Results 191 to 200 of about 51,793 (252)
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Prolactin analgesia: Tolerance and cross-tolerance with morphine
European Journal of Pharmacology, 1985The development of acute tolerance to prolactin-induced analgesia in mice was identified by using the writhing test. This tolerance was antagonised by naltrexone pretreatment indicating a role of an opioid mechanism. Cross-tolerance between morphine and prolactin was observed with regard to analgesia.
S, Ramaswamy, S, Viswanathan, J S, Bapna
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The Journal of Pharmacology and Experimental Therapeutics, 1997
The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems ...
C A, Fairbanks, G L, Wilcox
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The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our experiments examined the modulation of acutely induced tolerance to spinally administered morphine by agonists that affect the N-methyl-D-aspartate receptor and nitric oxide synthase systems ...
C A, Fairbanks, G L, Wilcox
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Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance
Pain, 2005Pain sensitivity reflects a balance between pain facilitatory and inhibitory systems. To characterize the relationships between these systems we examined the interactions between the analgesic effects of morphine and the anti-analgesic effects of the pro-inflammatory cytokine interleukin-1 (IL-1).
Yehuda, Shavit +4 more
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Attenuation of Morphine Analgesic Tolerance by Rosuvastatin in Naïve and Morphine Tolerance Rats
Inflammation, 2014Recent studies suggested that statins have anti-inflammatory effects beyond their lipid-lowering properties. Since inflammation in the central nervous system was highly related to morphine tolerance, we sought to investigate whether statins could affect morphine tolerance by mediating glia-derived proinflammatory cytokines secretion. We have undertaken
Yongle, Li +5 more
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Tolerance to electroacupuncture and its cross tolerance to morphine
Neuropharmacology, 1981Abstract Electroacupuncture (EA) applied to both legs of the rat for 30 min (1session) raised the average tail flick latency to 89% above the control level. Repeated electroacupuncture for 6 sessions, with 30 min between successive sessions, resulted in a gradual decline in the hypoalgesic effect.
J S, Han, S J, Li, J, Tang
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Morphine tolerance and naloxone receptor binding
Life Sciences, 1975Abstract 3H-naloxone specific binding studies have confirmed the induction of receptor expansion after an acute injection of morphine, as reported by Pert et al (3) as well as the lack of expansion in chronically morphinized rats shown by Klee and Streaty (4) using dihydromorphine.
J, Harris, D T, Kazmierowski
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Binding of Morphine in Tolerant Rats
British Journal of Addiction to Alcohol & Other Drugs, 1968SummaryThe proportion of bound morphine: [100 (total‐free morphine): (total morphine)] in the liver and of free morphine in the blood of tolerant rats receiving a lethal dose of morphine by intravenous infusion at 1, 3, 8 and 16 days after withdrawal were studied. The results were compared with those obtained in two groups of non‐tolerant controls. One
A, Penna-Herreros +2 more
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GABA in morphine analgesia and tolerance
Life Sciences, 1985Drugs affecting various steps of GABA transmission exhibit analgesia in a variety of experimental models in animals; this analgesic response generally requires high doses of the drugs and does not appear to be opiate-like since the GABAergic analgesia is naloxone-insensitive and lacks dependence liability.
S P, Sivam, I K, Ho
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Tolerance to Drugs, especially to Morphine
Nature, 1960VARIOUS theories have been put forward to elucidate the development of tolerance to a drug. For example, it has been observed by Zauder1 that “as tolerance develops (in the rat), the amount of morphine appearing in the urine decreases”. This was in accordance with Gross and Thomson's observations on the dog2. Cochin et al.
G, NADEAU, G, SOBOLEWSKI
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THIP analgesia: Cross tolerance with morphine
Life Sciences, 1983THIP (4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridone-3-ol), a direct acting GABA receptor agonist, has been shown to have antinociceptive properties. To determine whether tolerance develops to the analgesic response, mice received multiple injections of THIP for up to 21 days after which analgesia was tested using both tail immersion and hot-plate ...
T, Andree, D A, Kendall, S J, Enna
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