Results 91 to 100 of about 33,949 (297)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

"ANALYSIS OF VITAL STATISTICS AND POPULATION FORECAST IN IRAN" [PDF]

Iranian Journal of Public Health, 1971
This investigation, with the help of present statistics and demographic techniques, deals with the status and quality of bio-incidence, as the basis for recognition of the national population.
M Sotudeh Zand, H Khazaneh   +1 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mortality modelling with arrival of additional year of mortality data: Calibration and forecasting [PDF]

Demographic Research
BACKGROUND: For commonly used mortality models, the existing estimates change with the recalibration of new data. This issue is also known as the lack of the new-data-invariant property.
Kenny Kam Kuen Mok, Chong It Tan, Jinhui Zhang, Yanlin Shi   +3 more
doaj   +1 more source

Forecasting age-specific breast cancer mortality using functional data models [PDF]

Accurate estimates of future age-specific incidence and mortality are critical for allocation of resources to breast cancer control programs and evaluation of screening programs.
Rob J. Hyndman, Dorota M. Gertig, Bircan Erbas   +2 more
core  

Additional file 2 of Model confidence sets and forecast combination: an application to age-specific mortality

, 2018
Detailed point and interval forecast results. While Table 6 presents a summary of the point and interval forecast accuracies, we present the detailed forecast results for ten years in the forecasting period.
Steven Haberman (6001712), Han Lin Shang (6001709)   +1 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Aging of a giant: a stochastic population forecast for China, 2001-2050 [PDF]

This paper presents a stochastic population forecast for China with a special emphasis on population aging. Stochastic forecasting methods have the advantage of producing a projection of the future population including a probabilistic prediction interval.
Cornelia Kraus, Qiang Li, Mieke Reuser, Juha Alho   +3 more
core  

Forecasting mortality using Google trend

CoRR, 2019
9 pages, 3 figures, 2 ...
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source