Results 181 to 190 of about 26,218 (217)
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Neurosteroids and the naloxone-precipitated withdrawal syndrome in morphine-dependent mice
European Neuropsychopharmacology, 1996The effects of some neurosteroids on behavioral and hormonal markers of the naloxone-precipitated withdrawal syndrome in morphine-dependent mice were examined. 5 alpha-Pregnane-3, 20-dione inhibited dose-dependently the jumping behavior and the number of forepaw tremors, at a dose of 5 mg/kg it attenuated body weight loss; deoxycorticosterone acetate ...
B, Budziszewska +2 more
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Attenuation of morphine tolerance and withdrawal syndrome by coadministration of nalbuphine
Archives of Pharmacal Research, 2006Morphine has been used widely on the treatment of many types of chronic pain. However the development of tolerance to and dependence on morphine by repeat application is a major problem in pain therapy. The purpose of the present study was to investigate whether combined administration of nalbuphine with morphine affects the development of tolerance to
Soyong, Jang +7 more
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Cholecystokinin modulates the aversive component of morphine withdrawal syndrome in rats
Neuroscience Letters, 1998The conditioned place aversion paradigm was used to investigate the role of cholecystokinin in the aversive/dysphoric component of morphine abstinence. Several cholecystokinin ligands were chronically administered during the development of morphine dependence: the CCKA antagonist devazepide, the CCKB antagonists PD-134,308 and L-365,260, and the CCKB ...
O, Valverde, B P, Roques
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Effects of morphine withdrawal syndrome on endo-oligopeptidase (EC 3.4.22.19) activity
European Journal of Pharmacology, 1994Endo-oligopeptidase (EC 3.4.22.19), an enzyme capable of generating enkephalin by single cleavage from enkephalin-containing peptides, was examined in several areas of the central nervous system (CNS) as well as in the immune and endocrine tissues of rats chronically treated with morphine and submitted to naloxone-induced withdrawal.
S H, Paik +6 more
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Modification of precipitated morphine withdrawal syndrome by drugs affecting cholinergic mechanisms
European Journal of Pharmacology, 1973Abstract The effect of drugs which modify cholinergic and other types of neurohumoral transmission (atropine, mecamylamine, physostigmine, propranolol, propranolol-tolazoline combination, diphenhydramine, and imipramine) was tested in 3 doses on the development of the autonomic, non-autonomic and total signs of the morphine withdrawal syndrome ...
K, Jhamandas, M, Sutak, S, Bell
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European Journal of Pharmacology, 1983
The steady-state levels and utilization (alpha-MPT-induced disappearance) of noradrenaline (NA) and dopamine (DA) were measured in distinct mouse brain nuclei after acute morphine challenge, in mice rendered tolerant to morphine, and during the naloxone-precipitated morphine withdrawal syndrome.
G L, Kovács +3 more
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The steady-state levels and utilization (alpha-MPT-induced disappearance) of noradrenaline (NA) and dopamine (DA) were measured in distinct mouse brain nuclei after acute morphine challenge, in mice rendered tolerant to morphine, and during the naloxone-precipitated morphine withdrawal syndrome.
G L, Kovács +3 more
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Neonatal morphine withdrawal syndrome: report of two cases.
Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui, 1991Two siblings born to a morphine-addicted mother with morphine withdrawal syndrome were reported. The first child, a female, presented with irritability, jitteriness and watery diarrhea at three days of age. The second, a male, presented with jitteriness and irritability when twelve hours old.
W C, Ku, K I, Tsou Yau
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Comparative study in mice of flunitrazepam vs. diazepam on morphine withdrawal syndrome
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19881. There is some evidence that benzodiazepine may modify the opioid withdrawal syndrome. We have investigated the effect of two different benzodiazepines, diazepam and flunitrazepam, on the morphine withdrawal syndrome experimentally induced in mice. 2. Opiate dependence has been induced by administration of morphine s.c.
J, Gibert-Rahola +4 more
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Free Radical Biology and Medicine, 2012
There are few efficacious interventions to combat morphine dependence. Thioredoxin-1 (Trx-1) and heat shock protein 70 (Hsp70) are emerging as important modulators of neuronal function. They have been shown to be involved in cellular protective mechanisms against a variety of toxic stressors.
Fu-Cheng, Luo +7 more
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There are few efficacious interventions to combat morphine dependence. Thioredoxin-1 (Trx-1) and heat shock protein 70 (Hsp70) are emerging as important modulators of neuronal function. They have been shown to be involved in cellular protective mechanisms against a variety of toxic stressors.
Fu-Cheng, Luo +7 more
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Life Sciences, 2000
The role of the cannabinoid system in morphine withdrawal was examined through long-term CB1 receptor antagonist administration in morphine pellet implanted rats. SR141716A chronic treatment (5mg/kg i.p. twice a day for four days) did not influence the development of tolerance to the morphine analgesic effect but significantly reduced the intensity of ...
RUBINO, TIZIANA +4 more
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The role of the cannabinoid system in morphine withdrawal was examined through long-term CB1 receptor antagonist administration in morphine pellet implanted rats. SR141716A chronic treatment (5mg/kg i.p. twice a day for four days) did not influence the development of tolerance to the morphine analgesic effect but significantly reduced the intensity of ...
RUBINO, TIZIANA +4 more
openaire +3 more sources