Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase [PDF]
, 2012 Background Both (-) and (+)-naloxone attenuate inflammation-mediated neurodegeneration by inhibition of microglial activation through superoxide reduction in an opioid receptor-independent manner. Multiple lines of evidence have documented a pivotal role
B Liu +53 more
core +3 more sources
A Chemical Overview of Opioid Receptors and Their Agonists [PDF]
, 2019 This work is a brief overview of the three main opioid receptors and some current research of the ways we can change the agonists and how they affect the opioid receptor ...
Kuszak, Noah
core +1 more source
Comment on: Can Intranasal Nalmefene Reduce the Number of Opioid Overdose Deaths?
Clinical Pharmacology in Drug Development, Volume 13, Issue 3, Page 317-318, March 2024.
Phil Skolnick
wiley +1 more source
Studies of alkaloid metabolism in papaver somniferum l [PDF]
, 1992 Six P. somniferum L. cultivars were investigated for quantitative analysis of their alkaloid contents during plant development in the attempt to screen plants with high yields in noscapine and to determine what losses in alkaloid occurred as a result of ...
Pham, Thi Danh Thom
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Studies in isoquinoline chemistry relating to morphine analgesics [PDF]
, 1978 Approaches to the synthesis of partially hydrogenated 8-ketoisoquinolines have been made via 5,6,7,8-tetrahydroisoquinoline and also via attempted Bischler–Napieralski cyclodehydration of a series of 3-oxygenated cyclohexenyl-phenylacetamide derivatives.
Michael J. Powell (2731450)
core
Spatiotemporal oscillations of morphinan alkaloids in opium poppy
Journal of Biosciences, 2018 Here, a comprehensive endeavor is made to simultaneously scrutinize spatiotemporal oscillations of three imperative morphinan alkaloids (i.e. thebaine, codeine, and morphine) alongside dynamic transcriptional patterns of TYDC, SalAT, COR, T6ODM, and CODM genes in different tissues of Papaver somniferum (i.e.
Mahdi, Rezaei +4 more
openaire +2 more sources
Perifériás és centrális receptorok részvétele opioidok fájdalomcsillapító hatásában és mellékhatás spektrumában.Korai drog expozició (perinatális és adoleszcensz) hatásának vizsgálata patkányon = On the role of central and peripheral receptors in the antinociceptive action and side effects of opioids.The influence of early (perinatal and in adolescent age) drug exposition on antinociception [PDF]
, 2011 A fájdalom terápiájának megoldása sürgető és releváns igény. Korábban publikáltunk néhány az agyba limitáltan penetráló morfinant. Jelen munkában kb. 30 új származékot vizsgáltunk.
Fürst, Zsuzsanna +8 more
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Total synthesis and biological activity of "carbamorphine": O-to-CH2 replacement in the E-ring of the morphine core structure. [PDF]
Morphine is a µ-opioid receptor (MOR) agonist and potent analgesic. However, it displays several side effects including respiratory depression and addiction.
Akiyama, Sota +13 more
core +2 more sources
Krokodil: The drug that kills [PDF]
, 2018 Psychotropic substances use and abuse have become a real global problem. Up to now, heroin is still one of the most abused drugs, however its consumption is in sharp decline in favor of Krokodil, also called “the poor’s heroine”. Krokodil originates from
Anna Ferrari, Sheila Leone
core