Results 131 to 140 of about 269,440 (355)

Characterization of a Single Chain Fv Antibody that Reacts with Free Morphine

Antibodies, 2013
An immune phage library derived from mice, hyperimmunized with morphine-conjugated BSA, was used to isolate a single-chain Fv (scFv) clone, M86, with binding activity to morphine-conjugated thyroglobulin (morphine-C-Tg) but not to codeine-, cocaine-, or ...
Kazuhisa Sugimura, Yuta Hamazoe, Koji Arizono, Shinya Kohra, Koichi Tanaka, Mariko Kamegawa, Miho Matsukizono   +6 more
doaj   +1 more source

Effects of HIV and Drugs of Abuse on the Blood-Brain Barrier [PDF]

, 2016
Despite effective systemic therapy, HIV-1 infection within the brain results in neuronal degradation and neurocognitive dysfunction. This neurocognitive dysfunction is worsened in the setting of opiate abuse. The central nervous system (CNS) is protected
Hari, Gopika
core   +1 more source

5‐HT3 receptor antagonists for preventing postoperative nausea and vomiting after gynecological surgery: A systematic review and network meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background Gynecological surgery is generally associated with a high risk of postoperative nausea and vomiting (PONV), for which a combination of antiemetic therapies is advised, but adherence to these protocols is often low. Given the current reality, a preferred 5‐HT3 receptor antagonist for preventing PONV as a result of gynecological ...
Hongxia Xu, Lingyan Rong, Shaohui Yang, Jiankun Xing, Huajun Dong, Huihui Liu, Xiaotao Chen, Lingyan Liu   +7 more
wiley   +1 more source

A crossover study evaluating the sex‐dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects

British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 361-371, January 2023., 2023
Aim We assessed whether total sleep deprivation (TSD) in combination with pain tests yields a reliable method to assess altered pain thresholds, which subsequently may be used to investigate (novel) analgesics in healthy subjects. Methods This was a two‐part randomized crossover study in 24 healthy men and 24 women.
Hemme Hijma, Ingrid Koopmans, Erica Klaassen, Robert Jan Doll, Rob Zuiker, Geert Jan Groeneveld   +5 more
wiley   +1 more source

Effects of Isoniazid on Tolerance and Sensitization to the Rewarding Properties of Morphine: A Conditioned Place Preference Procedure Investigation in Mice

Basic and Clinical Neuroscience, 2020
Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance
Amir Abbas Barzegari, Kamran Shahabi
doaj  

Litigation-Ending Sanctions: Alaska Courts’ Use of Rule 37 [PDF]

, 1985
Pain is a common symptom of a number of conditions including cancer and one of the most frequent reasons for seeking healthcare. Acute and chronic pain result in considerable discomfort with a detrimental impact on the quality of life.
Carroll, Robert
core   +1 more source

Diversity and Ecological Factors Influencing Medicinal Plant Use Among Ethnolinguistic Groups in the Philippines 21世纪菲律宾人类文化语言学族群药用植物多样性及其生态关联研究

Integrative Conservation, EarlyView.
Plant order‐level Sankey plot illustrating plant use of ethnolinguistic groups for key disease types based on organ systems and use. Each node represents the strength of its interaction or usage. ABSTRACT Many human populations rely on natural remedies for health and healing, with traditional medicinal plants playing a vital role in diverse ...
Krizler C. Tanalgo, Yalaira Plang, Kier C. Dela Cruz, Meriam M. Rubio, Bona Abigail Hilario‐Husain, Jeaneth Magelen V. Respicio, Asraf K. Lidasan, Sumaira S. Abdullah, Gerald Vince N. Fabrero, Renee Jane A. Ele, Sedra A. Murray, Yvonne V. Saliling, Radji A. Macatabon, Lothy F. Casim, Jamaica Delos Reyes, Angelo R. Agduma   +15 more
wiley   +1 more source

Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT)

British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 390-400, January 2023., 2023
Aims In the last French study in 2007, the incidence of hospital admissions (HAs) related to adverse drug reactions (ADRs) was 3.6%. The objective was to assess the current ADR‐HA incidence in France and to describe both its characteristics and preventability.
Marie‐Laure Laroche, Sophie Gautier, Elisabeth Polard, Marie‐Blanche Rabier, Laurent Chouchana, Bénédicte Lebrun‐Vignes, Jean‐Luc Faillie, Nadine Petitpain, Laurence Lagarce, Annie‐Pierre Jonville‐Bera, for the IATROSTAT study group   +10 more
wiley   +1 more source

Mitogen-Activated Protein Kinase Signaling Mediates Morphine Induced-Delayed Hyperalgesia

Frontiers in Neuroscience, 2019
The use of morphine, the standard opioid drug, is limited by its undesirable effects, such as tolerance, physical dependence, and hyperalgesia (increased pain sensitivity).
Bárbara Guimaraes de Freitas, Leandro Márcio Pereira, Flávia Vianna Santa-Cecília, Natália Gabriele Hösch, Gisele Picolo, Yara Cury, Vanessa O. Zambelli   +6 more
doaj   +1 more source

Applications of wavelet transform in classification of local field potential recorded from the rat brain in conditioned place preference paradigm [PDF]

arXiv
This study investigates the multi-label classification of Local Field Potential (LFP) data from the hippocampus (HIP) and nucleus accumbens (NAc) in the rat brain, focusing on reward responses using the Conditioned Place Preference (CPP) paradigm. Rats were conditioned with saline, morphine, and food rewards, and LFP recordings were conducted from both
arxiv