-aged males and postmenopausal females. It is typically characterized by episodic acute and chronic arthritis, due to deposition of monosodium urate crystals in joints ...
Ayhan AŞKIN, Rahime İNCİ, Özlem AKAN, Seçil DEMİRDAL, Korhan BAYRAM   +4 more
doaj  

Two-stage management of uncommon spontaneous rupture of anterior cruciate ligament in knee gouty arthritis: three case reports

Journal of Cartilage & Joint Preservation
Introduction: Monosodium urate crystal deposition can cause knee gouty arthritis (KGA). However, anterior cruciate ligament (ACL) rupture associated with KGA is rarely reported.
Rangga B.V. Rawung, Andriessanto Lengkong, Stefan Kambey, Leo Rendy, Meilany Durry, Raynald Bagy   +5 more
doaj   +1 more source

Recent Advances in Fluorescent Probes for Imaging Enzyme Activity in NETosis

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Fluorescent probes enable real‐time visualization of neutrophil effector functions. This review summarizes current probe design strategies and emerging tools for imaging key enzymatic activities, with emphasis on mechanisms underlying NETosis, a lytic form of neutrophil extracellular trap (NET) formation. We discuss current limitations, challenges, and
Enebie Ramos Cáceres, Marijn J. Hollander, Kimberly M. Bonger   +2 more
wiley   +1 more source

ENT3: A lysosomal urate transporter regulating urate disposition and macrophage inflammation

iScience
Summary: Urate is the final oxidation product of purine metabolism in humans, and its extracellular accumulation leads to the formation of monosodium urate (MSU) crystals that trigger gout.
Isamu Matake, Tomoya Yasujima, Hirotaka Matsuo, Akiyoshi Nakayama, Yu Toyoda, Tappei Takada, Katsuhisa Inoue, Takahiro Yamashiro, Hiroaki Yuasa   +8 more
doaj   +1 more source

Small intestinal tophus mimicking tumor

Human Pathology: Case Reports, 2014
A 72 year old male with hypertension, diabetes mellitus type 2 and previous gouty arthritis presented with weight loss, nausea, and vomiting. Ultrasound and CT scanning of the abdomen revealed a circumscribed tumor mass of the jejunum, 3.7 cm in diameter.
Pragya Katoch, Sara Trier‐Mørch, Mogens Vyberg   +2 more
doaj   +1 more source

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, Volume 78, Issue 8, Page 1765-1775, August 2026.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Systematic review of the subcutaneous air pouch model using monosodium urate and calcium pyrophosphate and recommendations for studying crystal‐related arthropathies

Animal Models and Experimental Medicine
The subcutaneous air pouch model has been used extensively to study the pathophysiology of inflammatory conditions such as joint diseases and the potential efficacy of pharmacological treatments in vivo.
Wenu Hewage, Josif Vidimce, Ryan G. Shiels, Michael Morgan, Andrew C. Bulmer   +4 more
doaj   +1 more source

The pathogenesis of gout

Journal of Rheumatic Diseases
Gout is the most common inflammatory arthritis in adults, associated with hyperuricemia and the chronic deposition of monosodium urate (MSU) crystals. Hyperuricemia results from increased production of uric acid and decreased excretion by the kidneys and
Eun Young Ahn, Min Wook So
doaj   +1 more source