Results 51 to 60 of about 1,646 (203)
Two‐Step Synthesis of Enantiomerically Pure Morphans from (R)‐Carvone
ChemMedChem, Volume 19, Issue 24, December 16, 2024.A two‐step procedure transformed the natural product (R)‐carvone into enantiomerically pure morphans allowing selective modifications at 2‐, 4‐ and 6/7‐position. Whereas affinity towards opioid receptors could not be detected, nanomolar σ1 affinity was found for indolomorphans and quinolinomorphans.
Giuliana Costanzo +5 more
wiley +1 more source
Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach
Medicinal Research Reviews, Volume 44, Issue 6, Page 2545-2599, November 2024.Abstract Opioid receptors belonging to the class A G‐protein coupled receptors (GPCRs) are the targets of choice in the treatment of acute and chronic pain. However, their on‐target side effects such as respiratory depression, tolerance and addiction have led to the advent of the ‘opioid crisis’.
Marie Emilie Hovah, Ulrike Holzgrabe
wiley +1 more source
Lethality of the morphinan isomers levorphanol and dextrorphan [PDF]
British Journal of Pharmacology, 1973 Significantly different ...
R, Dingledine, A, Goldstein
openaire +2 more sources
Acta Anaesthesiologica Scandinavica, Volume 68, Issue 10, Page 1565-1572, November 2024.Abstract Background Over the past 25 years, global opioid consumption has increased. Denmark ranks fifth in opioid use globally, exceeding other Scandinavian countries. Postsurgical pain is a common reason for opioid prescriptions, but opioid use patterns after patient discharge from the hospital are unclear.
Mark Puch Oernskov +7 more
wiley +1 more source
Advanced Science, Volume 11, Issue 19, May 22, 2024.Herein, a chromosome‐level genome assembly of Menispermum dauricum is presented. A novel MdCYP80G10 enzyme is identified to catalyze C2′‐C4a phenol coupling of (S)‐reticuline into sinoacutine, the enantiomer of morphinan compounds, with predictable stereospecificity.
Zhoujie An +20 more
wiley +1 more source
Photo‐affinity and Metabolic Labeling Probes Based on the Opioid Alkaloids
ChemBioChem, Volume 25, Issue 6, March 15, 2024.Leon Duque, Vallavoju, and colleagues report the design and development of photo‐affinity and metabolic labeling probes based on the opioid alkaloids. These chemical probes are used to measure localization and protein interactions in a cellular context by confocal microscopy and chemical proteomics.
Mark Anthony Leon Duque +5 more
wiley +1 more source
Synthesis of Alkaloids and Compounds Containing the 3,4‐Benzomorphan Scaffold
European Journal of Organic Chemistry, Volume 27, Issue 1, January 2, 2024.This review summarizes the biosynthesis and the synthesis of several biologically active natural compounds (i. e., alkaloids) and other related compounds containing the hexahydro‐2,6‐methano‐1‐benzazocine structure (i. e., 3,4‐benzomorphan scaffold). Abstract Several natural products, bearing an embedded hexahydro‐2,6‐methano‐1‐benzazocine framework (3,
Laura G. Rodríguez +2 more
wiley +1 more source
, 2016 Morfin, alkaloid izoliran iz opijumskog maka, široko je korišteni opioidni analgetik složene kemijske strukture i fascinanta sintetska meta organskih kemičara. Sertürnerova izolacija morfina iz opijuma 1804.
Kalebić, Demian
core +1 more source
Trajectories of sentiment in 11,816 psychoactive narratives
Human Psychopharmacology: Clinical and Experimental, Volume 39, Issue 1, January 2024.Abstract Objective Can machine learning (ML) enable data‐driven discovery of how changes in sentiment correlate with different psychoactive experiences? We investigate by training models directly on text testimonials from a diverse 52‐drug pharmacopeia. Methods Using large language models (i.e.
Sam Freesun Friedman, Galen Ballentine
wiley +1 more source