Results 71 to 80 of about 114,749 (302)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Demographic Research, 2011 Using the age- and sex-specific data of 14 developed countries, we compare the point and interval forecast accuracy and bias of ten principal component methods for forecasting mortality rates and life expectancy.
Han Lin Shang +2 more
doaj
Model confidence sets and forecast combination: an application to age-specific mortality
Genus, 2018 Background Model averaging combines forecasts obtained from a range of models, and it often produces more accurate forecasts than a forecast from a single model.
Han Lin Shang, Steven Haberman
doaj +1 more source
Death Rate as a Demo-economic Factor of the Country's Labour Potential Reduction [PDF]
, 2016 The article deals with the impact of mortality rate on the reduction of labour potential. The authors determine the index of years of potential life lost, analyze the primary causes of deaths as well as provide some prognostic estimates concerning the ...
Kobelia, Z. (Zoryana) +2 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Myth of Methuselah and the Uncertainty of Death: The Mortality Fan Charts
Risks, 2016 This paper uses mortality fan charts to illustrate prospective future male mortality. These fan charts show both the most likely path of male mortality and the bands of uncertainty surrounding that path.
Kevin Dowd +2 more
doaj +1 more source
llc: a collection of R functions for fitting a class of Lee-Carter mortality models using iterative fitting algorithms [PDF]
, 2009 We implement a specialised iterative regression methodology in R for the analysis of age-period mortality data based on a class of generalised Lee-Carter (LC) type modelling structures.
Butt, Z., Haberman, S.
core
Multivariate functional time series forecasting: Application to age-specific mortality rates [PDF]
, 2017 This study considers the forecasting of mortality rates in multiple populations. We propose a model that combines mortality forecasting and functional data analysis (FDA).
Gao, Yuan, Shang, Han Lin
core +1 more source
Forecasting and simulating mortality tables
Mathematical and Computer Modelling, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Arató, Miklós +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source