Results 111 to 120 of about 28,651 (221)

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Fast-tracking morphogen diffusion [PDF]

Journal of Theoretical Biology, 2006
The readout of morphogen concentrations has been proposed to be an essential mechanism allowing embryos to specify cell identities [Wolpert Trends Genet 12 (1996) 359], but theoretical and experimental results have led to conflicting ideas as to how useful concentration gradients can be established.
openaire   +3 more sources

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Cholesterol-free and cholesterol-bound HedgehogTwo sparring-partners working hand in hand in the Drosophila wing disc?

Fly, 2013
Hedgehog (Hh) is a signaling ligand conserved from flies to humans that is covalently bound to both palmitate and cholesterol moieties. These lipid modifications are crucial for Hh signaling. A recent article reports that in both flies and human-cultured
Antoine Ducuing, Matthieu Querenet
doaj   +1 more source

HDAC3 Regulates Transcriptional Networks Governing Decidualization

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
HDAC3 orchestrates transcriptional programs essential for uterine decidualization. Loss of HDAC3 disrupts cytoskeletal organization, metabolic signaling, and oxidative stress responses, impairing stromal cell differentiation and decidualization. These alterations compromise uterine receptivity and result in failed embryo implantation.
Loan Thi Kim Nguyen, Dinh Nam Tran, Shamsun Nahar, Tae Hoon Kim, Jae‐Wook Jeong, Jung‐Yoon Yoo   +5 more
wiley   +1 more source

Bicoid gradient formation mechanism and dynamics revealed by protein lifetime analysis

Molecular Systems Biology, 2018
Embryogenesis relies on instructions provided by spatially organized signaling molecules known as morphogens. Understanding the principles behind morphogen distribution and how cells interpret locally this information remains a major challenge in ...
Lucia Durrieu, Daniel Kirrmaier, Tatjana Schneidt, Ilia Kats, Sarada Raghavan, Lars Hufnagel, Timothy E Saunders, Michael Knop   +7 more
doaj   +1 more source

Bicoid--morphogen function revisited.

Fly, 2010
Bicoid (Bcd) functions as a morphogen during Drosophila development. Accordingly, bcd mRNA is maternally localized to the anterior pole of the embryo, and Bcd forms an anterior/posterior gradient, which functions in a concentration dependent fashion. Thus, nuclei receiving identical amounts of Bcd should express the same target genes. However, we found
Löhr, U., Chung, H., Beller, M., Jäckle, H.   +3 more
openaire   +3 more sources

Data‐driven modelling of a gene regulatory network for cell fate decisions in the growing limb bud

Molecular Systems Biology, 2015
Parameter optimization coupled with model selection is a convenient approach to infer gene regulatory networks from experimental gene expression data, but so far it has been limited to single cells or static tissues where growth is not significant. Here,
Manu Uzkudun, Luciano Marcon, James Sharpe   +2 more
doaj   +1 more source

Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

eLife
Dpp/BMP acts as a morphogen to provide positional information in the Drosophila wing disc. Key cell-surface molecules to control Dpp morphogen gradient formation and signaling are heparan sulfate proteoglycans (HSPGs).
Niklas Simon, Abu Safyan, George Pyrowolakis, Shinya Matsuda   +3 more
doaj   +1 more source

Morphogenic Growth 3D Printing

Advanced Materials
AbstractInspired by nature's morphogenesis, a new 3D printing process –growth printing (GP)– takes advantage of a self‐propagating curing front to produce 3D polymeric parts following a growth‐like development plan. The propagation of the curing front is driven by the exothermic polymerization of dicyclopentadiene (DCPD), which transforms the liquid ...
Yun Seong Kim, Minjiang Zhu, Mohammad Tanver Hossain, Derrick Sanders, Rohan Shah, Yuan Gao, Jeffrey S. Moore, Nancy R. Sottos, Randy H. Ewoldt, Philippe H. Geubelle, Sameh H. Tawfick   +10 more
openaire   +2 more sources