Results 131 to 140 of about 51,793 (252)
Alcohol, Clinical and Experimental Research, Volume 50, Issue 3, March 2026.Targeting stress‐escalated alcohol drinking could help patients with alcohol use disorder (AUD). We found that reducing the activity of the epigenetic regulatory enzyme G9a (aka euchromatic histone‐lysine N‐methyltransferase 2 or EHMT2) by repeated systemic administration of a G9a inhibitor reduces stress‐escalated ethanol drinking in a mouse model ...
Deltrice Holmes +4 more
wiley +1 more source
Psilocybin and Ibogaine in Cocaine‐Seeking: Extinction Enhancement Without Relapse Prevention
Addiction Biology, Volume 31, Issue 3, March 2026.Using a preclinical model of cocaine self‐administration, we examined the effects of psilocybin and ibogaine on extinction learning and relapse‐like behaviour. Both compounds, administered during the extinction phase, reduced cocaine seeking, indicating facilitation of extinction learning. However, neither treatment prevented cue‐induced reinstatement.
Isis Rita Anzel Koutrouli +16 more
wiley +1 more source
Journal of Pain Research, 2017 Haiqin Li, Rong Tao, Jing Wang, Lingjie Xia Department of Clinical Pain, The People’s Hospital of Henan Province, Zhengzhou, People’s Republic of China Abstract: Several lines of evidence indicate that microRNAs (miRNAs ...
Li HQ, Tao R, Wang J, Xia LJ
doaj
The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal
Addiction Biology, Volume 31, Issue 3, March 2026.Buprenorphine can either precipitate or relieve opioid withdrawal depending on the timing of administration relative to full opioid agonist exposure. The article proposes that buprenorphine promotes mu‐opioid receptor (MOR) externalization and resensitization, creating a temporary signaling gap that explains precipitated withdrawal when full agonists ...
Mehdi Haghdoost +6 more
wiley +1 more source
Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice. [PDF]
J Tradit Chin Med, 2023 Shuai H +7 more
europepmc +1 more source
Drug and Alcohol Review, Volume 45, Issue 3, March 2026.ABSTRACT Introduction Opioid agonist treatment (OAT) is one of the most effective treatments for opioid dependence, but there can be barriers to accessing treatment. This study examined characteristics associated with OAT engagement—never, previous or current—among people with opioid dependence in NSW, Australia, following recent reforms to OAT access.
Thomas Santo Jr +11 more
wiley +1 more source
Basic and Clinical Neuroscience, 2016 Introduction: Morphine is a potent analgesic but its continual use results in analgesic tolerance. Mechanisms of this tolerance remain to be clarified.
Shamseddin Ahmadi +2 more
doaj
Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow +4 more
wiley +1 more source
Nurses' Pain Assessment and Attitudes: A Qualitative Study in a Neurointensive Care Unit
Nursing in Critical Care, Volume 31, Issue 2, March 2026.ABSTRACT Background As analgo‐sedation gains prominence, a significant portion of adult ICU patients—including those in neurointensive care units (neuro‐ICUs)—remain awake and conscious throughout their stay. Despite this, neuro‐ICU patients frequently experience moderate to severe pain, highlighting the critical need for enhanced pain assessment.
Janni Kristina Voldbjerg +2 more
wiley +1 more source
Ingestion of Amniotic Fluid Enhances\ud Opiate Analgesia in Rats [PDF]
, 1986 Placenta ingestion has recently been shown to enhance opiate-mediated analgesia produced by morphine injection, footshock, or vaginal/cervical stimulation.
Abbott, Patricia +2 more
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