Results 121 to 130 of about 33,949 (297)

Mortality neural forecasting

, 2021
Predicting mortality is a major challenge for both demographers and actuaries. The latter need to anticipate various future mortality scenarios with the greatest possible accuracy, as in the case of annuities pricing and longevity risk assessments. However, the current wide range of stochastic mortality models highlights some deficiencies in predicting
openaire   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Forecasting mortality [PDF]

Scandinavian Actuarial Journal, 1932
openaire   +2 more sources

Forecasting life expectancy in São Paulo City, Brazil, amidst the COVID-19 pandemic

Population Health Metrics
Background The COVID-19 pandemic has significantly increased mortality rates, disrupting historical trends and making it challenging to forecast future life expectancy levels. São Paulo, the first city in Brazil to report a COVID-19 case and death, saw a
Maria L. Miranda, Cassio M. Turra, Ugofilippo Basellini   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Examining the oldest-old mortality in the U.S. A forecast reconciliation approach

, 2020
Understanding the heterogeneity in regional-level mortality experience is of fundamental importance. This paper analyzes the state-level mortality rates for 50 U.S.
Li, H
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Using Google Trends Data to forecast homicide mortality: the case of Mexico

Población y Salud en Mesoamérica
Introduction: In Mexico a major public safety concern is how to predict and reduce homicides to implement effective mitigation policies. Methodology: This study aims to compare traditional forecasting models —ARIMA and Vector Autoregressive (VAR)—with ...
Eduardo Vazquez, Eliud Silva
doaj   +1 more source

Using an Improved ARIMA Algorithm to Forecast the Cancer Mortality in Taiwan for the Next Five Years

, 2020
[[abstract]]The first cause of death in the elderly is also cancer, and unfortunately, the percentage of such death in people over 65 years old is increasing with days.
莊政宏;Chuang, Cheng-Hung;呂威甫;Lu, Wei-Fu;陳瑞奇;Chen, Jui-Chi
core