Results 71 to 80 of about 1,000,669 (300)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

MHC motif viewer [PDF]

open access: yesImmunogenetics, 2008
In vertebrates, the major histocompatibility complex (MHC) presents peptides to the immune system. In humans, MHCs are called human leukocyte antigens (HLAs), and some of the loci encoding them are the most polymorphic in the human genome. Different MHC molecules present different subsets of peptides, and knowledge of their binding specificities is ...
Nicolas, Rapin   +3 more
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

“Floral Ornament of Reality”: Flowers in Worldview of E. T. A. Hoffmann and N. A. Polevoy

open access: yesНаучный диалог
The relevance of this study is grounded in the scholarly significance of the issue of Russian-German literary connections as a crucial factor in intercultural interaction.
N. M. Ilchenko, E. G. Chernysheva
doaj   +1 more source

Evolutionary Analyses Reveal Diverged Patterns of SQUAMOSA Promoter Binding Protein-Like (SPL) Gene Family in Oryza Genus

open access: yesFrontiers in Plant Science, 2019
The SPL (SQUAMOSA promoter binding protein-like) gene family is one of the plant-specific transcription factor families and controls a considerable number of biological functions, including floral development, phytohormone signaling, and toxin resistance.
Hua Zhong   +6 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Bir Taşra Camii Olarak Kozluca Camii’nin Kalem İşi Süslemeler Bağlamında Değerlendirmesi

open access: yesİlahiyat Akademi
Gaziantep’in Şahinbey ilçesinde yer alan Kozluca Camii, Osmanlı sanatında, özellikle de süsleme alanında batılı etkilerin Anadolu’daki taşra camilerine nasıl yansıdığını göstermesi açısından büyük önem taşımaktadır.
Fevziye Eker, Furkan Köksöken
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Kirkitli Dokuma Örnekleri İle Selçuklu Dönemi Mimari Yapılarında Kullanılan Ortak Motifler Üzerine Bir İnceleme ‘‘Aksaray Sultanhanı, Ağzıkarahan ve Alayhan Hanları’’

open access: yesSanat ve İkonografi Dergisi
Türklerin yerleşik hayata geçmesi ile birlikte barınma yerlerini inşasında ilk olarak toprak kullanmışlar ve daha sonra Selçuklular dönemi ile tuğla ve taş kullanmaya başlamışlardır.
Ahmet Melih Çilingir   +1 more
doaj   +1 more source

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