Results 221 to 230 of about 10,950 (303)

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

The Effect of Intravenous Parecoxib on Early Ambulation After Elective Lumbar Spinal Surgery: A Propensity Score Matching Analysis. [PDF]

J Clin Med
Ruksouy B, Pipanmekaporn T, Pin-On P, Atthakomol P, Boonsong P.   +4 more
europepmc   +1 more source

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, Volume 13, Issue 2, 9 January 2026.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Pharmacotherapy of Neuropathic Pain. [PDF]

Pharmaceuticals (Basel)
Borghi SM.
europepmc   +1 more source

The structure of the designed 1,2,3-triazole-tethered derivatives of morphine.

Faeze Nourmandipour (21553208), Reihane Emadi (21553211), Peyman Salehi (552031), Mona Kamelan Zargar Zarin (21553214), Mona Khoramjouy (21553217), Amirreza Dowlati Beirami (21553220), Mehrdad Faizi (21553223)   +6 more
openalex   +1 more source

Artificial Super‐Receptor Interface Mimic and Exceed Protein Functionality

Aggregate, Volume 7, Issue 1, January 2026.
Protein‐mimicking artificial super‐receptor was developed from protein‐similar pure organic groups to super‐performed artificial interface, and achieved revolutionary broad‐spectrum specificity for amphetamine drugs mimicking to protein functionality; and super‐performance beyond nature (64,580× sensitivity of human DAT protein).
Wei Xu, Wen Luo, Xiaodong Liu, Zhen Zhu, Zhimin Hou, Mengqin Wu, Zhanlei Han, Jie Wang, Kai Wu, Wenxing Xu, Huan Liu, Bo Wang, Huizi Li, Yanyan Fu, Qingguo He, Zhiqian Guo, Jiangong Cheng   +16 more
wiley   +1 more source

Clinical Approach to Acute Recreational Drug Intoxication in the Emergency Setting: A Practical Guide Based on Swiss Experience. [PDF]

Toxics
Bless P, Blaser D, Castelain T, Pugnale S, Ribordy V, Guechi Y.   +5 more
europepmc   +1 more source

The Effects of Bone‐Remodeling Therapy on Survival, Pain, and Skeletal Related Events in the Setting of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From a Large Global Health Research Network (TriNetX)

Cancer Medicine, Volume 15, Issue 1, January 2026.
In this retrospective population study containing 139,859 patients, subjects receiving RANK‐ligand inhibitors had improved survival and decreased rates of skeletal‐related events relative to the overall cohort of patients with metastatic bone lesions.
Brian H. Im, Kevin K. Zarrabi, Aaron R. Hochberg, Mihir S. Shah, James R. Mark, Joseph K. Izes, Patrick T. Gomella, Costas D. Lallas, Leonard G. Gomella, Adam R. Metwalli   +9 more
wiley   +1 more source

Uncovering New Antimelanoma Strategies: Experimental Insights into Semisynthetic Pentacyclic Triterpenoids. [PDF]

Life (Basel)
Ungureanu Similie D, Bora L, Chiriac SD, Avram Ș, Minda D, Lugiņina J, Kroškins V, Turks M, Magyari-Pavel IZ, Dinu Ș, Dehelean CA, Danciu C.   +11 more
europepmc   +1 more source

The Synthesis of Unnatural Morphine Derivatives as Glial Activation Inhibitors and The Synthesis of Corticosterone-Glucuronide

, 2010
Morin M. Frick
openalex   +1 more source