Results 91 to 100 of about 28,651 (221)

Downregulation of MLL1 Promotes Intestinal Epithelial Barrier Repair Through Gata4/Bmp4 Activation to Ameliorate Crohn's Disease‐Like Colitis in Mice

Cell Proliferation, EarlyView.
This study elucidates the pivotal regulatory role and mechanism of MLL1 in inflammatory bowel disease. Experimental data demonstrated elevated MLL1 expression levels in TNBS‐induced murine colitis models, with pharmacological inhibition of MLL1 significantly promoting recovery from CD‐like colitis by accelerating intestinal barrier restoration ...
Xue Song, Jing Li, Yue Chen, Bohan Li, Yi Yang, Xiaofan Guan, Xiaofeng Zhang, Lu Tao, Zhijun Geng, Lugen Zuo, Yueyue Wang, Lian Wang, Jianguo Hu   +12 more
wiley   +1 more source

Concentration dependent chromatin states induced by the bicoid morphogen gradient

eLife, 2017
In Drosophila, graded expression of the maternal transcription factor Bicoid (Bcd) provides positional information to activate target genes at different positions along the anterior-posterior axis.
Colleen E Hannon, Shelby A Blythe, Eric F Wieschaus   +2 more
doaj   +1 more source

Scaling of morphogen gradients

Current Opinion in Genetics & Development, 2011
Individuals of the same or closely related species can vary substantially in size. Still, the proportions within and between tissues are precisely kept. This adaptation of pattern with size termed scaling, is receiving a growing attention. We review experimental evidence for scaling, and describe theoretical models for mechanisms that scale morphogen ...
Ben-Zvi D, Shilo BZ, Barkai N.
openaire   +2 more sources

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

eLife, 2019
During embryonic development, diffusible signaling molecules called morphogens are thought to determine cell fates in a concentration-dependent way.
Idse Heemskerk, Kari Burt, Matthew Miller, Sapna Chhabra, M Cecilia Guerra, Lizhong Liu, Aryeh Warmflash   +6 more
doaj   +1 more source

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Morphogen Gradients, in Theory [PDF]

Developmental Cell, 2002
The idea that morphogen gradients are established by a process of repeated cycles of exocytosis and endocytosis-so-called planar transcytosis-has been gaining acceptance. This is now challenged by a theoretical approach that experimental biologists should not dismiss; diffusive mechanisms of gradient formation may be correct after all.
openaire   +3 more sources

Built different: ER cisternae formed by the Arabidopsis Lunapark proteins differ in ultrastructure and affect ER–Golgi transport

New Phytologist, EarlyView.
The endoplasmic reticulum (ER) is a key structure in plant cells that helps produce and transport proteins. We discovered that different Lunapark proteins shape ER structures in distinct ways, affecting protein movement and secretion. Understanding how ER structure influences function can help improve plant‐based production of valuable compounds, such ...
Charlotte Pain, Tatiana Spatola Rossi, Nadine Field, Carmen Mata, Alessia Candeo, Muhammad W. Ali, Flavia Moreira‐Leite, Stanley W. Botchway, Federica Brandizzi, Verena Kriechbaumer   +9 more
wiley   +1 more source