Results 81 to 90 of about 33,949 (297)
Point and interval forecasts of mortality rates and life expectancy: A comparison of ten principal component methods [PDF]
Using the age- and sex-specific data of 14 developed countries, we compare the point and interval forecast accuracy and bias of ten principal component methods for forecasting mortality rates and life expectancy.
Heather Booth +2 more
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Stochastic population forecasts using functional data models for mortality, fertility and migration [PDF]
Age-sex-specific population forecasts are derived through stochastic population renewal using forecasts of mortality, fertility and net migration. Functional data models with time series coefficients are used to model age-specific mortality and fertility
Heather Booth, Rob J Hyndman
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020 Background. The basis of organizational technologies that ensure the stabilization of mortality is highly relevant. Their development in the Brest region was based on a retrospective analysis of the medical and demographic situation for the period 2006 ...
Pabivantsava N. F.
doaj +1 more source
Stochastic forecast of the population of Poland, 2005-2050 [PDF]
Forecasting the population of Poland is very challenging. Firstly, the country has been undergoing rapid demographic changes. In the 1990s, they were influenced by the political, economic, and social consequences of the collapse of the communist regime ...
Beata Nowok, Anna Matysiak
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Stochastic Mortality, Macroeconomic Risks, and Life Insurer Solvency [PDF]
Motivated by a recent demographic study establishing a link between macroeconomic fluctuations and the mortality index kt in the Lee-Carter model, we assess the impact of macroeconomic fluctuations on the solvency of a life insurance company. Liabilities
Helmut Gründl +2 more
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
International COVID-19 mortality forecast visualization: covidcompare.io. [PDF]
JAMIA Open, 2021 Akre S, Liu PY, Friedman JR, Bui AAT.
europepmc +1 more source