Results 51 to 60 of about 1,336,492 (154)

The Roles of EETs in Neurological Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang, Mengya Li, Banglian Hu, Guoqiang Fei, Honghua Zheng, Xin Wang, Jing Ding   +6 more
wiley   +1 more source

The Role of Medial Prefrontal Cortex and Ventral Tegmental Areas in Withdrawal Syndrome in Morphine Addicted Male Rats

مجله دانشکده پزشکی اصفهان, 2020
Background: One of the problems of addiction treatment is the relapsing of withdrawal syndrome signs in the addicted person. Rewarding brain regions such as medial prefrontal cortex (mPFC) and ventral tegmental area (VTA) are involved in addiction and ...
Asal Keramatian, Hojjatallah Alaei, Akram Eidi, Maryam Radahmadi   +3 more
doaj   +1 more source

Management of Pain in the Intensive Care Unit: A Nordic Survey

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Pain is common in intensive care unit (ICU) patients with up to one‐third experiencing pain at rest and even more during mobilization and clinical procedures. This survey aimed to explore physicians' attitudes and preferences regarding pain management in adult ICU patients in the Nordic countries.
Benedikte Kollerup Madsen, Morten Hylander Møller, Stine Estrup, Lone Musaeus Poulsen, Bodil Steen Rasmussen, Kirstine Sylvester Conradsen, Thomas Lass Klitgaard, Asger Granfeldt, Theis Skovsgaard Itenov, Hans Christian Thorsen Meyer, Signe Tellerup Nielsen, Susanne Andi Iversen, Klaus Tjelle Kristiansen, Morten Heiberg Bestle, Kirsten Møller, Peter Hasse Møller Sørensen, Jeppe Veien Nygaard, Kristian Elgaard, Morten Rune Blichfeldt‐Eckhardt, Ann Christine Waarkjær Olsen, Mette Pedersen, Henrik Westy Hoffmeyer, Peter Martin Hansen, Helle Bundgaard, Marcus Ølgaard Møller, Jarl Sigaard, Kim Zillo Rokamp, Anne Craveiro Brøchner, Christoffer Sølling, Mika Valtonen, Anna‐Maria Kuivalainen, Annukka Vahtera, Stepani Bendel, Martin I. Sigurdsson, Per Martin Bådstøløkken, Fredrik Sjövall, Ole Mathiesen, Lars Peter Kloster Andersen   +37 more
wiley   +1 more source

Research Progress on the Regulatory Mechanisms of Gut Microbiota in Methamphetamine Addiction and Targeted Interventions

Addiction Biology, Volume 31, Issue 9, September 2026.
METH induces gut dysbiosis with increased proinflammatory and decreased beneficial bacteria, impairs mucosal barrier with reduced SCFAs/Occludin and increased permeability, leading to endotoxin leakage. This activates HPA axis, vagus‐CNS pathways, oxidative stress, and gut‐testis axis disturbance, all synergistically causing neurotoxicity, addiction ...
Jihao Yang, Yishuang Dai, Jia Li
wiley   +1 more source

Factors associated with readmission to residential treatment among clients transitioned from detoxification services in Alberta, Canada

The American Journal on Addictions, Volume 35, Issue 5, Page 615-621, September 2026.
Abstract Background and Objectives Readmission to residential treatment increases healthcare costs, strains publicly funded systems, and may not adequately meet clients' needs. This study examined rates and predictors of readmission to residential treatment among clients transitioned from detoxification services.
Abreham Mekonnen
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End‐of‐Life Palliative Care

Journal of Evidence-Based Medicine, Volume 19, Issue 3, September 2026.
ABSTRACT Older patients receiving end‐of‐life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication‐related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end‐of‐life or hospice‐oriented palliative care,
Daiping Li, Yanwu Yang, Yan Zhang, Jirong Yue, Birong Dong, Meiling Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University   +7 more
wiley   +1 more source

Factors Associated With Postsurgical Pain in Children and Adolescents With Cognitive Dysfunction

Journal of Clinical Nursing, Volume 35, Issue 9, Page 3794-3804, September 2026.
ABSTRACT Aim To describe the characteristics of paediatric postoperative patients with cognitive dysfunction and assess the prevalence of pain and associated factors. Desing A descriptive observational study. Methods Cross‐sectional study in children and adolescents who had undergone surgery in the previous 72 h with cognitive dysfunction impeding ...
Débora Sierra‐Núñez, Alejandro Bosch‐Alcaraz, Sandra Parada‐Almansa, Mónica Castro‐Fernández, Susana Asensio‐Sales, Daniel Gracia‐Martínez, Anna Falcó‐Pegueroles, Mª. Ángeles Saz‐Roy, Esperanza Zuriguel‐Pérez   +8 more
wiley   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2834-2852, August 2026.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 324-333, August 2026.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source