Results 31 to 40 of about 68 (63)
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The Chemistry and Pharmacology of Morphinan Alkaloids
1985The chemistry of morphinan drugs is closely related to that of morphine through recognition of its structure by Robinson and Sugasawa (1933) and Schopf and Thierfelder (1939). Real progress, however, was made when Grewe and Mondon (1948) reported a novel detailed synthesis of morphinan, the basic unit of the opium alkaloids.
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Biosynthesis of Morphinan Alkaloids
1985By the turn of the century a large number of alkaloids had been isolated, and investigators began to turn their attention to the ways by which these natural products were constructed in the living plant. Many interesting ideas were proposed during the next decades.
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Search for new natural sources of morphinans
Economic Botany, 1986Codeine, medically the most widely used opiate, is mostly derived from morphine, isolated from opium and poppy straw (Papaver somniferum, opium poppy). Morphine, however, is greatly misused by illegal conversion into its diacetyl-derivative: heroin. The discovery of an efficient alternative medicine or a source for codeine other than opium poppy may ...
Hubert G. Theuns +2 more
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QSAR Study on the Antinociceptive Activity of Some Morphinans
Chemical Biology & Drug Design, 2007Quantitative structure–activity relationship studies were performed to describe and predict the antinociceptive activity of 31 morphinan derivatives reported by the US Drug Evaluation Committee in 2005 and 2006. From these, three data sets were constructed and several models were calculated following the multiple linear regression and Leave‐One‐Out ...
Bahram Hemmateenejad +5 more
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ChemInform Abstract: Synthesis of New Morphinane Derivatives.
ChemInform, 1994AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Elvira E. Shults +4 more
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A morphinane alkaloid from roots of Stephania cepharantha
Phytochemistry, 1992Abstract From the roots of Stephania cepharantha , a new morphinane alkaloid, named cephamorphinanine, was isolated along with seven known alkaloids including one aporphine, two morphinanes, one promorphinane and three bisbenzylisoquinolines. The structure of cephamorphinanine was established from spectral analysis and chemical correlation.
Miao Zhen-Chun +3 more
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ChemInform, 1988
AbstractThe diacid (IV) serves as common intermediate for the synthesis of the diketone (V) and the isoquinoline (IX).
Clive W. Bird, K. Naidoo
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AbstractThe diacid (IV) serves as common intermediate for the synthesis of the diketone (V) and the isoquinoline (IX).
Clive W. Bird, K. Naidoo
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Morphinan alkaloids labeled with tritium: synthesis and applications
Journal of Labelled Compounds and Radiopharmaceuticals, 2013AbstractThis review discusses the synthetic methods employed to tritiate morphinan alkaloids as well as their applications.
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Chiroptical properties of morphinan derivatives [PDF]
Collection of Czechoslovak Chemical Communications, 1975 P. Kerekes +6 more
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