The role of hippocampal glial glutamate transporter (GLT‐1) in morphine‐induced behavioral responses
Brain and Behavior, 2021 Opioid abuse modifies synaptic plasticity, which leads to behavioral changes, such as morphine dependence, but the mechanism remains poorly understood.
Negin Saeedi +7 more
doaj +1 more source
Frontiers in Microbiology, 2020 Morphine is one of the most severely abused drugs in the world. Previous research on morphine addiction has focused on the central nervous system (CNS). Studies have shown that a two-way regulation of the brain and gut microbiota (GM), suggesting a link ...
Zhu Chen +8 more
doaj +1 more source
Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. [PDF]
PLoS ONE, 2011 Opiates produce significant and persistent changes in synaptic transmission; knowledge of the proteins involved in these changes may help to understand the molecular mechanisms underlying opiate dependence. Using an integrated quantitative proteomics and
Noura S Abul-Husn +7 more
doaj +1 more source
Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
core +5 more sources
Morphine Addiction and Oxidative Stress: The Potential Effects of Thioredoxin-1
Frontiers in Pharmacology, 2020 Long-term administration of morphine for the management of chronic pain will result in tolerance to its analgesic effect and could even cause drug dependence.
Xian-Si Zeng +3 more
doaj +1 more source
The effect of metformin on morphine analgesic tolerance and dependence in rats
Research in Pharmaceutical Sciences, 2018 Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in ...
Iman Fatemi +3 more
doaj +1 more source
Zagazig Journal of Pharmaceutical Sciences, 2020 Chronic use of opioids as morphine and tramadol to control pain is associated with several side effects and tolerance to their analgesic effect and dependence. Some of the side effects of opioids can be ameliorated by naloxone, however this is associated
Waleed Barakat +3 more
doaj +1 more source
PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury. [PDF]
, 2017 Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions.
Chen, Renxun +5 more
core +1 more source
Eating Pattern of Morphine Dependent Rats
Japanese Journal of Pharmacology, 1979 To analyze the drug ingestion patterns of rats in the course of dependence development while on the drug-admixed food (DAF) method, an automatic food intake measuring apparatus was developed. Rats were put on morphine-admixed food, and the food ingestion patterns were recorded with the apparatus in the course of dependence development, during drug ...
S, Yanaura, T, Suzuki
openaire +5 more sources
On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]
, 2013 The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F +6 more
core +3 more sources