Results 51 to 60 of about 1,649 (211)

Development of the Japanese Anticholinergic Risk Scale: English translation of the Japanese article

Geriatrics &Gerontology International, Volume 25, Issue 1, Page 5-13, January 2025.
Background Anticholinergic burden, reflecting the cumulative impact of medications with anticholinergic properties, significantly predicts adverse drug reactions and geriatric syndromes in older adults. Although anticholinergic risk scales (ARS) have been developed and validated in various countries, none have been tailored specifically for Japan.
Fumihiro Mizokami, Tomohiro Mizuno, Rena Taguchi, Izumi Nasu, Sayaka Arai, Keiichiro Higashi, Ayaka Matsumoto, Miwako Kamei, Taro Kojima, Takayoshi Sakai, Yuuka Shibata, Yasushi Takeya, Masaki Mogi, Shizuo Yamada, Masahiro Akishita, Japanese Society of Geriatric Pharmacy Working Group on Japanese Anticholinergic Risk Scale   +15 more
wiley   +1 more source

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e Mediates Aglycemic Neuronal Cell Death [PDF]

, 2015
The astrocyte cystine/glutamate antiporter (system xc−) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred.
He, Yan, Hewett, James A., Hewett, Sandra J., Jackman, Nicole A., Lobner, Doug, Thorn, Trista L.   +5 more
core   +1 more source

Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism [PDF]

, 2014
Oxidative enzymes catalyze many different reactions in plant metabolism. Among this suite of enzymes are the 2-oxoglutarate/Fe(II)-dependent dioxygenases (2-ODDs). Cytochromes P450 (CYPs) as often considered the most versatile oxidative enzymes in nature,
Peter J. Facchini, Scott C. Farrow
core   +2 more sources

Phytochemical Profile and Assessment of In Vivo Anti‐Inflammatory Efficacy of Ficus sycomorus L. (Moraceae) Extracts in Mice

Scientifica, Volume 2025, Issue 1, 2025.
Inflammation helps the immune system identify and eliminate disease‐causing and foreign stimuli and initiate the healing process. Nonsteroidal anti‐inflammatory drugs have been often used in treating inflammation. Synthetic drugs have been associated with severe effects, necessitating the need for alternative medicinal agents.
Stephen Maina Gitahi, Eunice Wothaya Muthee, Mathew Piero Ngugi, Alex Kingori Machocho, Simone Carradori   +4 more
wiley   +1 more source

Two‐Step Synthesis of Enantiomerically Pure Morphans from (R)‐Carvone

ChemMedChem, Volume 19, Issue 24, December 16, 2024.
A two‐step procedure transformed the natural product (R)‐carvone into enantiomerically pure morphans allowing selective modifications at 2‐, 4‐ and 6/7‐position. Whereas affinity towards opioid receptors could not be detected, nanomolar σ1 affinity was found for indolomorphans and quinolinomorphans.
Giuliana Costanzo, Giuseppe Cosentino, Lorella Pasquinucci, Emanuele Amata, Dirk Schepmann, Bernhard Wünsch   +5 more
wiley   +1 more source

Bivalent and bitopic ligands of the opioid receptors: The prospects of a dual approach

Medicinal Research Reviews, Volume 44, Issue 6, Page 2545-2599, November 2024.
Abstract Opioid receptors belonging to the class A G‐protein coupled receptors (GPCRs) are the targets of choice in the treatment of acute and chronic pain. However, their on‐target side effects such as respiratory depression, tolerance and addiction have led to the advent of the ‘opioid crisis’.
Marie Emilie Hovah, Ulrike Holzgrabe
wiley   +1 more source

Lethality of the morphinan isomers levorphanol and dextrorphan [PDF]

British Journal of Pharmacology, 1973
Significantly different ...
R, Dingledine, A, Goldstein
openaire   +2 more sources

Opioid use after surgical treatment in the Danish population—Protocol for a register‐based cohort study

Acta Anaesthesiologica Scandinavica, Volume 68, Issue 10, Page 1565-1572, November 2024.
Abstract Background Over the past 25 years, global opioid consumption has increased. Denmark ranks fifth in opioid use globally, exceeding other Scandinavian countries. Postsurgical pain is a common reason for opioid prescriptions, but opioid use patterns after patient discharge from the hospital are unclear.
Mark Puch Oernskov, Geana Paula Kurita, Suzanne Forsyth Herling, Per Sjøgren, Svetlana Ondrasova Skurtveit, Ingvild Odsbu, Ola Ekholm, Kim Wildgaard   +7 more
wiley   +1 more source

Lineage‐Specific CYP80 Expansion and Benzylisoquinoline Alkaloid Diversity in Early‐Diverging Eudicots

Advanced Science, Volume 11, Issue 19, May 22, 2024.
Herein, a chromosome‐level genome assembly of Menispermum dauricum is presented. A novel MdCYP80G10 enzyme is identified to catalyze C2′‐C4a phenol coupling of (S)‐reticuline into sinoacutine, the enantiomer of morphinan compounds, with predictable stereospecificity.
Zhoujie An, Ranran Gao, Shanshan Chen, Ya Tian, Qi Li, Lixia Tian, Wanran Zhang, Lingzhe Kong, Baojiang Zheng, Lijun Hao, Tianyi Xin, Hui Yao, Yu Wang, Wei Song, Xin Hua, Chengwei Liu, Jingyuan Song, Huahao Fan, Wei Sun, Shilin Chen, Zhichao Xu   +20 more
wiley   +1 more source

Photo‐affinity and Metabolic Labeling Probes Based on the Opioid Alkaloids

ChemBioChem, Volume 25, Issue 6, March 15, 2024.
Leon Duque, Vallavoju, and colleagues report the design and development of photo‐affinity and metabolic labeling probes based on the opioid alkaloids. These chemical probes are used to measure localization and protein interactions in a cellular context by confocal microscopy and chemical proteomics.
Mark Anthony Leon Duque, Nandini Vallavoju, Tiffany Zhang, Robert Yvon, Ying‐Xian Pan, Christina M. Woo   +5 more
wiley   +1 more source