Results 171 to 180 of about 26,218 (217)

Effect of p‐chloroamphetamine on morphine withdrawal syndrome

Drug Development Research, 1991
AbstractAdult male rats were injected four times a day with increasing doses of morphine sulfate until a dose of 405 mg/kg/day was tolerated. After 5 days of maintenance at that dose, withdrawal signs were observed at 24, 48, and 72 hr of withdrawal.
Harbans Lal, Chejerla Reddy
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Suppression of the drug-induced morphine withdrawal syndrome by cyproheptadine

Psychopharmacologia, 1973
In rats treated with gradually increasing amounts of morphine hydrochloride until they tolerated fatal doses, levallorphan precipitated acute body weight loss and elicited a variety of other typical withdrawal symptoms. Cyproheptadine markedly reduced this b.w. loss and abolished the drug-induced withdrawal syndrome.
K, Opitz, I, Reimann
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Chronic morphine administration: Plasma levels and withdrawal syndrome in rats

Pharmacology Biochemistry and Behavior, 1976
Morphine, administered to Sprague-Dawley rats over a period of 65 hr either by the simultaneous implantation of two 75 mg pellets, or by a series of twice daily 20 or 30 mg/kg injections, produced dependence as indicated by the precipitation of the abstinence syndrome with the antagonist, naloxone.
C, Cerletti, S H, Keinath, M M, Reidenbery, M W, Alder   +3 more
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Effects of cholinergic agonists and antagonists on morphine-withdrawal syndrome

Psychopharmacology, 1976
The effects of pilocarpine, atropine and dexetimide were studied on the occurrence and intensity of morphine-withdrawal signs observed after cessation of chronic morphine injections. Pilocarpine was effective in reducing both 'wet-dog' like body shakes and aggression but it increased diarrhea and weight loss.
M D, Hynes, G, Gianutsos, H, Lal
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Effects of calcitonin on morphine tolerance and withdrawal syndrome in morphine physically dependent rats

European Journal of Pharmacology, 1989
We investigated the effect of acute or chronic peripheral administration of [Asu1.7]eel-calcitonin on the development of tolerance to the analgesic effect of morphine and on the naloxone-precipitated withdrawal syndrome in morphine-dependent rats. Neither the analgesic effect of acute morphine nor the development of tolerance to the antinociceptive ...
CLEMENTI G, VALERIO C, PRATO A, CARUSO A, PATTI, Francesco, PATANÈ S, DRAGO, Filippo   +6 more
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Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine

European Journal of Pharmacology, 2005
Previous investigations had shown that inhibitor of serotonin reuptake transporter (SERT) could attenuate morphine withdrawal syndrome in adult animals. In the present study, we determined whether postnatal injection of serotonin reuptake inhibitors, fluoxetine, clomipramine, or citalopram, is able to attenuate the expression of the naloxone ...
Chi-Chen, Wu, Julia Yi-Ru, Chen, Pao-Luh, Tao, Yi-Ann, Chen, Geng-Chang, Yeh   +4 more
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The effects of orally active enkephalinase inhibitors on morphine withdrawal syndrome

NeuroReport, 1992
Considerable evidence has accumulated to suggest that intracerebroventricular administration of enkephalinase inhibitors, which do not penetrate the blood-brain barrier, significantly attenuates opioid withdrawal syndrome. Therefore, the aim of this study was to examine the effect of intraperitoneal (i.p.) administration of orally active enkephalinase ...
M R, Dzoljic, A, Bokszanska, A M, Korenhof, C D, Kaplan, M, Dzoljic, J, Rupreht, F J, Zijlstra, E C, Brinkman, S L, Cappendijk   +8 more
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Changes in benzodiazepine-receptor activity modify morphine withdrawal syndrome in mice

Drug and Alcohol Dependence, 1992
The effects of different benzodiazepine-receptor ligands on morphine withdrawal were studied: a benzodiazepine agonist, flunitrazepam; a benzodiazepine antagonist, flumazenil; a partial inverse benzodiazepine agonist, Ro 15-4513; and a partial benzodiazepine agonist, Ro 16-6028. Benzodiazepine-ligands were administered i.p.
O, Valverde, J A, Micó, R, Maldonado, J, Gibert-Rahola   +3 more
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Suppression of morphine withdrawal syndrome by interleukin-2 and its gene

NeuroReport, 2005
The naloxone-precipitated withdrawal syndrome in mice and rats after intrathecal injection of recombinant human interleukin-2 protein (rIL-2) or its gene was studied. The results showed that rIL-2 could significantly decrease the number of jumps in mice.
Jinfa, Gu, Mingzhong, Yao, Jinhui, Wang, Wenhua, Zhou, Guodong, Yang, Huifeng, Liu, Zilai, Zhang, Xinyuan, Liu   +7 more
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Methylnaloxone suppresses the development of withdrawal syndrome in morphine-dependent rats

Bulletin of Experimental Biology and Medicine, 2007
We studied the effect of peripheral opioid receptor antagonist methylnaloxone on the development of withdrawal syndrome in morphine-dependent rats. Intraperitoneal injections of methylnaloxone iodide in a daily dose of 2 mg/kg over 3 days after morphine withdrawal reduced the severity of withdrawal symptoms.
S K, Sudakov, I V, Rusakova, M M, Trigub, I A, Pomytkin   +3 more
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