Results 31 to 40 of about 1,649 (211)

A theoretical structure-affinity relationship study of some cannabinoid derivatives [PDF]

, 2008
Indexación: ScieloA ZINDO/1 quantum-chemical structure-affinity relationship study with the KPG model is presented for the in vitro interaction of a group of classical, indole-derived and aminoalkylindole-derived cannabinoids with CB and CB2 receptors ...
Gómez-Jeria, Juan S., Rivas, Jorge, Soto-Morales, Francisco, Sotomayor, Alejandra   +3 more
core   +2 more sources

Diels-Alder Adducts of Morphinan-6,8-Dienes and Their Transformations. [PDF]

, 2022
6,14-ethenomorphinans are semisynthetic opiate derivatives containing an ethylene bridge between positions 6 and 14 in ring-C of the morphine skeleton that imparts a rigid molecular structure.
Cumming, Paul, Fekete, Anikó, Henriksen, Gjermund, Hosztafi, Sándor, Marton, János, Mikecz, Pál   +5 more
core   +1 more source

Home Manufacture of Drugs: An Online Investigation and a Toxicological Reality Check of Online Discussions on Drug Chemistry [PDF]

, 2017
Emerging trends in market dynamics and the use of new psychoactive substances are both a public health concern and a complex regulatory issue. One novel area of investigation is the availability of homemade opioids, amphetamines and dissociatives, and ...
Caldicott D. G. E., Chenail R. J., Grund J. C., Grund J. P., Grund J. P., Husserl E., Kjellgren A., Nikolaou P., UNODC, UNODC, Van Gaalen S., Zabransky T., Zabransky T.   +12 more
core   +1 more source

Preliminary Pharmacological Evaluation of Enantiomeric Morphinans

ACS Chemical Neuroscience, 2014
A series of levo- and dextromorphinan pairs have been synthesized and evaluated for their affinities to the mu, kappa, and delta opioid receptors, the N-methyl-D-aspartate (NMDA) channel, and sigma 1 and 2 receptors. It was found that levo isomers tended to have higher affinities at the opioid receptors and moderate to high affinities to the NMDA and ...
Anna W, Sromek, Brian A, Provencher, Shayla, Russell, Elena, Chartoff, Brian I, Knapp, Jean M, Bidlack, John L, Neumeyer   +6 more
openaire   +2 more sources

Ethylacetate fraction of Anthocleista vogelii Planch demonstrates antiobesity activities in preclinical models [PDF]

, 2021
Purpose: To assess the anti-obesity effect of liquid chromatography mass spectrometry (LCMS) profiled ethylacetate fraction (EF) of Anthocleista vogelii Planch on pancreatic lipase activity in vitro, and on obesity-related hormones in high-fat diet (HFD)-
Anyanwu, Gabriel O., Ejaz, Syeda A., Iqbal, Jamshed, Khan, Shafi U., Onyeneke, Eusebius C., Qamar, Hafiz Misbah ud Din, Rahman, Nisar-ur, Rauf, Khalid   +7 more
core   +2 more sources

Synthesis of Morphinans through Anodic Aryl‐Aryl Coupling

The Chemical Record, 2021
AbstractThe morphinans are an important class of structurally fascinating and physiologically important natural products as exemplified by the famous opium alkaloids of the morphine family. Although this class of secondary metabolites from the juice of the opium poppy capsule was already used for medicinal purposes thousands of years ago, chemical ...
Nina Vierengel, Leander Geske, Eisuke Sato, Till Opatz   +3 more
openaire   +4 more sources

In silico design of novel probes for the atypical opioid receptor MRGPRX2 [PDF]

, 2017
The primate-exclusive MRGPRX2 G protein-coupled receptor (GPCR) has been suggested to modulate pain and itch. Despite putative peptide and small molecule MRGPRX2 agonists, selective nanomolar potency probes have not yet been reported.
A Scimemi, AS Kirshenbaum, AW Sromek, BA Baldo, BD McNeil, Brian K Shoichet, Bryan L Roth, C O'Connor, C Southern, CC Chambers, CE Rosow, E Rojewska, EC Meng, F Horn, Frank I Carroll, H Lin, H Nagase, H Subramanian, H Yamasaki, HE Wu, HF Staats, Hiroshi Nagase, J Bienenstock, J Carlsson, J Li, J Pei, JA Allen, JA Ballesteros, Jian Jin, Jing Liu, JJ Irwin, JJ Irwin, Joel Karpiak, John D McCorvy, JP Overington, JS Mason, K Kumar, K Paruch, K Tatemoto, KA Sharp, Katherine Lansu, KL White, L Malik, M Jordan, M Kamohara, M Rask-Andersen, M Zajac, MH Wang, MJ Zylka, MM Mysinger, MM Mysinger, MP Jacobson, MP Jacobson, MR Hutchinson, N Akuzawa, N Eswar, N Robas, PM Lembo, PM Sweetnam, Q Yang, R Fredriksson, S Barelier, S Podvin, T Johnson, T Ngo, Tao Che, V Isberg, Wesley K Kroeze, WK Kroeze, X Dong, Xi-Ping Huang, XP Huang, YF Jacquet   +72 more
core   +3 more sources

Life‐Threatening Agranulocytosis Induced by Sinomenine Hydrochloride in Chronic Kidney Disease: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Sinomenine, derived from Sinomenium acutum, is widely used in inflammatory diseases. However, its risk of inducing agranulocytosis is not widely appreciated. We report a life‐threatening case in a 40‐year‐old woman with chronic kidney disease (CKD; baseline estimated glomerular filtration rate [eGFR] as low as 36 mL/min/1.73 m2) who developed ...
Ping Xin, Ruoyan Liu, Yu Zhang, Bin Fu
wiley   +1 more source

Toll-Like Receptor 9-Mediated Inflammation Triggers Alveolar Bone Loss in Experimental Murine Periodontitis [PDF]

, 2015
Chronic periodontitis is a local inflammatory disease induced by a dysbiotic microbiota and leading to destruction of the tooth-supporting structures.
Abe, Toshiharu, Crump, Katie E., Hajishengallis, George, Kim, Paul D., Sahingur, Sinem E., Xia-Juan, Xia   +5 more
core   +2 more sources

Metabolome analyses of two varieties of Anhua dark tea

International Journal of Food Properties
We performed volatile and nonvolatile metabolome analysis of Zhuyeqi (Z) and Baihaozao (B) dark teas during three stages of tea processing: (1) after withering and kneading (S), (2) after pile-fermenting (M), and (3) during drying and second kneading (Z).
Zhen Liu, Peidi Yang, Yang Zhao, Furong Qu, Yang Cheng   +4 more
doaj   +1 more source