Effects of ATPM-ET, a novel κ agonist with partial μ activity, on physical dependence and behavior sensitization in mice [PDF]
, 2014 Aim: To investigate the effects of ATPM-ET [(−)-3-N-Ethylaminothiazolo [5,4-b]-N-cyclopropylmethylmorphinan hydrochloride] on physical dependence and behavioral sensitization to morphine in mice.
Chen, Jie +11 more
core +1 more source
The Extract of Corydalis yanhusuo Prevents Morphine Tolerance and Dependence
Pharmaceuticals, 2021 The opioid epidemic was triggered by an overprescription of opioid analgesics. In the treatment of chronic pain, repeated opioid administrations are required which ultimately lead to tolerance, physical dependence, and addiction.
Lamees Alhassen +6 more
doaj +1 more source
Dopamine-dependent responses to morphine depend on glucocorticoid receptors [PDF]
Proceedings of the National Academy of Sciences, 1998 Previous work has shown that glucocorticoid hormones facilitate the behavioral and dopaminergic effects of morphine. In this study we examined the possible role in these effects of the two central corticosteroid receptor types: mineralocorticoid receptor (MR), and glucocorticoid receptor (GR).
M, Marinelli +4 more
openaire +2 more sources
Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant. [PDF]
, 2016 Opioid use in pregnancy has increased dramatically over the past decade. Since prenatal opioid use is associated with numerous obstetrical and neonatal complications, this now has become a major public health problem.
Davis, Jonathan M. +2 more
core +2 more sources
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]
, 2019 © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta +9 more
core +5 more sources
Rat brain proteome in morphine dependence
Neurochemistry International, 2006 The aim of this study was to reveal potential markers associated with drug dependence, using the proteomic approach. Gels containing samples derived from morphine-treated and control animals were compared and analyzed. Inspection of protein profiles, following TCA/acetone precipitation and the use of nano-scale liquid chromatography coupled to tandem ...
Bierczyńska-Krzysik, Anna +8 more
openaire +3 more sources
The challenge of perioperative pain management in opioid-tolerant patients [PDF]
, 2017 The increasing number of opioid users among chronic pain patients, and opioid abusers among the general population, makes perioperative pain management challenging for health care professionals.
Bifulco, F +9 more
core +2 more sources
-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide [PDF]
Iranian Journal of Basic Medical Sciences, 2016 Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis ...
Siavash Parvardeh +3 more
doaj
Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika +12 more
core +3 more sources
BMC Neuroscience, 2012 Background Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence.
Wen Di +6 more
doaj +1 more source