Results 71 to 80 of about 5,891 (174)
Neutrophil Extracellular Traps and Microcrystals
Journal of Immunology Research, 2017 Neutrophil extracellular traps represent a fascinating mechanism by which PMNs entrap extracellular microbes. The primary purpose of this innate immune mechanism is thought to localize the infection at an early stage.
Balázs Rada
doaj +1 more source
Disseminated Chronic Tophaceous Gout With Multi‐Tissue Involvement
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Gout is a metabolic condition in which hyperuricaemia leads to deposition of monosodium urate (MSU) crystals in synovial and peri‐articular tissues. (1) Acutely, synovial deposition causes a painful inflammatory reaction. Over time, chronic hyperuricaemia can lead to deposition of uric acid crystals in alternate tissues, with granulomatous ...
Yee Leng Loh, Fiona Combe
wiley +1 more source
Factors influencing the crystallization of monosodium urate: a systematic literature review [PDF]
BMC Musculoskeletal Disorders, 2015 Gout is a chronic disease of monosodium urate (MSU) crystal deposition. Although hyperuricaemia is the central risk factor for development of gout, not all people with hyperuricaemia have subclinical MSU crystal deposition or indeed, symptomatic disease.
Chhana, Ashika +2 more
openaire +2 more sources
Nucleotide Metabolism in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao +7 more
wiley +1 more source
Primary Costochondral Gout with Concomitant Streptococcal Anterior Chest Wall Abscess: A Rare Diagnostic Challenge [PDF]
Journal of Clinical and Diagnostic ResearchGout is a metabolic disorder caused by deposition of monosodium urate crystals in joints and soft-tissues. Gout classically affects peripheral joints such as the first metatarsophalangeal joint (podagra).
Naushad Ahamed +3 more
doaj +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT Hyperuricemia, characterized by elevated serum uric acid (SUA) levels, is increasingly recognized as a pathological contributor to renal injury through oxidative stress, inflammation, and apoptosis. Hirudin, a thrombin inhibitor derived from leech saliva, has recently been noted for its anti‐inflammatory properties, yet its role in ...
Yingxue Zhao +8 more
wiley +1 more source
ACR Open Rheumatology, Volume 8, Issue 7, July 2026.Objective Although gout is traditionally conceptualized as an episodic disease characterized by acute flares and symptom‐free intercritical periods, some individuals report persistent joint pain that extends beyond flares. This cross‐sectional analysis aimed to explore factors associated with self‐reported pain patterns (constant vs intermittent) in ...
Sarah Stewart +8 more
wiley +1 more source
, 2020 Abstract Background : Although the symptoms of gouty arthritis could be controlled by clinical methods, it is often impossible to remove tophi from joints that cause acute gouty arthritis. Methods : In study, we injected a suspension of MSU into the knee joint of chicken, and then injected uricase solution into the joint after 4, 8 and 12 hours.
Yongmian Chen +13 more
openaire +1 more source
Dual Energy CT: added value in gouty arthritis
Journal of the Belgian Society of Radiology, 2013 Gouty arthritis is an inflammatory reaction as a result of monosodium urate crystal deposition in synovial fluid and periarticular soft tissue. It is the most common form of inflammatory arthritis with an estimated prevalence of 5 per 1000 in the USA ...
J Spermon, CF Van Dijke
doaj +1 more source
Tendon and Ligament Involvement in Gout With Associated Tendon Rupture
ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Thipsukhon Sathapanasiri +4 more
wiley +1 more source