Results 1 to 10 of about 51,725 (184)

Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 pathway [PDF]

Neural Regeneration Research, 2023
Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine ...
Tong-Tong Lin, Chun-Yi Jiang, Lei Sheng, Li Wan, Wen Fan, Jin-Can Li, Xiao-Di Sun, Chen-Jie Xu, Liang Hu, Xue-Feng Wu, Yuan Han, Wen-Tao Liu, Yin-Bing Pan   +12 more
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Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis [PDF]

Journal of Pharmaceutical Analysis, 2023
Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. Although the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine tolerance ...
Jia-Jia Zhang, Chang-Geng Song, Miao Wang, Gai-Qin Zhang, Bin Wang, Xi Chen, Peng Lin, Yu-Meng Zhu, Zhi-Chuan Sun, Ya-Zhou Wang, Jian-Li Jiang, Ling Li, Xiang-Min Yang, Zhi-Nan Chen   +13 more
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Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice [PDF]

Frontiers in Pharmacology, 2022
Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia.
Liqiong He, Liqiong He, Wei Xu, Chengliang Zhang, Chengliang Zhang, Zhuofeng Ding, Zhuofeng Ding, Qulian Guo, Qulian Guo, Wangyuan Zou, Wangyuan Zou, Jian Wang, Jian Wang   +12 more
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Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential [PDF]

Frontiers in Pharmacology
Morphine has a crucial role in treating both moderate to severe pain and chronic pain. However, prolonged administration of morphine can lead to tolerance of analgesia, resulting in increased doses and poor treatment of pain. Many patients, such as those
Xiangning Zhang, Xiangning Zhang, Tingting Jin, Tingting Jin, Haixia Wang, Haixia Wang, Shuai Han, Shuai Han, Yongxin Liang, Yongxin Liang   +9 more
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The effect of cannabinoid type 2 receptor agonist on morphine tolerance [PDF]

IBRO Neuroscience Reports
Pain highly impacts the quality of life of patients. Morphine is used for pain treatment; however, its side effects, especially morphine tolerance, limit its use in the clinic. The problem of morphine tolerance has plagued health workers and patients for
Di Cui, Yuanyuan Zhang, Mingyue Zhang
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NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance [PDF]

Cell Communication and Signaling
Background The development of morphine tolerance presents a major clinical challenge in the effective management of severe pain. This study aims to explore the mechanisms underlying morphine tolerance from a novel perspective, with the ultimate goal of ...
Qingyan Tian, Haiyue Guo, Mengyao Zhang, Kunmao Jiang, Fan Hu, Yan Xu, Li Wan, Xiaokai Zhou, Yinbing Pan, Wentao Liu, Chun-Yi Jiang   +10 more
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Progress in the study of intestinal microbiota involved in morphine tolerance [PDF]

Heliyon
Morphine is a widely used opioid for treatment of pain. The attendant problems including morphine tolerance and morphine dependence pose a major public health challenge.
Ke Bi, Yi Lei, Deshenyue Kong, Yuansen Li, Xuan Fan, Xiao Luo, Jiqun Yang, Guangqing Wang, Xuejun Li, Yu Xu, Huayou Luo   +10 more
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Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance [PDF]

Frontiers in Pharmacology
IntroductionMorphine is a widely used analgesic, but its prolonged use often leads to tolerance, limiting its therapeutic efficacy. Research implicates the NLRP3 inflammasome and reactive astrocytes in the development of morphine tolerance, with reactive
Zhenyu Yuan, Boxuan Lu, Meiling Zhang, Yinxiao Lu, Zhihui Wang, Wenhao Zhang, Hao Cheng, Zhifang Wu, Qing Ji   +8 more
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Involvement of CXCL12/CXCR4 in CB2 receptor agonist-attenuated morphine tolerance in Walker 256 tumor-bearing rats with cancer pain [PDF]

European Journal of Medical Research
While low-dose cannabinoid 2 (CB2) receptor agonists attenuate morphine tolerance in cancer pain models, chemokine ligand 12 (CXCL12)/chemokine receptor 4 (CXCR4) expression induces morphine tolerance.
Dandan Liu, Mingyue Zhang, Xiaohai Xu, Xuelai Zhong, Chao Ma, Xiaoyu Zheng, Xiaohong Wu, Guonian Wang   +7 more
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Targeting exosomal double-stranded RNA-TLR3 signaling pathway attenuates morphine tolerance and hyperalgesia [PDF]

Cell Reports Medicine
Summary: Long-term morphine use leads to tolerance and hyperalgesia in patients with chronic pain, with neuroinflammation playing a key role, but its underlying mechanisms remain elusive.
Bing Wang, Dong-Sheng Le, Li Liu, Xue-Xue Zhang, Fan Yang, Guo-Rong Lai, Chao Zhang, Mai-Lin Zhao, Yun-Peng Shen, Ping-Sheng Liao, Tong Liu, Ying-Ping Liang   +11 more
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