Results 61 to 70 of about 114,749 (302)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Credible Regression Approaches to Forecast Mortality for Populations with Limited Data
Risks, 2019 In this paper, we propose a credible regression approach with random coefficients to model and forecast the mortality dynamics of a given population with limited data.
Apostolos Bozikas, Georgios Pitselis
doaj +1 more source
Design of 1-year mortality forecast at hospital admission: A machine learning approach
Health Informatics Journal, 2021 Palliative care is referred to a set of programs for patients that suffer life-limiting illnesses. These programs aim to maximize the quality of life (QoL) for the last stage of life.
Vicent Blanes-Selva +5 more
doaj +1 more source
Simulation of population’s reproductive behaviour patterns within an agent-oriented regional model [PDF]
, 2015 The study focuses on the research on how the unevenness of demographic transition affects the social and demographic characteristics and their dynamics of a region’s population. The research was conducted by means of computerized experiments (simulations)
Bakhtizin, A. R. +2 more
core +2 more sources
A NEURAL-NETWORK ANALYZER FOR MORTALITY FORECAST [PDF]
ASTIN Bulletin, 2018 AbstractThis article proposes a neural-network approach to predict and simulate human mortality rates. This semi-parametric model is capable to detect and duplicate non-linearities observed in the evolution of log-forces of mortality. The method proceeds in two steps.
openaire +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A comparative study of parametric mortality projection models [PDF]
, 2010 The relative merits of different parametric models for making life expectancy and annuity value predictions at both pensioner and adult ages are investigated. This study builds on current published research and considers recent model enhancements and the
Butt, Z., Haberman, S.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Lee Carter mortality forecasting: application to the Italian population [PDF]
, 2005 In this paper we investigate the feasibility of using the Lee-Carter methodology to construct mortality forecasts for the Italian population. We fit the model to the matrix of Italian death rates for each gender from 1950 to 2000. A time-varying index of
Haberman, S., Russolillo, M.
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source